(Q35906116)

11 August 2017

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title

Glycomics: a pathway to a class of new and improved therapeutics (English)

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11 August 2017

Zachary Shriver

1

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11 August 2017

S Raguram

series ordinal

2

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11 August 2017

Ram Sasisekharan

series ordinal

3

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11 August 2017

publication date

1 October 2004

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Nature Reviews Drug Discovery

11 August 2017

published in

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11 August 2017

volume

3

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11 August 2017

issue

10

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11 August 2017

page(s)

863-873

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Transfection of a human gene that corrects the Lec1 glycosylation defect: evidence for transfer of the structural gene for N-acetylglucosaminyltransferase I.

11 August 2017

cites work

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Specificities of heparan sulphate proteoglycans in developmental processes

21 January 2018

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Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates

31 March 2020

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The anticoagulant activation of antithrombin by heparin

31 March 2020

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Antibiotic optimization via in vitro glycorandomization

31 March 2020

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Heparan sulfate proteoglycans: intricate molecules with intriguing functions.

31 March 2020

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Glycosylation and the immune system

31 March 2020

1 reference

Glycobiology. Turning sweet on cancer

31 March 2020

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A genetic approach to Mammalian glycan function

31 March 2020

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Sulfotransferases in glycosaminoglycan biosynthesis

31 March 2020

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N-glycan branching requirement in neuronal and postnatal viability

31 March 2020

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Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation

31 March 2020

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Molecular cloning and expression of cDNA encoding the rat UDP-N-acetylglucosamine:alpha-6-D-mannoside beta-1,2-N-acetylglucosaminyltransferase II

31 March 2020

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Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis

31 March 2020

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Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin

31 March 2020

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Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization

31 March 2020

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New animal lectin structures

31 March 2020

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Mechanism of heparin activation of antithrombin. Role of individual residues of the pentasaccharide activating sequence in the recognition of native and activated states of antithrombin.

31 March 2020

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Structure and function of the mannose 6-phosphate/insulinlike growth factor II receptors

31 March 2020

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The asialoglycoprotein receptor: relationships between structure, function, and expression

31 March 2020

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Synthesis of a multivalent display of a CD22-binding trisaccharide

31 March 2020

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Syndecans in inflammation

31 March 2020

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Sulphated endothelial ligands for L-selectin in lymphocyte homing and inflammation

31 March 2020

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Ammonium alters N-glycan structures of recombinant TNFR-IgG: degradative versus biosynthetic mechanisms

31 March 2020

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Metabolic control of recombinant protein N-glycan processing in NS0 and CHO cells

31 March 2020

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Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms.

31 March 2020

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Effect of ammonia on the glycosylation of human recombinant erythropoietin in culture

31 March 2020

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Effect of shear stress on intrinsic CHO culture state and glycosylation of recombinant tissue-type plasminogen activator protein.

31 March 2020

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Production of a complement inhibitor possessing sialyl Lewis X moieties by in vitro glycosylation technology

31 March 2020

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Engineering Chinese hamster ovary cells to maximize sialic acid content of recombinant glycoproteins

31 March 2020

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Stable expression of human alpha-2,6-sialyltransferase in Chinese hamster ovary cells: functional consequences for human erythropoietin expression and bioactivity

31 March 2020

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Complex-type biantennary N-glycans of recombinant human transferrin from Trichoplusia ni insect cells expressing mammalian [beta]-1,4-galactosyltransferase and [beta]-1,2-N-acetylglucosaminyltransferase II.

31 March 2020

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Development and characterization of novel erythropoiesis stimulating protein (NESP)

31 March 2020

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Darbepoetin alfa has a longer circulating half-life and greater in vivo potency than recombinant human erythropoietin

31 March 2020

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Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria

31 March 2020

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31 March 2020

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Lectin affinity capture, isotope-coded tagging and mass spectrometry to identify N-linked glycoproteins.

31 March 2020

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Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry

31 March 2020

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Glycoprotein structure determination by mass spectrometry

31 March 2020

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Coupling capillary electrochromatography with electrospray Fourier transform mass spectrometry for characterizing complex oligosaccharide pools

31 March 2020

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Microanalysis of N-linked oligosaccharides in a glycoprotein by capillary liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry

31 March 2020

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Capillary electrophoresis/electrospray ion trap mass spectrometry for the analysis of negatively charged derivatized and underivatized glycans

31 March 2020

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Exploring the glycan repertoire of genetically modified mice by isolation and profiling of the major glycan classes and nano-NMR analysis of glycan mixtures

31 March 2020

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Sequencing complex polysaccharides

31 March 2020

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A novel computational approach to integrate NMR spectroscopy and capillary electrophoresis for structure assignment of heparin and heparan sulfate oligosaccharides.

31 March 2020

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Carbohydrate microarrays for the recognition of cross-reactive molecular markers of microbes and host cells

31 March 2020

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Oligosaccharide microarrays for high-throughput detection and specificity assignments of carbohydrate-protein interactions

31 March 2020

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Direct isolation and sequencing of specific protein-binding glycosaminoglycans

31 March 2020

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Intact cell adhesion to glycan microarrays

31 March 2020

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Synthesis of sugar arrays in microtiter plate

31 March 2020

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Automated solid-phase synthesis of oligosaccharides

31 March 2020

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A Programmable One‐Pot Oligosaccharide Synthesis for Diversifying the Sugar Domains of Natural Products: A Case Study of Vancomycin

31 March 2020

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A new strategy for the synthesis of glycoproteins.

31 March 2020

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Production of complex human glycoproteins in yeast

31 March 2020

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In vivo modulated N-acyl side chain of N-acetylneuraminic acid modulates the cell contact-dependent inhibition of growth

31 March 2020

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Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation

31 March 2020

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Expanding the diversity of unnatural cell-surface sialic acids

31 March 2020

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A chemical approach for identifying O-GlcNAc-modified proteins in cells

31 March 2020

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A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation

31 March 2020

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1976-1983, a critical period in the history of heparin: the discovery of the antithrombin binding site

31 March 2020

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Synthesis of thrombin-inhibiting heparin mimetics without side effects

31 March 2020

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Rational design of low-molecular weight heparins with improved in vivo activity

31 March 2020

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A role for 3-O-sulfated heparan sulfate in cell fusion induced by herpes simplex virus type 1.

31 March 2020

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31 March 2020

The heparins and cancer

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Heparan sulfate regulates amyloid precursor protein processing by BACE1, the Alzheimer's beta-secretase

31 March 2020

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Drug treatment of ulcerative colitis: unfractionated heparin, low molecular weight heparins and beyond

31 March 2020

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Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo.

31 March 2020

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Tumor cell surface heparan sulfate as cryptic promoters or inhibitors of tumor growth and metastasis

31 March 2020

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Dynamic regulation of tumor growth and metastasis by heparan sulfate glycosaminoglycans

31 March 2020

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Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas

31 March 2020

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Emerging views of heparan sulfate glycosaminoglycan structure/activity relationships modulating dynamic biological functions

31 March 2020

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Developing a taste for sweets

31 March 2020

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Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.

31 March 2020

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Chemical synthesis of normal and transformed PSA glycopeptides

31 March 2020

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Sequencing of 3-O sulfate containing heparin decasaccharides with a partial antithrombin III binding site

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1521

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11 August 2017

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