(Q35930506)

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The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition (English)

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Europe PubMed Central

PMC publication ID

11 August 2017

prostate cancer

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based on heuristic

inferred from title

Gaurav Choudhary

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026052%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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Payel Chatterjee

1

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12 June 2020

Turkeyah Alswillah

3

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12 June 2020

Xiahui Xiong

4

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12 June 2020

Warren D Heston

5

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12 June 2020

Cristina Magi-Galluzzi

6

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12 June 2020

Junran Zhang

7

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12 June 2020

Eric A Klein

8

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12 June 2020

Alexandru Almasan

9

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12 June 2020

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publication date

29 May 2015

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11 August 2017

Molecular Cancer Therapeutics

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12 June 2020

14

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12 June 2020

8

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12 June 2020

1896-1906

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12 June 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4529796/fullTextXML

based on heuristic

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Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Unraveling the complexities of DNA-dependent protein kinase autophosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

TMPRSS2:ERG gene fusion predicts subsequent detection of prostate cancer in patients with high-grade prostatic intraepithelial neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Targeted radiosensitization of ETS fusion-positive prostate cancer through PARP1 inhibition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

A hormone-DNA repair circuit governs the response to genotoxic insult

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Androgen receptor signaling regulates DNA repair in prostate cancers

1 reference

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2 October 2017

Defective chromatin recruitment and retention of NHEJ core components in human tumor cells expressing a Cyclin E fragment

1 reference

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2 October 2017

DNA double strand break repair via non-homologous end-joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

PARP inhibition sensitizes to low dose-rate radiation TMPRSS2-ERG fusion gene-expressing and PTEN-deficient prostate cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Overexpression of ETV4 is oncogenic in prostate cells through promotion of both cell proliferation and epithelial to mesenchymal transition

1 reference

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2 October 2017

A noncatalytic function of the ligation complex during nonhomologous end joining

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Homologous recombination repairs secondary replication induced DNA double-strand breaks after ionizing radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Discordance between phosphorylation and recruitment of 53BP1 in response to DNA double-strand breaks.

1 reference

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2 October 2017

A dual role of BRCA1 in two distinct homologous recombination mediated repair in response to replication arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Common gene rearrangements in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

The mTOR inhibitor rapamycin suppresses DNA double-strand break repair

1 reference

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2 October 2017

Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer

1 reference

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2 October 2017

Induced chromosomal proximity and gene fusions in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Ser1778 of 53BP1 Plays a Role in DNA Double-strand Break Repairs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Backup pathways of NHEJ in cells of higher eukaryotes: cell cycle dependence

1 reference

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2 October 2017

Enhancing radiosensitivity: targeting the DNA repair pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis

1 reference

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2 October 2017

Phospho-epitope binding by the BRCT domains of hPTIP controls multiple aspects of the cellular response to DNA damage

1 reference

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2 October 2017

An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

TMPRSS2 fusions with oncogenic ETS factors in prostate cancer involve unbalanced genomic rearrangements and are associated with HDAC1 and epigenetic reprogramming

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Role of non-homologous end joining (NHEJ) in maintaining genomic integrity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

2 October 2017

MDC1 interacts with Rad51 and facilitates homologous recombination

1 reference

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2 October 2017

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1 reference

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A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

1 reference

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DNA-dependent protein kinase and XRCC4-DNA ligase IV mobilization in the cell in response to DNA double strand breaks.

1 reference

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2 October 2017

XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

1 reference

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2 October 2017

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

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Molecular cytogenetics: Rosetta stone for understanding cancer--twenty-ninth G. H. A. Clowes memorial award lecture

1 reference

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2 October 2017

TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: implications for fusion status and DSB repair

1 reference

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24 September 2018

Statistical analysis of kinetics, distribution and co-localisation of DNA repair foci in irradiated cells: cell cycle effect and implications for prediction of radiosensitivity

1 reference

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24 September 2018

SnapShot: Nonhomologous DNA End Joining (NHEJ)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

24 September 2018

Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements

1 reference

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24 September 2018

Apoptosis induction in prostate cancer cells and xenografts by combined treatment with Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand and CPT-11.

1 reference

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24 September 2018

TMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With Invasion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4529796

14 November 2018

Chromosome Mechanisms Giving Rise to the TMPRSS2-ERG Fusion Oncogene in Prostate Cancer and HGPIN Lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/26026052

12 December 2020

based on heuristic

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10.1158/1535-7163.MCT-14-0865

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026052%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026052%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26026052%20AND%20SRC:MED&resulttype=core&format=json

12 June 2020

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