(Q35852274)

10 August 2017

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title

Helping the CD8(+) T-cell response (English)

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10 August 2017

Michael J Bevan

1

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10 August 2017

1 August 2004

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Nature Reviews Immunology

10 August 2017

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10 August 2017

4

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10 August 2017

8

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10 August 2017

595-602

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Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection.

10 August 2017

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Massive expansion of antigen-specific CD8+ T cells during an acute virus infection

31 March 2020

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The numbers game for virus-specific CD8+ T cells

31 March 2020

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Direct visualization of antigen-specific CD8+ T cells during the primary immune response to Epstein-Barr virus In vivo

31 March 2020

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Mini‐review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross‐priming and direct priming?

31 March 2020

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Quantitative studies on the mixed lymphocyte interaction in rats. 3. Kinetics of the response

31 March 2020

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Genetic and cellular aspects of xenogeneic mixed leukocyte culture reaction

31 March 2020

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Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

31 March 2020

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Linked recognition of helper and cytotoxic antigenic determinants for the generation of cytotoxic T lymphocytes

31 March 2020

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Cooperation between helper T cells and cytotoxic T lymphocyte precursors

31 March 2020

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A fail-safe mechanism for maintaining self-tolerance

31 March 2020

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Three-cell-type clusters of T cells with antigen-presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

31 March 2020

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Induction of a CD8+ cytotoxic T lymphocyte response by cross-priming requires cognate CD4+ T cell help

31 March 2020

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.

31 March 2020

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling.

31 March 2020

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.

31 March 2020

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Signal 3 determines tolerance versus full activation of naive CD8 T cells: dissociating proliferation and development of effector function

31 March 2020

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Uncoupling of proliferative potential and gain of effector function by CD8(+) T cells responding to self-antigens.

31 March 2020

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Induction of cytotoxic T-cell responses in vivo in the absence of CD4 helper cells

31 March 2020

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Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4

31 March 2020

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Viral induction of co-stimulatory activity on antigen-presenting cells bypasses the need for CD4+ T-cell help in CD8+ T-cell responses

31 March 2020

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A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory

31 March 2020

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CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

31 March 2020

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The number of long-lasting functional memory CD8+ T cells generated depends on the nature of the initial nonspecific stimulation.

31 March 2020

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Requirement for CD4 T Cell Help in Generating Functional CD8 T Cell Memory

31 March 2020

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Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

31 March 2020

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Early programming of T cell populations responding to bacterial infection

31 March 2020

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

31 March 2020

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Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

31 March 2020

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Dynamic programming of CD8+ T lymphocyte responses

31 March 2020

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Programmed contraction of CD8(+) T cells after infection.

31 March 2020

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CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.

31 March 2020

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Compromised influenza virus-specific CD8(+)-T-cell memory in CD4(+)-T-cell-deficient mice

31 March 2020

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CD4 T cell-dependent CD8 T cell maturation

31 March 2020

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The role of programming in memory T-cell development

31 March 2020

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Cutting edge: CD4+ T cell help can be essential for primary CD8+ T cell responses in vivo.

31 March 2020

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Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cells.

31 March 2020

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Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

31 March 2020

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Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation

31 March 2020

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Cutting edge: naive T cells masquerading as memory cells

31 March 2020

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Naïve cytotoxic T lymphocytes spontaneously acquire effector function in lymphocytopenic recipients: A pitfall for T cell memory studies?

31 March 2020

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Homeostasis-stimulated proliferation drives naive T cells to differentiate directly into memory T cells

31 March 2020

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CD8(+) T cells mediate CD40-independent maturation of dendritic cells in vivo

31 March 2020

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Multiple paths for activation of naive CD8+ T cells: CD4-independent help

31 March 2020

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Cutting Edge: Precursor Frequency Affects the Helper Dependence of Cytotoxic T Cells

31 March 2020

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CD8 lethargy in the absence of CD4 help.

31 March 2020

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CD8 and B cell memory: same strategy, same signals

31 March 2020

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CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environment

31 March 2020

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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells.

31 March 2020

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Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets

31 March 2020

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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice

31 March 2020

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Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells

31 March 2020

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Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells

31 March 2020

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Cytokine requirements for acute and Basal homeostatic proliferation of naive and memory CD8+ T cells

31 March 2020

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IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation

31 March 2020

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Cytokine control of memory T-cell development and survival

31 March 2020

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Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

31 March 2020

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Molecular and functional profiling of memory CD8 T cell differentiation.

31 March 2020

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Lineage relationship and protective immunity of memory CD8 T cell subsets

31 March 2020

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Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

31 March 2020

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Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells

31 March 2020

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Viral immune evasion due to persistence of activated T cells without effector function

31 March 2020

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Assessing CD8 T cell number and dysfunction in the presence of antigen

31 March 2020

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Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes.

31 March 2020

1 reference

Role of CD40 Ligand and CD28 in Induction and Maintenance of Antiviral CD8+ Effector T Cell Responses

31 March 2020

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HCV Persistence and Immune Evasion in the Absence of Memory T Cell Help

31 March 2020

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Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.

31 March 2020

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HIV-1 viremia prevents the establishment of interleukin 2-producing HIV-specific memory CD4+ T cells endowed with proliferative capacity

31 March 2020

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Progress in defining CD4 helper cell responses in chronic viral infections

31 March 2020

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Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain

31 March 2020

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Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

31 March 2020

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Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment

31 March 2020

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Interleukin-2 programs mouse alpha beta T lymphocytes for apoptosis

31 March 2020

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Homeostasis and self-tolerance in the immune system: turning lymphocytes off.

31 March 2020

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Regulatory T cells in autoimmmunity*.

31 March 2020

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Regulatory T cells: key controllers of immunologic self-tolerance

31 March 2020

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Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms

31 March 2020

1 reference

Homeostasis of peripheral CD4+ T cells: IL-2R alpha and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers

31 March 2020

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Normal lymphoid homeostasis and lack of lethal autoimmunity in mice containing mature T cells with severely impaired IL-2 receptors

31 March 2020

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CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2

31 March 2020

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CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

31 March 2020

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IL-2 is not required for the initiation of CD8 T cell cycling but sustains expansion

31 March 2020

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Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses.

31 March 2020

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Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4.

31 March 2020

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Helper T cells without CD4: control of leishmaniasis in CD4-deficient mice

31 March 2020

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The CD8 population in CD4-deficient mice is heavily contaminated with MHC class II-restricted T cells

31 March 2020

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Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.

31 March 2020

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Mice lacking MHC class II molecules

31 March 2020

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The danger model: a renewed sense of self

31 March 2020

1 reference

Toll receptor families: structure and function.

31 March 2020

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Recognition of microbial infection by Toll-like receptors

31 March 2020

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Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors

31 March 2020

1 reference

Molecular identification of a danger signal that alerts the immune system to dying cells

31 March 2020

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Death-defying immunity: do apoptotic cells influence antigen processing and presentation?

31 March 2020

1 reference

CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.

31 March 2020

1 reference

CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice.

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI1413

1 reference

10 August 2017

1 reference

PubMed ID

15286726