(Q35914963)

English

Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor.

scientific article published in January 2004

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scholarly article

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Europe PubMed Central

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4 January 2020

1 reference

Europe PubMed Central

Rethinking the role of Src family protein tyrosine kinases in the allergic response: new insights on the functional coupling of the high affinity IgE receptor (English)

1 reference

Europe PubMed Central

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4 January 2020

Martina Kovarova

4

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4 January 2020

author name string

Yasuko Furumoto

1

1 reference

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4 January 2020

Claudia Gonzalez-Espinosa

2

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4 January 2020

Gregorio Gomez

3

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4 January 2020

Sandra Odom

5

1 reference

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4 January 2020

Valentino Parravicini

6

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4 January 2020

John J Ryana

7

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4 January 2020

Juan Rivera

8

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4 January 2020

publication date

1 January 2004

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4 January 2020

Immunologic Research

1 reference

Europe PubMed Central

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4 January 2020

30

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4 January 2020

2

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4 January 2020

241-253

1 reference

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4 January 2020

https://scigraph.springernature.com/pub.10.1385/ir:30:2:241

0 references

One lyn molecule is sufficient to initiate phosphorylation of aggregated high-affinity IgE receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An absolute requirement for Fyn in T cell receptor-induced caspase activation and apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The four distal tyrosines are required for LAT-dependent signaling in FcepsilonRI-mediated mast cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmembrane adapters: attractants for cytoplasmic effectors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic ablation of the src kinase p59fynT exacerbates pulmonary inflammation in an allergic mouse model

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How do inositol phosphates regulate calcium signaling?

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential control of the tyrosine kinases Lyn and Syk by the two signaling chains of the high affinity immunoglobulin E receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dual fatty acylation of p59(Fyn) is required for association with the T cell receptor zeta chain through phosphotyrosine-Src homology domain-2 interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Preferential signaling and induction of allergy-promoting lymphokines upon weak stimulation of the high affinity IgE receptor on mast cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetic evidence for Lyn as a negative regulator of IL-4 signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and m

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

LAT is essential for Fc(epsilon)RI-mediated mast cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Compartmentalized activation of the high affinity immunoglobulin E receptor within membrane domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The simultaneous production of phosphatidic acid and diacylglycerol is essential for the translocation of protein kinase Cepsilon to the plasma membrane in RBL-2H3 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CSK: a protein-tyrosine kinase involved in regulation of src family kinases

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface IgM-stimulated proliferation, inositol phospholipid hydrolysis, Ca2+ flux, and tyrosine phosphorylation are not altered in B cells from p59fyn-1- mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A lipid raft environment enhances Lyn kinase activity by protecting the active site tyrosine from dephosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of NMDA receptor mediated synaptic plasticity using gene targeting: roles of Fyn and FAK non-receptor tyrosine kinases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and dephosphorylation of the high-affinity receptor for immunoglobulin E immediately after receptor engagement and disengagement

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function analysis of Lyn kinase association with lipid rafts and initiation of early signaling events after Fcepsilon receptor I aggregation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Overcoming the signaling defect of Lyn-sequestering, signal-curtailing FcepsilonRI dimers: aggregated dimers can dissociate from Lyn and form signaling complexes with Syk

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn tyrosine kinase participates in the compact myelin sheath formation in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

T cells expressing receptors of different affinity for antigen ligands reveal a unique role for p59fyn in T cell development and optimal stimulation of T cells by antigen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cutting edge: NKT cell development is selectively impaired in Fyn- deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Src family-selective tyrosine kinase inhibitor, PP1, inhibits both Fc epsilonRI- and Thy-1-mediated activation of rat basophilic leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Binding of SAP SH2 domain to FynT SH3 domain reveals a novel mechanism of receptor signalling in immune regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interaction between the unphosphorylated receptor with high affinity for IgE and Lyn kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fc epsilon RI-mediated recruitment of p53/56lyn to detergent-resistant membrane domains accompanies cellular signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Critical role for cholesterol in Lyn-mediated tyrosine phosphorylation of FcepsilonRI and their association with detergent-resistant membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transduction by the high-affinity immunoglobulin E receptor Fc epsilon RI: coupling form to function

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Requirement for negative charge on "activation loop" of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transmodulation between Phospholipase D and c-Src Enhances Cell Proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-affinity IgE receptor-mediated stimulation of rat basophilic leukemia (RBL-2H3) cells induces early and late protein-tyrosine phosphorylations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lyn dissociation from phosphorylated Fc epsilon RI subunits: a new regulatory step in the Fc epsilon RI signaling cascade revealed by studies of Fc epsilon RI dimer signaling activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The unique domain as the site on Lyn kinase for its constitutive association with the high affinity receptor for IgE

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aggregation of the high-affinity IgE receptor and enhanced activity of p53/56lyn protein-tyrosine kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

It's spring, and thoughts turn to...allergies

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fyn tyrosine kinase regulates oligodendroglial cell development but is not required for morphological differentiation of oligodendrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of fcepsilon receptor I-mediated activation of Syk

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential role for Gab2 in the allergic response

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of Src expression and activation in human cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/15477664

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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