(Q35794576)

English

Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene

scientific article published on January 2004

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scholarly article

1 reference

Europe PubMed Central

10 August 2017

1 reference

Europe PubMed Central

Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene (English)

1 reference

Europe PubMed Central

10 August 2017

Alzheimer's disease

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author name string

Debomoy K Lahiri

1

1 reference

Europe PubMed Central

10 August 2017

language of work or name

1 reference

based on heuristic

inferred from title

publication date

1 January 2004

1 reference

Europe PubMed Central

10 August 2017

Journal of Molecular Neuroscience

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Europe PubMed Central

10 August 2017

23

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Europe PubMed Central

10 August 2017

225-233

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Europe PubMed Central

10 August 2017

3

1 reference

Europe PubMed Central

10 August 2017

https://scigraph.springernature.com/pub.10.1385/jmn:23:3:225

0 references

Strategies for drug discovery for cognitive aging and Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure and expression of mouse apolipoprotein E gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Statin therapy for Alzheimer's disease: will it work?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional identification of the promoter of the gene encoding the Rhesus monkey β-amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a peroxisome-proliferator-activated-receptor response element in the apolipoprotein E gene control region

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the 5'-flanking region of the beta-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional characterization of the 5'-regulatory region of the murine apolipoprotein gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific regional transcription of apolipoprotein E in human brain neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel sequence determinants in peroxisome proliferator signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evolution of apolipoprotein E: mouse sequence and evidence for an 11-nucleotide ancestral unit

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E alleles as risk factors in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High expression of apolipoprotein E mRNA in the brains with sporadic Alzheimer's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human apolipoprotein E: the Alzheimer's disease connection.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Risk for Alzheimer's disease correlates with transcriptional activity of the APOE gene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of an upstream regulatory sequence and its binding protein in the mouse apolipoprotein E gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E expression by neurons surviving excitotoxic stress

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular cloning of the promoter of the gene encoding the Rhesus monkey beta-amyloid precursor protein: structural characterization and a comparative study with other species.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transcription factor AP-2 regulates human apolipoprotein E gene expression in astrocytoma cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased apolipoprotein E mRNA in the hippocampus in Alzheimer disease and in rats after entorhinal cortex lesioning

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Abeta-induced glial activation, NF-kappaB, and apolipoprotein E.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Promoter activity of the beta-amyloid precursor protein gene is negatively modulated by an upstream regulatory element

1 reference

https://pubmed.ncbi.nlm.nih.gov/15181251

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1385/JMN:23:3:225

1 reference

Europe PubMed Central

10 August 2017

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0 references

1 reference

Europe PubMed Central

10 August 2017

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