(Q35827669)

English

The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study

scientific article published in August 2006

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

histamine antagonist

1 reference

based on heuristic

inferred from title

Juan Antonio Carrillo

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

author name string

Guillermo Gervasini

1

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Sonia Vizcaino

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Maria Jesus Caballero

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Julio Benitez

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

language of work or name

0 references

publication date

1 August 2006

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

British Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

62

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

177-186

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

Effects of grapefruit juice on the multidrug transporter P-glycoprotein in the human proximal tubular cell line HK-2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Effects of grapefruit juice and orange juice components on P-glycoprotein- and MRP2-mediated drug efflux.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Genetic variability in CYP3A5 and its possible consequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

The distribution and gender difference of CYP3A activity in Chinese subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

The influence of sex on pharmacokinetics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Cloning of CYP2J2 gene and identification of functional polymorphisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Lack of gender differences and large intrasubject variability in cytochrome P450 activity measured by phenotyping with dextromethorphan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Cytochrome P-450 3A4: regulation and role in drug metabolism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents. Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Ebastine. a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

27 July 2018

Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

CYP3A4 variant alleles in white individuals with low CYP3A4 enzyme activity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

A wide interindividual variability of urinary 6beta-hydroxycortisol to free cortisol in 487 healthy Japanese subjects in near basal condition

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

The effect of CYP3A5 and MDR1 (ABCB1) polymorphisms on cyclosporine and tacrolimus dose requirements and trough blood levels in stable renal transplant patients

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2125.2006.02578.X

21 January 2018

Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

No influence of the MDR-1 C3435T polymorphism or a CYP3A4 promoter polymorphism (CYP3A4-V allele) on dose-adjusted cyclosporin A trough concentrations or rejection incidence in stable renal transplant recipients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885094

24 September 2018

Detection of MboII polymorphism at the 5' promoter region of CYP3A4

1 reference

https://pubmed.ncbi.nlm.nih.gov/16842392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of the P-glycoprotein transporter MDR1(C3435T) polymorphism with the susceptibility to renal epithelial tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/16842392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CYP3A5 variant allele frequencies in Dutch Caucasians

1 reference

https://pubmed.ncbi.nlm.nih.gov/16842392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/16842392

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2125.2006.02578.X

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16842392%20AND%20SRC:MED&resulttype=core&format=json

27 December 2019

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