(Q35801569)

10 August 2017

1 reference

title

Aging in vertebrates, and the effect of caloric restriction: a mitochondrial free radical production-DNA damage mechanism? (English)

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10 August 2017

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1 reference

Gustavo Barja

1

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10 August 2017

1 May 2004

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10 August 2017

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10 August 2017

79

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10 August 2017

2

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10 August 2017

235-251

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Methods for monitoring oxidative stress, lipid peroxidation and oxidation resistance of lipoproteins.

10 August 2017

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Homogenous repair of singlet oxygen-induced DNA damage in differentially transcribed regions and strands of human mitochondrial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mitochondrial oxygen radical generation and leak: sites of production in states 4 and 3, organ specificity, and relation to aging and longevity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

From life to death--the struggle between chemistry and biology during aging: the Maillard reaction as an amplifier of genomic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mammalian selenium-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Age- and peroxidative stress-related modifications of the cerebral enzymatic activities linked to mitochondria and the glutathione system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Lipid hydroperoxide-mediated DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Free radical-induced double lesions in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Vitamin E and the prevention of atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Free radicals associated with DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

The interplay of glutathione-related processes in antioxidant defense

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Interactions of nitric oxide-derived reactive nitrogen species with peroxidases and lipoxygenases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Effect of Ethoxyquin on the Longevity of C3H Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Invited review: manganese superoxide dismutase in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Urate and ascorbate: their possible roles as antioxidants in determining longevity of mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Measurements of protein carbonyls, ortho- and meta-tyrosine and oxidative phosphorylation complex activity in mitochondria from young and old rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Novel effects of nitric oxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

The reductive hotspot hypothesis: an update

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Glutathione peroxidase levels in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Redox control of the transsulfuration and glutathione biosynthesis pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxidative biochemical markers; clues to understanding aging in long-lived species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Regional distribution of iron, transferrin, ferritin, and oxidatively-modified proteins in young and aged Fischer 344 rat brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron-sulfur cluster N2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxygen poisoning and x-irradiation: a mechanism in common

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Does oxidative damage to DNA increase with age?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Theories of biological aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Effect of dietary 2-mercaptoethanol on the life span, immune system, tumor incidence and lipid peroxidation damage in spleen lymphocytes of aging BC3F1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Sites and mechanisms responsible for the low rate of free radical production of heart mitochondria in the long-lived pigeon

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Localization of the site of oxygen radical generation inside the complex I of heart and nonsynaptic brain mammalian mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mice deficient in cellular glutathione peroxidase develop normally and show no increased sensitivity to hyperoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mut

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

NADPH oxidase: a universal oxygen sensor?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Non-linear accumulation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidized DNA damage, during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Micronutrients and their influence on mutagenicity and malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Caloric restriction attenuates dityrosine cross-linking of cardiac and skeletal muscle proteins in aging mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Protein oxidation and ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Influence of aging and long-term caloric restriction on oxygen radical generation and oxidative DNA damage in rat liver mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxyradicals and DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Can antioxidant vitamins materially reduce oxidative damage in humans?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Age-dependent increases in oxidative damage to DNA, lipids, and proteins in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mouse models of mitochondrial disease, oxidative stress, and senescence.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mitochondrial disease in superoxide dismutase 2 mutant mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Multi-organ characterization of mitochondrial genomic rearrangements in ad libitum and caloric restricted mice show striking somatic mitochondrial DNA rearrangements with age

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Proteolysis, caloric restriction and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Ascorbate function at the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mitochondrial genome mutation in cell death and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Normal oxidative damage to mitochondrial and nuclear DNA is extensive

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Mitochondria, oxidative stress and aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Quantification and significance of protein oxidation in biological samples

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Inflammation-induced changes in the nutritional biomarkers serum retinol and carotenoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Glutathione and its role in cellular functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Low mutational burden of individual acquired mitochondrial DNA mutations in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Endogenous and endobiotic induced reactive oxygen species formation by isolated hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Superoxide anion radical production in different animal species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Relationship between antioxidant defenses and longevity in different mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Hydrogen peroxide production by liver mitochondria in different species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Oxidative damage, mitochondrial oxidant generation and antioxidant defenses during aging and in response to food restriction in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Protein oxidation and aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

Dehydroascorbate reduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

The glutathione peroxidases

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Low mitochondrial free radical production per unit O2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds.

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Relationship between antioxidants, lipid peroxidation and aging

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

The free radical theory of aging matures

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Mitochondrial DNA in aging and degenerative disease

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Study of vitamin E supplements in relation to muscular dystrophy and other diseases in aging rats

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Progress towards the discovery of xanthine oxidase inhibitors.

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Effects of the Antioxidant Butylated Hydroxytoluene (BHT) on Mortality in BALB/c Mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Antioxidants and longevity of mammalian species

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Induction of beta-polymerase mRNA by DNA-damaging agents in Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Aging: a theory based on free radical and radiation chemistry

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Free Radical Theory of Aging: Effect of Free Radical Reaction Inhibitors on the Mortality Rate of Male LAF1 Mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Dietary restriction alone and in combination with oral ethoxyquin/2-mercaptoethylamine in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

8-oxo-deoxyguanosine levels in heart and brain mitochondrial and nuclear DNA of two mammals and three birds in relation to their different rates of aging

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Effect of Antioxidants on Life-Span of C57BL Mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

The effect of simultaneous administration of tocopherol and sunflower oil on the life-span of female mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Mitochondrial DNA 4977 bp deletion and OH8dG levels correlate in the brain of aged subjects but not Alzheimer's disease patients.

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Reactive species mechanisms of cellular hypoxia-reoxygenation injury

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Maximum life span in vertebrates: Relationship with liver antioxidant enzymes, glutathione system, ascorbate, urate, sensitivity to peroxidation, true malondialdehyde, in vivo H2O2, and basal and maximum aerobic capacity

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Simultaneous induction of SOD, glutathione reductase, GSH, and ascorbate in liver and kidney correlates with survival during aging

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Purification and characterization of glutathione-dependent dehydroascorbate reductase from rat liver

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

An attempt at a rational classification of theories of ageing

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Maintenance on L-deprenyl prolongs life in aged male rats

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Presence of a DNA-4236 bp deletion and 8-hydroxy-deoxyguanosine in mouse cardiac mitochondrial DNA during aging

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Effect of the peroxisome proliferator ciprofibrate on lipid peroxidation and 8-hydroxydeoxyguanosine formation in transgenic mice with elevated hepatic catalase activity

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Unique increase of superoxide dismutase level in brains of long living mammals

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Longevity and antioxidant enzymes, non-enzymatic antioxidants and oxidative stress in the vertebrate lung: a comparative study

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Effects of the type of dietary fat at two levels of vitamin E in Wistar male rats during development and aging. I. Life span, serum biochemical parameters and pathological changes

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

[Radiation induced lipid peroxidation: factors which determine the oxidizability of lipids]

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Hydroperoxyl, superoxide and pH gradients in the mitochondrial matrix: a theoretical assessment

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Biochemical correlates of longevity in two closely related rodent species

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Oxidative stress and aging in the Mongolian gerbil (Meriones unguiculatus)

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Protein oxidation and proteolysis during aging and oxidative stress

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH–ubiquinone reductase preparation

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Effect of antioxidants and nutrients on lipid peroxidation fluorescent products and aging parameters in the mouse

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Susceptibility of heterozygous MnSOD gene-knockout mice to oxygen toxicity

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

The rate of mitochondrial mutagenesis is faster in mice than humans

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

Microarray profiling of gene expression in aging and its alteration by caloric restriction in mice

1 reference

https://api.crossref.org/works/10.1017%2FS1464793103006213

7 January 2021

10.1017/S1464793103006213

Identifiers

DOI

1 reference

10 August 2017

1 reference

PubMed ID

15191224