(Q35824530)

English

Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains

scientific article published in December 1994

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Disruption by interferon-alpha of an autocrine interleukin-6 growth loop in IL-6-dependent U266 myeloma cells by homologous and heterologous down-regulation of the IL-6 receptor alpha- and beta-chains (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

author name string

Schwabe M

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Brini AT

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bosco MC

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Rubboli F

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Egawa M

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Zhao J

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Princler GL

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Kung HF

8

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

1 December 1994

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Journal of Clinical Investigation

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

94

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

2317-2325

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

The soluble interleukin-6 receptor is generated by shedding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

The treatment of multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Oncostatin M, leukemia inhibitory factor, and interleukin 6 induce the proliferation of human plasmacytoma cells via the common signal transducer, gp130.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Established immunoglobulin producing myeloma (IgE) and lymphoblastoid (IgG) cell lines from an IgE myeloma patient.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Autocrine growth factors and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

The effect of alpha and gamma-interferon on proliferation and production of IgE and beta 2-microglobulin in the human myeloma cell line U-266 and in an alpha-interferon resistant U-266 subline.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Regulation of interleukin 6 receptor expression in human monocytes and monocyte-derived macrophages. Comparison with the expression in human hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

COOH-terminal-modified interleukin-3 is retained intracellularly and stimulates autocrine growth.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Interleukin 3 and interleukin 6 synergistically promote the proliferation and differentiation of malignant plasma cell precursors in multiple myeloma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Interleukin 6 gene expression in normal and neoplastic B cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Constitutive expression of the interleukin-6 gene in chronic lymphocytic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Response patterns of purified myeloma cells to hematopoietic growth factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Serum levels of interleukin 6, a potent myeloma cell growth factor, as a reflect of disease severity in plasma cell dyscrasias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Phenotypic analysis of human myeloma cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

A functional protein kinase C is required for induction of 2-5A synthetase by recombinant interferon-alpha A in Daudi cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Plasma cell myeloma--new biological insights and advances in therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

IL-2 dependence of the promotion of human B cell differentiation by IL-6 (BSF-2).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Granulocyte-macrophage colony-stimulating factor synergizes with interleukin-6 in supporting the proliferation of human myeloma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Molecular cloning and expression of an IL-6 signal transducer, gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Autocrine growth factors and tumourigenic transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Retinoic acid-induced growth inhibition of a human myeloma cell line via down-regulation of IL-6 receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Interleukin-6 antisense oligonucleotides inhibit the growth of human myeloma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Recombinant interferon- γ inhibits the growth of IL-6-dependent human multiple myeloma cell lines in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Murine anti-interleukin-6 monoclonal antibody therapy for a patient with plasma cell leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Increase in interleukin 6 (IL-6) and IL-6 receptor expression in a human multiple myeloma cell line, U-266, during long-term in vitro culture and the development of a possible autocrine IL-6 loop

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

The role of interferon-alpha in the management of myelomatosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Acquisition of growth autonomy and tumorigenicity by an interleukin 6-dependent human myeloma cell line transfected with interleukin 6 cDNA

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Dynamics of interleukin-6 internalization and degradation in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Differential regulation of interleukin-6 receptor and gp130 gene expression in rat hepatocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

A protein tyrosine kinase in the interferon alpha/beta signaling pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Coated pits, coated vesicles, and receptor-mediated endocytosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

11 July 2018

Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=330060

22 October 2018

Differential regulation of interleukin-6 receptors by interleukin-6 and interferons in multiple myeloma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function analysis of human IL-6. Epitope mapping of neutralizing monoclonal antibodies with amino- and carboxyl-terminal deletion mutants

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The IL-6 gene but not the IL-6 receptor gene is occasionally rearranged in patients with multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of interferon-alpha and interferon-gamma receptor expression during T-lymphocyte activation and proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity in response to interleukin 6 (IL-6), expression of IL-6 and IL-6 receptor mRNA in a panel of established human multiple myeloma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 is a prognostic factor in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo interleukin 6 gene expression in the tumoral environment in multiple myeloma

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

gamma-Interferon in multiple myeloma: inhibition of interleukin-6 (IL-6)-dependent myeloma cell growth and downregulation of IL-6-receptor expression in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 gene expression in multiple myeloma: a characteristic of immature tumor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of immature and mature myeloma cells in the bone marrow of human myelomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression and ligand-induced modulation of the human interleukin-6 receptor on interleukin-6-responsive cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/7989587

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI117596

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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