(Q35871689)

English

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge

scientific article published on 24 December 2008

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

A genital tract peptide epitope vaccine targeting TLR-2 efficiently induces local and systemic CD8+ T cells and protects against herpes simplex virus type 2 challenge (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

sexual transmission

0 references

toll-like receptor

0 references

author name string

X Zhang

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

A A Chentoufi

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

G Dasgupta

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

A B Nesburn

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

M Wu

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

X Zhu

6

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

D Carpenter

7

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

S L Wechsler

8

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

S You

9

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

L BenMohamed

10

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

publication date

24 December 2008

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Europe PubMed Central

PMC publication ID

10 August 2017

Mucosal Immunology

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Europe PubMed Central

PMC publication ID

10 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

129-143

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

https://scigraph.springernature.com/pub.10.1038/mi.2008.81

0 references

Immunodominant epitopes in herpes simplex virus type 2 glycoprotein D are recognized by CD4 lymphocytes from both HSV-1 and HSV-2 seropositive subjects

1 reference

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Asymptomatic human CD4+ cytotoxic T-cell epitopes identified from herpes simplex virus glycoprotein B

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Replication-defective virus vaccine-induced protection of mice from genital herpes simplex virus 2 requires CD4 T cells

1 reference

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Self-adjuvanting lipopeptide vaccines.

1 reference

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Quantification and comparison of toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia

1 reference

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The role of toll-like receptor ligands/agonists in protection against genital HSV-2 infection.

1 reference

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Recent advances with TLR2-targeting lipopeptide-based vaccines

1 reference

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Functional Foxp3+ CD4+ CD25(Bright+) "natural" regulatory T cells are abundant in rabbit conjunctiva and suppress virus-specific CD4+ and CD8+ effector T cells during ocular herpes infection.

1 reference

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The genital tract immune milieu: an important determinant of HIV susceptibility and secondary transmission.

1 reference

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Topical/mucosal delivery of sub-unit vaccines that stimulate the ocular mucosal immune system

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New CD4+ and CD8+ T cell responses induced in chronically HIV type-1-infected patients after immunizations with an HIV type 1 lipopeptide vaccine

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Mucosal administration of CpG oligodeoxynucleotide elicits strong CC and CXC chemokine responses in the vagina and serves as a potent Th1-tilting adjuvant for recombinant gD2 protein vaccination against genital herpes

1 reference

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Clinical safety of HIV lipopeptides used as vaccines in healthy volunteers and HIV-infected adults

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Vaccines for herpes simplex virus infections

1 reference

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Role of mucosal immunity in preventing genital herpes infection

1 reference

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Th-cytotoxic T-lymphocyte chimeric epitopes extended by Nepsilon-palmitoyl lysines induce herpes simplex virus type 1-specific effector CD8+ Tc1 responses and protect against ocular infection

1 reference

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Plasmacytoid DCs help lymph node DCs to induce anti-HSV CTLs

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Induction of tumor necrosis factor- alpha secretion and toll-like receptor 2 and 4 mRNA expression by genital mucosal fluids from women with bacterial vaginosis

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Immunologic uniqueness of the genital tract: challenge for vaccine development

1 reference

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Homing in on the cellular immune response to HSV-2 in humans.

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Genital herpes and human immunodeficiency virus: double trouble

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Clinical trials of prophylactic and therapeutic herpes simplex virus vaccines

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Long-term multiepitopic cytotoxic-T-lymphocyte responses induced in chimpanzees by combinations of Plasmodium falciparum liver-stage peptides and lipopeptides

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Molecular adjuvants for mucosal immunity

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Immunity to latent viral infection: many skirmishes but few fatalities

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Long-term specific immune responses induced in humans by a human immunodeficiency virus type 1 lipopeptide vaccine: characterization of CD8+-T-cell epitopes recognized.

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CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses

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Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2.

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Identification of novel immunodominant CD4+ Th1-type T-cell peptide epitopes from herpes simplex virus glycoprotein D that confer protective immunity

1 reference

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Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2

1 reference

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A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection

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Use of immunostimulatory sequence-containing oligonucleotides as topical therapy for genital herpes simplex virus type 2 infection

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Immunization for protection of the reproductive tract: a review

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Lipopeptide vaccines--yesterday, today, and tomorrow

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Intranasal administration of a synthetic lipopeptide without adjuvant induces systemic immune responses

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Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling

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Systemic and mucosal immune responses in mice after rectal and vaginal immunization with HIV-DNA vaccine

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Toll-like receptors: critical proteins linking innate and acquired immunity

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Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract

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CD4 T-cell responses to herpes simplex virus type 2 major capsid protein VP5: comparison with responses to tegument and envelope glycoproteins

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Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response.

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Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring

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Recognition of herpes simplex virus type 2 tegument proteins by CD4 T cells infiltrating human genital herpes lesions

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Long-term immunity and protection against herpes simplex virus type 2 in the murine female genital tract after mucosal but not systemic immunization

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Clearance of HSV-2 from recurrent genital lesions correlates with infiltration of HSV-specific cytotoxic T lymphocytes

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Antigenic specificities of human CD4+ T-cell clones recovered from recurrent genital herpes simplex virus type 2 lesions.

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Human cytotoxic T cell clones directed against herpes simplex virus-infected cells. IV. Recognition and activation by cloned glycoproteins gB and gD.

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Asymptomatic reactivation of herpes simplex virus in women after the first episode of genital herpes

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Human CD8+ herpes simplex virus-specific cytotoxic T-lymphocyte clones recognize diverse virion protein antigens

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HLA-A*0201-restricted CD8+ cytotoxic T lymphocyte epitopes identified from herpes simplex virus glycoprotein D.

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HLA-DR-restricted peptides identified in the Nef protein can induce HIV type 1-specific IL-2/IFN-gamma-secreting CD4+ and CD4+ /CD8+ T cells in humans after lipopeptide vaccination.

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Human male genital tract secretions: both mucosal and systemic immune compartments contribute to the humoral immunity.

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The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells.

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T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice

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Systemic immune responses induced by mucosal administration of lipopeptides without adjuvant

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Development of HSV-specific CD4+ Th1 responses and CD8+ cytotoxic T lymphocytes with antiviral activity by vaccination with the HSV-2 mutant ICP10DeltaPK.

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Protection against Plasmodium falciparum malaria in chimpanzees by immunization with the conserved pre-erythrocytic liver-stage antigen 3.

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Memory-type CD8+ T cells protect IL-2 receptor alpha-deficient mice from systemic infection with herpes simplex virus type 2.

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Antigen-specific T cells localize to the uterine cervix in women with genital herpes simplex virus type 2 infection.

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High immunogenicity in chimpanzees of peptides and lipopeptides derived from four new Plasmodium falciparum pre-erythrocytic molecules

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Limited antibody-dependent cellular cytotoxicity antibody response induced by a herpes simplex virus type 2 subunit vaccine

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A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group

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T lymphocytes are required for protection of the vaginal mucosae and sensory ganglia of immune mice against reinfection with herpes simplex virus type 2.

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Role of mucosal immunity in herpes simplex virus infection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

24 September 2018

Herpes simplex virus type 1 glycoproteins gB, gC and gD are major targets for CD4 T-lymphocyte cytotoxicity in HLA-DR expressing human epidermal keratinocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

24 September 2018

Lipopeptide immunization without adjuvant induces potent and long-lasting B, T helper, and cytotoxic T lymphocyte responses against a malaria liver stage antigen in mice and chimpanzees

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

24 September 2018

Herpes simplex virus type 2 infection of heterosexual men attending a sexual health centre

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

24 September 2018

A mouse model for studies of mucosal immunity to vaginal infection by herpes simplex virus type 2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

24 September 2018

Intranasal Vaccination with a Lipopeptide Containing a Conformationally Constrained Conserved Minimal Peptide, a Universal T Cell Epitope, and a Self‐Adjuvanting Lipid Protects Mice from Group A Streptococcus Challenge and Reduces Throat Colonizati

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4509510

14 November 2018

TLR2 engagement on CD8 T cells lowers the thresholdfor optimal antigen-induced T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunogenicity evaluation of DNA vaccines that target guinea pig cytomegalovirus proteins glycoprotein B and UL83

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential induction of mucosal and systemic antibody responses in women after nasal, rectal, or vaginal immunization: influence of the menstrual cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased levels of IFN-gamma in the trigeminal ganglion correlate with protection against HSV-1-induced encephalitis following subcutaneous administration with androstenediol

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of toll-like receptor (TLR) agonists on TLR and microbicide expression in uterine and vaginal tissues of the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of myeloid differentiation factor 88 in innate and acquired immune protection against genital herpes infection in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection against mucosal viral infection in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge

1 reference

https://pubmed.ncbi.nlm.nih.gov/19129756

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/MI.2008.81

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Dimensions Publication ID

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

ResearchGate publication ID

0 references

Sitelinks

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