(Q35840838)

English

MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments

scientific article published on 26 October 2011

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

MTRX1011A, a humanized anti-CD4 monoclonal antibody, in the treatment of patients with rheumatoid arthritis: a phase I randomized, double-blind, placebo-controlled study incorporating pharmacodynamic biomarker assessments (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

0 references

0 references

rheumatoid arthritis

1 reference

based on heuristic

inferred from title

pharmacodynamics

1 reference

based on heuristic

inferred from title

author name string

Heleen Scheerens

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Zheng Su

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Bryan Irving

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Michael J Townsend

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Yanan Zheng

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Eric Stefanich

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Vishala Chindalore

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Clifton O Bingham

8

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

John C Davis

9

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

publication date

26 October 2011

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Arthritis Research and Therapy

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

13

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

R177

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

copyright license

Creative Commons Attribution 2.0 Generic

1 October 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Selective modulation of T-cell co-stimulation: a novel mode of action for the treatment of rheumatoid arthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Functional characterization of N297A, a murine surrogate for low-Fc binding anti-human CD3 antibodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Immunology. Sugar determines antibody activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Pharmacokinetics/pharmacodynamics of nondepleting anti-CD4 monoclonal antibody (TRX1) in healthy human volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with Behçet's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Tumor necrosis factor-alpha antagonists for the treatment of rheumatic diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Interstitial granulomatous dermatitis with cutaneous cords and arthritis: a disorder associated with autoantibodies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Association of MHC and rheumatoid arthritis. HLA-DR4 and rheumatoid arthritis: studies in mice and men

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Pharmacokinetic, pharmacodynamic and clinical effects of a humanized IgG1 anti-CD4 monoclonal antibody in the peripheral blood and synovial fluid of rheumatoid arthritis patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Treatment with depleting CD4 monoclonal antibody results in a preferential loss of circulating naive T cells but does not affect IFN-gamma secreting TH1 cells in humans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Abnormal distribution of the helper-inducer and suppressor-inducer T-lymphocyte subsets in the rheumatoid joint.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Selective migration of the human helper-inducer memory T cell subset: confirmation byin vivo cellular kinetic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Therapy with monoclonal antibodies. An in vivo model for the assessment of therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Multiple binding sites on the CH2 domain of IgG for mouse Fc gamma R11.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

11 July 2018

Long-term infliximab treatment in rheumatoid arthritis: subsequent outcome of initial responders.

1 reference

https://api.crossref.org/works/10.1186%2FAR3502

21 January 2018

Translational pharmacokinetics and pharmacodynamics of an FcRn-variant anti-CD4 monoclonal antibody from preclinical model to phase I study

1 reference

https://api.crossref.org/works/10.1186%2FAR3502

21 January 2018

The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease

1 reference

https://api.crossref.org/works/10.1186%2FAR3502

21 January 2018

CD4 coating, but not CD4 depletion, is a predictor of efficacy with primatized monoclonal anti-CD4 treatment of active rheumatoid arthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3308112

24 September 2018

Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeat-cycle study of high-dose intravenous 4162W94 anti-CD4 humanized monoclonal antibody in rheumatoid arthritis. A randomized placebo-controlled trial

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Soluble CD4 in patients with rheumatoid arthritis and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of refractory rheumatoid arthritis with a chimeric anti-CD4 monoclonal antibody. Long-term followup of CD4+ T cell counts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A randomized, double‐blind, placebo‐controlled study of cd4 monoclonal antibody therapy in early rheumatoid arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Percentage of anti-CD4 monoclonal antibody-coated lymphocytes in the rheumatoid joint is associated with clinical improvement. Implications for the development of immunotherapeutic dosing regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22029963

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

0 references

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