(Q35869232)

English

Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway.

scientific article published on 10 November 2009

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scholarly article

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12 February 2020

Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway (English)

1 reference

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12 February 2020

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El-Shaimaa A Arafa

1

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12 February 2020

author name string

Qianzheng Zhu

2

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12 February 2020

Bassant M Barakat

3

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12 February 2020

Gulzar Wani

4

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12 February 2020

Qun Zhao

5

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12 February 2020

Mohamed A El-Mahdy

6

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12 February 2020

Altaf A Wani

7

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12 February 2020

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publication date

10 November 2009

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12 February 2020

Cancer Research

1 reference

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12 February 2020

69

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12 February 2020

23

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12 February 2020

8910-8917

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903849%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

Methoxylated flavones, a superior cancer chemopreventive flavonoid subclass?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Tangeretin and nobiletin induce G1 cell cycle arrest but not apoptosis in human breast and colon cancer cells

1 reference

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11 July 2018

Tangeretin suppresses IL-1beta-induced cyclooxygenase (COX)-2 expression through inhibition of p38 MAPK, JNK, and AKT activation in human lung carcinoma cells

1 reference

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11 July 2018

Cisplatin-induced apoptosis in human promyelocytic leukemia cells.

1 reference

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The anti-death machinery in IKK/NF-kappaB signaling

1 reference

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11 July 2018

Proteins associated with Cisplatin resistance in ovarian cancer cells identified by quantitative proteomic technology and integrated with mRNA expression levels

1 reference

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11 July 2018

IKK/NF-kappaB signaling: balancing life and death--a new approach to cancer therapy

1 reference

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11 July 2018

Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells

1 reference

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11 July 2018

Mechanisms of platinum drug resistance

1 reference

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11 July 2018

The epigenetics of ovarian cancer drug resistance and resensitization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

PI3K/Akt and apoptosis: size matters

1 reference

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11 July 2018

Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.

1 reference

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11 July 2018

Tissue distribution and neuroprotective effects of citrus flavonoid tangeretin in a rat model of Parkinson's disease

1 reference

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11 July 2018

Flavonoids: a review of probable mechanisms of action and potential applications

1 reference

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11 July 2018

Cytotoxic mechanism of flavonoid from Temu Kunci (Kaempferia pandurata) in cell culture of human mammary carcinoma.

1 reference

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11 July 2018

Quercetin-induced apoptosis in the monoblastoid cell line U937 in vitro and the regulation of heat shock proteins expression

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11 July 2018

Flavonoids inhibit cell growth and induce apoptosis in B16 melanoma 4A5 cells

1 reference

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11 July 2018

Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells

1 reference

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Topoisomerase I poisons and suppressors as anticancer drugs

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11 July 2018

Signal pathways involved in apigenin inhibition of growth and induction of apoptosis of human anaplastic thyroid cancer cells (ARO).

1 reference

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11 July 2018

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Cisplatin- and paclitaxel-induced apoptosis of ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Citrus flavone tangeretin inhibits leukaemic HL-60 cell growth partially through induction of apoptosis with less cytotoxicity on normal lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

11 July 2018

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II

1 reference

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11 July 2018

Antiproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro

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11 July 2018

Oncogenes and signal transduction

1 reference

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11 July 2018

Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells

1 reference

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24 September 2018

A safety study of oral tangeretin and xanthohumol administration to laboratory mice

1 reference

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24 September 2018

Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

24 September 2018

Tangeretin induces cell-cycle G1 arrest through inhibiting cyclin-dependent kinases 2 and 4 activities as well as elevating Cdk inhibitors p21 and p27 in human colorectal carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3319094

24 September 2018

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

1 reference

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Cisplatin, camptothecin, and taxol sensitivities of cells with p53-associated multidrug resistance

1 reference

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14 November 2018

A Bad kinase makes good

1 reference

https://pubmed.ncbi.nlm.nih.gov/19903849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19903849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of a cis-diamminedichloroplatinum(II)-resistant human ovarian cancer cell line and its use in evaluation of platinum analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/19903849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Apoptosis meets signal transduction: elimination of a BAD influence

1 reference

https://pubmed.ncbi.nlm.nih.gov/19903849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1158/0008-5472.CAN-09-1543

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903849%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19903849%20AND%20SRC:MED&resulttype=core&format=json

12 February 2020

1 reference

Europe PubMed Central

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12 February 2020

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