(Q35925865)

11 August 2017

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title

The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors (English)

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11 August 2017

Anthony A Kossiakoff

1

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11 August 2017

publication date

1 January 2004

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Advances in Protein Chemistry

11 August 2017

published in

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11 August 2017

volume

68

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11 August 2017

page(s)

147-169

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Identification of JAK2 as a growth hormone receptor-associated tyrosine kinase

11 August 2017

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Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.

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Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity

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Zinc mediation of the binding of human growth hormone to the human prolactin receptor

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Engineering human prolactin to bind to the human growth hormone receptor

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Rational design of receptor-specific variants of human growth hormone

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Comparison of a structural and a functional epitope

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization

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Real-time kinetic measurements of the interactions between lactogenic hormones and prolactin-receptor extracellular domains from several species support the model of hormone-induced transient receptor dimerization

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Evaluating energetics of erythropoietin ligand binding to homodimerized receptor extracellular domains

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Ruminant placental lactogens act as antagonists to homologous growth hormone receptors and as agonists to human or rabbit growth hormone receptors

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Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors

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7 January 2021

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7 January 2021

The X-ray structure of a growth hormone-prolactin receptor complex

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7 January 2021

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

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7 January 2021

The crystal structure of affinity-matured human growth hormone at 2 A resolution

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7 January 2021

Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization

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7 January 2021

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7 January 2021

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7 January 2021

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

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7 January 2021

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7 January 2021

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Identifiers

DOI

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11 August 2017

1 reference