(Q35842532)

10 August 2017

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title

Cephalosporins in clinical development (English)

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10 August 2017

Malcolm G P Page

1

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10 August 2017

language of work or name

English

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publication date

1 August 2004

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Expert Opinion on Investigational Drugs

10 August 2017

published in

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10 August 2017

volume

13

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10 August 2017

issue

8

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10 August 2017

page(s)

973-985

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The structure of cephalesporin C

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

The x-ray analysis of the structure of cephalosporin C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

An audit of first generation cephalosporin usage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Antibiotic usage and methicillin-resistant Staphylococcus aureus: an analysis of causality.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Restriction of third-generation cephalosporin use decreases infection-related mortality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Molecular structures of penicillin-binding proteins and beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Triggering of autolytic cell wall degradation in Escherichia coli by beta-lactam antibiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Bacterial walls, peptidoglycan hydrolases, autolysins, and autolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Programmed death in bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

A new type of penicillin resistance of Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Differential antibiotic-induced endotoxin release in severe melioidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Pseudomonas aeruginosa reveals high intrinsic resistance to penem antibiotics: penem resistance mechanisms and their interplay

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Prevention of drug access to bacterial targets: permeability barriers and active efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

The bacterial outer membrane as a drug barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

A new mechanism of antibiotic resistance in Enterobacteriaceae induced by a structural modification of the major porin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vivo modification of porin activity conferring antibiotic resistance to Enterobacter aerogenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Role of efflux pump(s) in intrinsic resistance of Pseudomonas aeruginosa: active efflux as a contributing factor to beta-lactam resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Extrusion of penem antibiotics by multicomponent efflux systems MexAB-OprM, MexCD-OprJ, and MexXY-OprM of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

SmeC, an outer membrane multidrug efflux protein of Stenotrophomonas maltophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Contributions of the AmpC beta-lactamase and the AcrAB multidrug efflux system in intrinsic resistance of Escherichia coli K-12 to beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

A functional classification scheme for beta-lactamases and its correlation with molecular structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

The structure of β-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

A standard numbering scheme for the class A beta-lactamases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Susceptibility and bactericidal activity studies of four beta-lactamase-producing enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Molecular epidemiology of beta-lactamase-producing enterococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Penicillin-binding proteins and ampicillin resistance in Haemophilus influenzae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

beta-Lactam-resistant Pseudomonas aeruginosa with modified penicillin-binding proteins emerging during cystic fibrosis treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Insensitivity of peptidoglycan biosynthetic reactions to beta-lactam antibiotics in a clinical isolate of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Carbenicillin resistance of Pseudomonas aeruginosa

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Imipenem resistance in Acinetobacter baumanii is due to altered penicillin-binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Transition from resistance to hypersusceptibility to beta-lactam antibiotics associated with loss of a low-affinity penicillin-binding protein in a Streptococcus faecium mutant highly resistant to penicillin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Penicillin-binding proteins in Streptococcus faecalis and S. faecium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Penicillin-binding protein 5 sequence alterations in clinical isolates of Enterococcus faecium with different levels of beta-lactam resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Role of penicillin-binding protein 5 in expression of ampicillin resistance and peptidoglycan structure in Enterococcus faecium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Penicillin-binding proteins of penicillin-susceptible and intrinsically resistant Neisseria gonorrhoeae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Genetic analysis and penicillin-binding protein alterations in Neisseria gonorrhoeae with chromosomally mediated resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Hybrid penicillin-binding proteins in penicillin-resistant strains of Neisseria gonorrhoeae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Relative penicillin G resistance in Neisseria meningitidis and reduced affinity of penicillin-binding protein 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Genetic diversity of penicillin-binding protein 2 genes of penicillin-resistant strains of Neisseria meningitidis revealed by fingerprinting of amplified DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Penicillin-binding protein families: evidence for the clonal nature of penicillin resistance in clinical isolates of pneumococci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -inte

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Factors influencing methicillin resistance in staphylococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Methicillin resistance in Staphylococcus aureus: mechanisms and modulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

AS-924, a novel, orally active, bifunctional prodrug of ceftizoxime: physicochemical properties, oral absorption in animals, and antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

TOC-39, a novel parenteral broad-spectrum cephalosporin with excellent activity against methicillin-resistant Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activity of cephalosporin RWJ-54428 (MC-02479) against multidrug-resistant gram-positive cocci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

TAK-599, a novel N-Phosphono type prodrug of anti-MRSA cephalosporin T-91825: synthesis, physicochemical and pharmacological properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Novel antibacterial agents for the treatment of serious Gram-positive infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3-ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant staphylococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro evaluation of BAL9141, a novel parenteral cephalosporin active against oxacillin-resistant staphylococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activity of S-3578, a new broad-spectrum cephalosporin active against methicillin-resistant staphylococci

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activity of a new cephalosporin, RWJ-54428, against streptococci, enterococci and staphylococci, including glycopeptide-intermediate Staphylococcus aureus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activities of RWJ-54428 (MC-02,479) against multiresistant gram-positive bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

PBP 2a mutations producing very-high-level resistance to beta-lactams

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activity of BAL9141 against clinical isolates of gram-negative bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro activities of BAL9141, a novel broad-spectrum pyrrolidinone cephalosporin, against gram-negative nonfermenters

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

BAL 9141, a new broad-spectrum pyrrolidinone cephalosporin: activity against clinically significant anaerobes in comparison with 10 other antimicrobials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vitro anti-anaerobic activity of the cephalosporin derivative RWJ 54428, compared to seven other compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Single-dose pharmacokinetics and safety of a novel broad-spectrum cephalosporin (BAL5788) in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Use of Monte Carlo simulations to select therapeutic doses and provisional breakpoints of BAL9141.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

Pharmacodynamics of S-3578, a novel cephem, in murine lung and systemic infection models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

In vivo antibacterial activity of S-3578, a new broad-spectrum cephalosporin: methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa experimental infection models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.8.973

10.1517/13543784.13.8.973

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference