(Q35790287)

English

Phenotypic Heterogeneity in Patients with Homozygous Prothrombin 20210AA Genotype. A paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology

scientific article published on September 2006

In more languages

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1 reference

Europe PubMed Central

Phenotypic Heterogeneity in Patients with Homozygous Prothrombin 20210AA Genotype. A paper from the 2005 William Beaumont Hospital Symposium on Molecular Pathology (English)

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

1 reference

based on heuristic

inferred from title

phenotypic heterogeneity

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

David Bosler

1

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Joan Mattson

2

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Domnita Crisan

3

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 September 2006

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

The Journal of Molecular Diagnostics

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

8

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

4

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

420-425

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

Genetic testing for thrombophilia mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

A review of the clinical and diagnostic utility of laboratory tests for the detection of congenital thrombophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Laboratory detection of inherited thrombophilia: a historical perspective

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Prothrombin 20210A mutation: a mild risk factor for venous thromboembolism but not for arterial thrombotic disease and pregnancy-related complications in a family study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

G20210A is a functional mutation in the prothrombin gene; effect on protein levels and 3'-end formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Clinical and laboratory management of the prothrombin G20210A mutation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Recurrent pulmonary embolism in a 13-year-old male homozygous for the prothrombin G20210A mutation combined with protein S deficiency and increased lipoprotein (a).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Review and management of patients with the prothrombin G20210A polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Low incidence of venous thrombosis in homozygous patients with NT 20210 G to a prothrombin polymorphism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Interaction between the G20210A mutation of the prothrombin gene and oral contraceptive use in deep vein thrombosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

A single genetic origin for the common prothrombotic G20210A polymorphism in the prothrombin gene.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Mutation in blood coagulation factor V associated with resistance to activated protein C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Nucleotide sequence of the gene for human prothrombin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

12 July 2018

Diagnostic issues in thrombophilia: a laboratory scientist's view

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Concomitant heterozygous factor V Leiden mutation and homozygous prothrombin gene variant (G20210A) in patient with cerebral venous thrombosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Prevalence of the prothrombin 20210 G-to-A variant in blacks: infants, patients with venous thrombosis, patients with myocardial infarction, and control subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Increased risk for venous thrombosis in carriers of the prothrombin G-->A20210 gene variant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Prothrombin G20210A mutant genotype is a risk factor for cerebrovascular ischemic disease in young patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

The prothrombin 20210 A allele is frequently coinherited in young carriers of the factor V Arg 506 to Gln mutation with venous thrombophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

25 September 2018

Increased efficiency of mRNA 3′ end formation: a new genetic mechanism contributing to hereditary thrombophilia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

15 November 2018

Homozygous Prothrombin Gene Mutationand Ischemic Cerebrovascular Disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1867627

15 November 2018

Eclampsia in a woman homozygous for the prothrombin G20210A mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prospective registry of 5,451 patients with ultrasound-confirmed deep vein thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to activated protein C caused by the factor VR506Q mutation is a common risk factor for venous thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Leiden Thrombophilia Study (LETS)

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Deep vein thrombosis and pulmonary embolism in the general population. 'The Study of Men Born in 1913'

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two additional homozygous patients for the 20210 prothrombin polymorphism with no venous thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mixed retinal thrombosis in a patient carrying prothrombin gene mutation in a homozygote state

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G20210A homozygosity in antiphospholipid syndrome secondary to systemic lupus erythematosus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Asymptomatic homozygous nt 20210 G to A prothrombin polymorphism in two blood donors belonging to two different kindreds

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A further case of homozygous G20210A prothrombin gene mutation without thromboembolic events

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of prothrombin 20210A allele and methylenetetrahydrofolate reductase C677T genetic mutations in the Chinese population

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A homozygosity state for 20210A prothrombin variant in a young woman as cause of a deep venous thrombosis during pregnancy

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

What clinical significance has the presence of the homozygous G20210A prothrombin gene mutation in a healthy woman?

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The factor V Leiden and prothrombin G20210A mutations in Kirghiz population

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The significance or nonsignificance of the G to A 20210 prothrombin polymorphism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A boy with venous thrombosis, homozygous for factor V Leiden, prothrombin G20210A and MTHFR C667t mutations, but belonging to an asymptomatic family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A patient homozygous for a mutation in the prothrombin gene 3'-untranslated region associated with massive thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A prothrombin gene mutation is significantly associated with venous thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-inheritance of the 20210A allele of the prothrombin gene increases the risk of thrombosis in subjects with familial thrombophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevalence of the prothrombin gene variant (nt20210A) in venous thrombosis and arterial disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The A20210 allele of the prothrombin gene is frequently associated with the factor V Arg 506 to Gln mutation but not with protein S deficiency in thrombophilic families

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical studies and thrombin generation in patients homozygous or heterozygous for the G20210A mutation in the prothrombin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of the MTHFRC677T variant on risk of venous thromboembolism: interaction with factor V Leiden and prothrombin (F2G20210A) mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A three-generation family presenting five cases of homozygosity for the 20210 G to A prothrombin variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Additional genetic risk factors for venous thromboembolism in carriers of the factor V Leiden mutation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A patient homozygous for mutation 20210A in the prothrombin gene with venous thrombosis and transient ischemic attacks of thrombotic origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous G20210A transition in the prothrombin gene associated with severe venous thrombotic disease: two cases in a French family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous G20210A prothrombin gene mutation without thromboembolic events: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prothrombin antigen levels in symptomatic and asymptomatic carriers of the 20210A prothrombin variant

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Laboratory evaluation of hypercoagulable states

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial thrombophilia and the prothrombin 20210A mutation: association with increased thrombin generation and unusual thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thrombosis in a patient with combined homozygosity for the factor V Leiden mutation and a mutation in the 3'-untranslated region of the prothrombin gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Venous thromboembolic disease and the prothrombin, methylene tetrahydrofolate reductase and factor V genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical and analytical relevance of the combination of prothrombin 20210A/A and factor V Leiden: results from a large family

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygotes for prothrombin gene 20210 A allele in a thrombophilic family without clinical manifestations of venous thromboembolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Venous thromboembolism at a young age in a brother and sister with coinheritance of homozygous 20210A/A prothrombin mutation and heterozygous 1691G/A factor V Leiden mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

It is not sure yet whether the nt 20210 G to A prothrombin polymorphism represents a cause of familial venous thrombophilia

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Double-homozygosity for factor V Leiden and the prothrombin gene G20210A variant in a young patient with idiopathic venous thrombosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cerebral venous sinus thrombosis in a neonate with homozygous prothrombin G20210A genotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mesenteric venous thrombosis in a 40-year-old man with homozygous factor II G20210A mutation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk of recurrent venous thrombosis in children with combined prothrombotic risk factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Homozygous 20210G/A prothrombin gene mutation associated with bilateral iliac vein thrombosis: a case report

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Familial thrombophilia is an oligogenetic disease: involvement of the prothrombin G20210A, PROC and PROS gene mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16931580

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.2353/JMOLDX.2006.060014

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

10 August 2017

ResearchGate publication ID

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