(Q35897754)

English

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus

scientific article published in July 2015

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Reversal of Aging-Related Neuronal Ca2+ Dysregulation and Cognitive Impairment by Delivery of a Transgene Encoding FK506-Binding Protein 12.6/1b to the Hippocampus (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

cognitive dysfunction

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based on heuristic

inferred from title

author name string

John C Gant

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kuey-Chu Chen

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Inga Kadish

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Eric M Blalock

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Olivier Thibault

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Nada M Porter

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Philip W Landfield

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

0 references

publication date

1 July 2015

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Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Neuroscience

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Europe PubMed Central

PMC publication ID

11 August 2017

35

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Europe PubMed Central

PMC publication ID

11 August 2017

30

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

10878-10887

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Dual transgene expression in murine cerebellar Purkinje neurons by viral transduction in vivo

1 reference

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Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5--implications for dementia with Lewy bodies

1 reference

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Adeno-associated virus serotypes 1, 8, and 9 share conserved mechanisms for anterograde and retrograde axonal transport.

1 reference

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27 July 2018

FK506-binding protein 1b/12.6: a key to aging-related hippocampal Ca2+ dysregulation?

1 reference

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1 reference

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FKBPs and the Akt/mTOR pathway

1 reference

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Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons

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FK506 binding proteins: cellular regulators of intracellular Ca2+ signalling

1 reference

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Epidemiology of Alzheimer disease

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Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice

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Age-related increase of sIAHP in prefrontal pyramidal cells of monkeys: relationship to cognition

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mTOR signaling: at the crossroads of plasticity, memory and disease

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Hippocampal and cognitive aging across the lifespan: a bioenergetic shift precedes and increased cholesterol trafficking parallels memory impairment

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Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

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FKBP family proteins: immunophilins with versatile biological functions

1 reference

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Alterations in intrinsic neuronal excitability during normal aging.

1 reference

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Modulation of the ryanodine receptor and intracellular calcium

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Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS.

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Impact of aging on hippocampal function: plasticity, network dynamics, and cognition

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Interaction between synaptic excitation and slow afterhyperpolarization current in rat hippocampal pyramidal cells

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Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity

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The use of animal models to study the effects of aging on cognition

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Neurobiological bases of age-related cognitive decline in the rhesus monkey.

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'Increased calcium-current' hypothesis of brain aging

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Calcium and the aging nervous system

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Brain spectrin, calpain and long-term changes in synaptic efficacy

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Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation

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The role of calcium regulation in brain aging: reexamination of a hypothesis

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L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner

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Disrupting function of FK506-binding protein 1b/12.6 induces the Ca²+-dysregulation aging phenotype in hippocampal neurons

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Life and death of neurons in the aging cerebral cortex

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Mechanisms underlying activation of the slow AHP in rat hippocampal neurons.

1 reference

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1 reference

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Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-induced Ca2+ release.

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The slow afterhyperpolarization in hippocampal CA1 neurons covaries with spatial learning ability in aged Fisher 344 rats.

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.1248-15.2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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