(Q35858087)

English

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy.

scientific article published on 26 March 2012

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22446185%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy (English)

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26 January 2020

pathophysiology

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Dominik J. Schaer

7

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26 January 2020

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Jin Hyen Baek

1

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26 January 2020

Felice D'Agnillo

2

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26 January 2020

Florence Vallelian

3

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26 January 2020

Claudia P Pereira

4

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26 January 2020

Matthew C Williams

5

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26 January 2020

Yiping Jia

6

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26 January 2020

Paul W Buehler

8

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26 January 2020

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publication date

26 March 2012

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26 January 2020

Journal of Clinical Investigation

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26 January 2020

122

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26 January 2020

4

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26 January 2020

1444-1458

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26 January 2020

Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Rapid clearance of transfused murine red blood cells is associated with recipient cytokine storm and enhanced alloimmunogenicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Storage lesion: role of red blood cell breakdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Eculizumab prevents intravascular hemolysis in patients with paroxysmal nocturnal hemoglobinuria and unmasks low-level extravascular hemolysis occurring through C3 opsonization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

A novel mouse model of red blood cell storage and posttransfusion in vivo survival.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Vascular dysfunction in a murine model of severe hemolysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Inhaled nitric oxide enables artificial blood transfusion without hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Duration of red-cell storage and complications after cardiac surgery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Lowering of blood pressure by increasing hematocrit with non nitric oxide scavenging red blood cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Review of hemoglobin-induced myocardial lesions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Differences in the Interaction of 2,3-Diphosphoglycerate with Certain Mammalian Hemoglobins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Changes in physical properties of stored erythrocytes relationship to survival in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Reaction of nitric oxide with heme proteins and model compounds of hemoglobin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Molecular basis of complement C3 deficiency in guinea pigs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

11 July 2018

Susceptibility to hyperosmotic stress-induced phosphatidylserine exposure increases during red blood cell storage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

24 September 2018

Association of mortality with age of blood transfused in septic ICU patients.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3314461

24 September 2018

Age of transfused blood is an independent risk factor for postinjury multiple organ failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free hemoglobin concentrations in patients receiving massive blood transfusion during emergency surgery for trauma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the preservation of human blood. II. The relationship of erythrocyte adenosine triphosphate levels and other in vitro measures to red cell storageability

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of hemoglobinuria by administration of haptoglobin

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Erythrocyte membrane vesiculation and changes in membrane composition during storage in citrate-phosphate-dextrose-adenine-1

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of reduced red cell deformability on regional blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathogenetic mechanisms in experimental hemoglobinuric acute renal failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Massive blood transfusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Naturally occurring human anti-band 3 autoantibodies accelerate clearance of erythrocytes in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Permeability characteristics of hemoglobin derivatives across cultured endothelial cell monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

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based on heuristic

inferred from PubMed ID database lookup

The blood volume of the normal guinea-pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig

1 reference

https://pubmed.ncbi.nlm.nih.gov/22446185

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1172/JCI59770

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22446185%20AND%20SRC:MED&resulttype=core&format=json

26 January 2020

release_625wcrwslrgjfj3glcwqvqvqwe

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24 November 2022

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26 January 2020

PubMed publication ID

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Europe PubMed Central

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26 January 2020

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