(Q35826404)

10 August 2017

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title

Use of CpG oligodeoxynucleotides as immune adjuvants (English)

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10 August 2017

Dennis M Klinman

1

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10 August 2017

Debra Currie

series ordinal

2

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10 August 2017

Ihsan Gursel

series ordinal

3

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10 August 2017

Daniela Verthelyi

series ordinal

4

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10 August 2017

publication date

1 June 2004

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10 August 2017

published in

Immunological Reviews

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10 August 2017

volume

199

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10 August 2017

page(s)

201-216

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CpG motifs in bacterial DNA trigger direct B-cell activation

10 August 2017

cites work

1 reference

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CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma

21 January 2018

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Type I interferon-mediated stimulation of T cells by CpG DNA

21 January 2018

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Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants.

21 January 2018

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Innate immunity: the virtues of a nonclonal system of recognition

21 January 2018

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Toll-like receptors: key mediators of microbe detection.

21 January 2018

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Toll receptors: a central element in innate immune responses

21 January 2018

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A Toll-like receptor recognizes bacterial DNA

21 January 2018

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Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells

21 January 2018

1 reference

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Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

21 January 2018

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Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides

21 January 2018

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CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation

21 January 2018

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

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CpG ODN-mediated regulation of IL-12 p40 transcription

21 January 2018

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Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6.

21 January 2018

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Toll-like receptors in the induction of the innate immune response

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

CpG motif identification for veterinary and laboratory species demonstrates that sequence recognition is highly conserved

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells.

21 January 2018

1 reference

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Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs

21 January 2018

1 reference

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Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

21 January 2018

1 reference

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Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells

21 January 2018

1 reference

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Identification of a novel CpG DNA class and motif that optimally stimulate B cell and plasmacytoid dendritic cell functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Mechanism and function of a newly identified CpG DNA motif in human primary B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Immunoregulatory activity of CpG oligonucleotides in humans and nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

CpG DNA overcomes hyporesponsiveness to hepatitis B vaccine in orangutans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Oligodeoxynucleotides containing CpG motifs induce low levels of TNF-alpha in human B lymphocytes: possible adjuvants for Th1 responses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Therapeutic applications of CpG-containing oligodeoxynucleotides.

21 January 2018

1 reference

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Conjugation of protein to immunostimulatory DNA results in a rapid, long-lasting and potent induction of cell-mediated and humoral immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

CpG DNA induces maturation of dendritic cells with distinct effects on nascent and recycling MHC-II antigen-processing mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Conjugation of immunostimulatory DNA to the short ragweed allergen amb a 1 enhances its immunogenicity and reduces its allergenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Local delivery of CpG oligodeoxynucleotides induces rapid changes in the genital mucosa and inhibits replication, but not entry, of herpes simplex virus type 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Immunostimulatory DNA is a potent mucosal adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Prevention of neonatal tolerance by a plasmid encoding granulocyte-macrophage colony stimulating factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Neonates mount robust and protective adult-like CD8(+)-T-cell responses to DNA vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Enhanced protection against influenza virus of mice immunized as newborns with a mixture of plasmids expressing hemagglutinin and nucleoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Synthetic oligodeoxynucleotides containing CpG motifs enhance immunogenicity of a peptide malaria vaccine in Aotus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Sustained impairment of IFN-gamma secretion in suppressed HIV-infected patients despite mature NK cell recovery: evidence for a defective reconstitution of innate immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

HIV-1/AIDS and the control of other infectious diseases in Africa

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Response to hepatitis B vaccination in a primary care setting: influence of HIV infection, CD4+ lymphocyte count and vaccination schedule

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Genetic immunization is a simple method for eliciting an immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Cellular cytotoxic response induced by DNA vaccination in HIV-1-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Reduction of antigen expression from DNA vaccines by coadministered oligodeoxynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Vaccination with plasmid DNA activates dendritic cells via Toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Enhanced cell-mediated IFN-gamma-secreting activity against the HIV-1IIIB V3 peptide of the TAB9 multiepitope after DNA vaccine backbone engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Induction of immune-mediated glomerulonephritis in normal mice immunized with bacterial DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Chlamydia infections and heart disease linked through antigenic mimicry

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Dose ranging pharmacokinetic trial of high-dose alicaforsen (intercellular adhesion molecule-1 antisense oligodeoxynucleotide) (ISIS 2302) in active Crohn's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Immune recognition of foreign DNA: a cure for bioterrorism?

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Protection of BALB/c mice against Brucella abortus 544 challenge by vaccination with bacterioferritin or P39 recombinant proteins with CpG oligodeoxynucleotides as adjuvant

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

Bacterial DNA causes septic shock

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.0105-2896.2004.00148.X

10.1111/J.0105-2896.2004.00148.X

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference