(Q35933720)

11 August 2017

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title

Prevention of type 2 diabetes mellitus through inhibition of the Renin-Angiotensin system (English)

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11 August 2017

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André J Scheen

1

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11 August 2017

publication date

1 January 2004

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11 August 2017

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11 August 2017

volume

64

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11 August 2017

issue

22

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11 August 2017

page(s)

2537-2565

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Management of hypertension in patients with type 2 diabetes mellitus: guidelines based on current evidence

11 August 2017

cites work

1 reference

12 December 2020

Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy. Heart Outcomes Prevention Evaluation Study Investigators

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12 December 2020

Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling

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12 December 2020

Screening adults for type 2 diabetes: a review of the evidence for the U.S. Preventive Services Task Force

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12 December 2020

A double blind comparison of the effects of amlodipine and enalapril on insulin sensitivity in hypertensive patients

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12 December 2020

Comparative effects of lisinopril and losartan on insulin sensitivity in the treatment of non diabetic hypertensive patients

1 reference

12 December 2020

Lisinopril administration improves insulin action in aged patients with hypertension.

1 reference

12 December 2020

Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension

1 reference

12 December 2020

The insertion/deletion polymorphism of the ACE gene is related to insulin sensitivity in overweight women

1 reference

12 December 2020

Insulin and the renin-angiotensin-aldosterone system: influence of ACE inhibition.

1 reference

12 December 2020

The alterations in insulin sensitivity during angiotensin converting enzyme inhibitor treatment are related to changes in the calcium/magnesium balance

1 reference

12 December 2020

ACE inhibition but not angiotensin II antagonism reduces plasma fibrinogen and insulin resistance in overweight hypertensive patients

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12 December 2020

Insulin resistance and cardiovascular disease

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12 December 2020

ACE inhibition improves insulin-sensitivity in aged insulin-resistant hypertensive patients

1 reference

12 December 2020

Diabetes mellitus. Report of a WHO Study Group

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12 December 2020

Angiotensin converting enzyme inhibitors and modulation of skeletal muscle insulin resistance

1 reference

12 December 2020

Cross-talk between the insulin and angiotensin signaling systems

1 reference

12 December 2020

Current management strategies for coexisting diabetes mellitus and obesity

1 reference

12 December 2020

Angiotensin mediates forearm glucose uptake by hemodynamic rather than direct effects

1 reference

12 December 2020

Insulin, insulin sensitivity and hypertension

1 reference

12 December 2020

Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients

1 reference

12 December 2020

Requirements for antihypertensive therapy in diabetic patients: metabolic aspects

1 reference

12 December 2020

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.

1 reference

12 December 2020

Improved glucose metabolism following blockade of angiotensin converting enzyme but not angiotensin AT1 receptors

1 reference

12 December 2020

Metabolic effects of long-term angiotensin-converting enzyme inhibition with fosinopril in patients with essential hypertension: relationship to angiotensin-converting enzyme inhibition

1 reference

12 December 2020

VALUE: analysis of results

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12 December 2020

Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

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12 December 2020

Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial

1 reference

12 December 2020

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes

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12 December 2020

Diabetes, hypertension, and cardiovascular disease: an update

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12 December 2020

The cost of diabetes Type II in Europe: the CODE-2 Study

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12 December 2020

Hypoglycaemia associated with use of inhibitors of angiotensin converting enzyme

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12 December 2020

Insulin sensitivity in patients with essential hypertension: no influence of the ACE inhibitor enalapril

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12 December 2020

The prevention or delay of type 2 diabetes

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12 December 2020

The mechanisms of insulin sensitivity improving effects of angiotensin converting enzyme inhibitor.

1 reference

12 December 2020

The Study on Cognition and Prognosis in the Elderly (SCOPE): principal results of a randomized double-blind intervention trial

1 reference

12 December 2020

Differential effects of ACE-inhibition and angiotensin II antagonism on fibrinolysis and insulin sensitivity in hypertensive postmenopausal women

1 reference

12 December 2020

Renin-angiotensin system gene polymorphisms, blood pressure, dyslipidemia, and diabetes in Hong Kong Chinese: a significant association of tne ACE insertion/deletion polymorphism with type 2 diabetes.

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12 December 2020

The role of the angiotensin system in cardiac glucose homeostasis: therapeutic implications

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12 December 2020

Effects of trandolapril and verapamil on glucose transport in insulin-resistant rat skeletal muscle

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12 December 2020

Potentiation of Bradykinin Actions by ACE Inhibitors

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12 December 2020

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

1 reference

12 December 2020

Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension

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12 December 2020

Effects of combination therapy with an angiotensin converting enzyme inhibitor and thiazide diuretic on insulin action in essential hypertension

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12 December 2020

Association of angiotensin converting enzyme and plasminogen activator inhibitor-1 promoter gene polymorphisms with features of the insulin resistance syndrome in patients with premature coronary heart disease

1 reference

12 December 2020

The effect of angiotensin II receptor antagonism with losartan on glucose metabolism and insulin sensitivity

1 reference

12 December 2020

How to measure insulin action in vivo

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12 December 2020

Prevention of diabetes mellitus. Report of a WHO Study Group

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12 December 2020

Pharmacologic approaches to the prevention of type 2 diabetes in high risk pediatric patients

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12 December 2020

Cardiovascular morbidity and mortality in the Losartan Intervention For Endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol

1 reference

12 December 2020

Opposing effects of angiotensin II on muscle and renal blood flow under euglycemic conditions.

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12 December 2020

Association of the ACE gene I/D polymorphism with insulin sensitivity depends on the presence of additional macroangiopathic risk factors

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12 December 2020

Losartan mediated improvement in insulin action is mainly due to an increase in non-oxidative glucose metabolism and blood flow in insulin-resistant hypertensive patients

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12 December 2020

Prevention of the Glucose Intolerance of Thiazide Diuretics by Maintenance of Body Potassium

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12 December 2020

Induction of insulin resistance by beta-blockade but not ACE-inhibition: long-term treatment with atenolol or trandolapril.

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12 December 2020

Risk factors for developing non-insulin dependent diabetes: a 10 year follow up of men in Uppsala

1 reference

12 December 2020

Insertion/deletion polymorphism of the ACE gene is associated with type 2 diabetes

1 reference

12 December 2020

Rationale, design, and baseline characteristics of 2 large, simple, randomized trials evaluating telmisartan, ramipril, and their combination in high-risk patients: the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial

1 reference

12 December 2020

Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia

1 reference

12 December 2020

Reduction of cardiovascular events and microvascular complications in diabetes with ACE inhibitor treatment: HOPE and MICRO-HOPE.

1 reference

12 December 2020

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12 December 2020

Orlistat: in the prevention and treatment of type 2 diabetes mellitus

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12 December 2020

The insulin sensitivity concept

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12 December 2020

Angiotensin type 1 receptor blockers induce peroxisome proliferator-activated receptor-gamma activity

1 reference

12 December 2020

The link between insulin resistance and hypertension. Effects of antihypertensive and antihyperlipidaemic drugs on insulin sensitivity

1 reference

12 December 2020

Health outcomes associated with antihypertensive therapies used as first-line agents. A systematic review and meta-analysis

1 reference

12 December 2020

Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)

1 reference

12 December 2020

Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections

1 reference

12 December 2020

Angiotensin II induces insulin resistance independent of changes in interstitial insulin

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12 December 2020

Modulation of metabolic control by angiotensin converting enzyme (ACE) inhibition

1 reference

12 December 2020

Angiotensin-Converting Enzyme Inhibitors and Insulin Sensitivity: Metabolic Effects in Hypertension, Diabetes, and Heart Failure

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12 December 2020

Microalbuminuria precedes the development of NIDDM

1 reference

12 December 2020

A comparison of the hypotensive and hypoglycaemic actions of an angiotensin converting enzyme inhibitor, an AT1a antagonist and troglitazone

1 reference

12 December 2020

Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus. Atherosclerosis Risk in Communities Study

1 reference

12 December 2020

The effects of valsartan on insulin sensitivity in patients with primary hypertension

1 reference

12 December 2020

Preservation of pancreatic beta-cell function and prevention of type 2 diabetes by pharmacological treatment of insulin resistance in high-risk hispanic women

1 reference

12 December 2020

Metabolic outcome during 1 year in newly detected hypertensives: results of the Antihypertensive Treatment and Lipid Profile in a North of Sweden Efficacy Evaluation (ALPINE study).

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12 December 2020

Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with hypertension

1 reference

12 December 2020

Effects of the angiotensin converting enzyme inhibitor temocapril on insulin sensitivity and its effects on renal sodium handling and the pressor system in essential hypertensive patients

1 reference

12 December 2020

Angiotensin II Affects Basal, Pulsatile, and Glucose-Stimulated Insulin Secretion in Humans

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12 December 2020

Insulin resistance and hypertension

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12 December 2020

XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients

1 reference

12 December 2020

Angiotensinogen gene polymorphism is associated with insulin resistance in nondiabetic men with or without coronary heart disease

1 reference

12 December 2020

Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and diabetes project

1 reference

12 December 2020

Effect of captopril on glucose concentration. Possible role of augmented postprandial forearm blood flow.

1 reference

12 December 2020

Health care and health status and outcomes for patients with type 2 diabetes

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12 December 2020

Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes

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12 December 2020

ACE inhibitor use is associated with hospitalization for severe hypoglycemia in patients with diabetes. DARTS/MEMO Collaboration. Diabetes Audit and Research in Tayside, Scotland. Medicines Monitoring Unit

1 reference

12 December 2020

Effects of candesartan on mortality and morbidity in patients with chronic heart failure: the CHARM-Overall programme

1 reference

12 December 2020

Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus

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12 December 2020

Risk of new-onset diabetes in the Losartan Intervention For Endpoint reduction in hypertension study

1 reference

12 December 2020

The I/D polymorphism of angiotensin-converting enzyme gene but not the angiotensinogen gene is associated with insulin response to oral glucose in Japanese

1 reference

12 December 2020

Tissue renin-angiotensin system: its expression, localization, regulation and potential role in the pancreas

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12 December 2020

Effect on insulin sensitivity of angiotensin converting enzyme inhibitors with or without a sulphydryl group: bradykinin may improve insulin resistance in dogs and humans

1 reference

12 December 2020

Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease

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12 December 2020

Vascular defects in the aetiology of peripheral insulin resistance in diabetes. A critical review of hypotheses and facts

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12 December 2020

Insulin-resistant lipolysis in abdominally obese hypertensive individuals. Role of the renin-angiotensin system

1 reference

12 December 2020

The insertion allele of the ACE gene I/D polymorphism. A candidate gene for insulin resistance?

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12 December 2020

Relationship between angiotensin-converting enzyme gene polymorphism and insulin resistance in never-treated hypertensive patients

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12 December 2020

A new dimension in hypertension: role of insulin resistance

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12 December 2020

Treatment of Mild Hypertension Study. Final results. Treatment of Mild Hypertension Study Research Group

1 reference

12 December 2020

Angiotensin blockade prevents type 2 diabetes by formation of fat cells

1 reference

12 December 2020

Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension

1 reference

12 December 2020

Insulin resistance and hyperinsulinemia in patients with chronic congestive heart failure

1 reference

12 December 2020

Effects of losartan on insulin sensitivity in hypertensive subjects

1 reference

12 December 2020

Improved insulin action and glycemic control after long-term angiotensin-converting enzyme inhibition in subjects with arterial hypertension and type II diabetes

1 reference

12 December 2020

A comparison of the effects of hydrochlorothiazide and captopril on glucose and lipid metabolism in patients with hypertension

1 reference

12 December 2020

ACE gene insertion/deletion polymorphism associated with 1998 World Health Organization definition of metabolic syndrome in Chinese type 2 diabetic patients

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12 December 2020

Crosstalk between insulin and angiotensin II signalling systems

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12 December 2020

Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial

1 reference

12 December 2020

Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system

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12 December 2020

The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations.

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12 December 2020

Electrolyte changes and metabolic effects of lisinopril/bendrofluazide treatment. Results from a randomized, double-blind study with parallel groups

1 reference

12 December 2020

Angiotensin-converting enzyme (ACE) inhibition. Therapeutic option for diabetic hypertensive patients

1 reference

12 December 2020

Interactions of captopril and verapamil on glucose tolerance and insulin action in an animal model of insulin resistance

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12 December 2020

ACE-inhibition increases hepatic and extrahepatic sensitivity to insulin in patients with type 2 (non-insulin-dependent) diabetes mellitus and arterial hypertension

1 reference

12 December 2020

Insulin sensitivity in obese hypertensive dyslipidemic patients treated with enalapril or atenolol

1 reference

12 December 2020

Angiotensin-1—converting enzyme (ACE) gene polymorphism, plasma ACE levels, and their association with the metabolic syndrome and electrocardiographic coronary artery disease in Pima Indians

1 reference

12 December 2020

The effect of angiotensin II receptor blockade on insulin sensitivity and sympathetic nervous system activity in primary hypertension.

1 reference

12 December 2020

Improved insulin response and action by chronic magnesium administration in aged NIDDM subjects

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12 December 2020

Effect of angiotensin converting enzyme inhibitor (lisinopril) on insulin sensitivity and sodium transport in mild hypertension.

1 reference

12 December 2020

Hypertension in Diabetes Study (HDS): I. Prevalence of hypertension in newly presenting type 2 diabetic patients and the association with risk factors for cardiovascular and diabetic complications

1 reference

12 December 2020

Genetic variability in the renin-angiotensin system: prevalence of alleles and genotypes

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12 December 2020

Effect of experimental potassium deficiency on glucose and insulin metabolism

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12 December 2020

Identification of telmisartan as a unique angiotensin II receptor antagonist with selective PPARgamma-modulating activity

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12 December 2020

Effects of Antihypertensive Treatment on Insulin Sensitivity With Special Reference to ACE Inhibitors

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12 December 2020

Deletion polymorphism in the gene for angiotensin converting enzyme is associated with elevated fasting blood glucose levels

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12 December 2020

Ramipril and the development of diabetes.

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12 December 2020

Effect of Captopril, Losartan, and Bradykinin on Early Steps of Insulin Action

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12 December 2020

Hypertension, the Potassium Ion and Impaired Carbohydrate Tolerance

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12 December 2020

Trandolapril does not improve insulin sensitivity in patients with hypertension and type 2 diabetes: a double-blind, placebo-controlled crossover trial

1 reference

12 December 2020

Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance

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12 December 2020

Antihypertensive drug therapy and the initiation of treatment for diabetes mellitus

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12 December 2020

Hyperinsulinemia and elevated blood pressure: cause, confounder, or coincidence?

1 reference

12 December 2020

Magnesium and glucose homeostasis

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12 December 2020

Management of type 2 diabetes mellitus and cardiovascular risk: lessons from intervention trials

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12 December 2020

Enalapril reduces the incidence of diabetes in patients with chronic heart failure: insight from the Studies Of Left Ventricular Dysfunction (SOLVD).

1 reference

12 December 2020

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance

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12 December 2020

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels

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12 December 2020

Pathophysiological implications of insulin resistance on vascular endothelial function.

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12 December 2020

Circulating catecholamines and metabolic effects of captopril in NIDDM patients

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12 December 2020

Adiponectin: more than just another fat cell hormone?

1 reference

12 December 2020

Quinapril treatment enhances vascular sensitivity to insulin

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12 December 2020

CAPPP trial. Captopril Prevention Project

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12 December 2020

Effects of inhibition of the renin-angiotensin system on the cardiovascular actions of insulin

1 reference

12 December 2020

Potential role of bradykinin in forearm muscle metabolism in humans

1 reference

12 December 2020

The insertion allele at the angiotensin I-converting enzyme gene locus is associated with insulin resistance

1 reference

12 December 2020

A possible link between endothelial dysfunction and insulin resistance in hypertension. A LIFE substudy. Losartan Intervention For Endpoint-Reduction in Hypertension.

1 reference

12 December 2020

Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy

1 reference

12 December 2020

ACE inhibition and glucose transport in insulinresistant muscle: roles of bradykinin and nitric oxide.

1 reference

12 December 2020

Modulation of insulin receptor signaling. Potential mechanisms of a cross talk between bradykinin and the insulin receptor

1 reference

12 December 2020

Relationship of the angiotensin-converting enzyme gene polymorphism to glucose intolerance, insulin resistance, and hypertension in NIDDM.

1 reference

12 December 2020

Imidapril, an angiotensin-converting enzyme inhibitor, improves insulin sensitivity by enhancing signal transduction via insulin receptor substrate proteins and improving vascular resistance in the Zucker fatty rat.

1 reference

12 December 2020

Effects of calcium antagonists on glucose homeostasis and serum lipids in non-diabetic and diabetic subjects: a review.

1 reference

12 December 2020

Insulin resistance in essential hypertension

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12 December 2020

Role of the B(2) receptor of bradykinin in insulin sensitivity

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12 December 2020

Effect of bradykinin-receptor blockade on the response to angiotensin-converting-enzyme inhibitor in normotensive and hypertensive subjects.

1 reference

12 December 2020

Angiotensin II and the endocrine pancreas: effects on islet blood flow and insulin secretion in rats

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12 December 2020

Captopril and insulin sensitivity

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12 December 2020

Antihypertensive therapy and the risk of type 2 diabetes mellitus

1 reference

12 December 2020

Association between antihypertensive drug use and hypoglycemia: a case-control study of diabetic users of insulin or sulfonylureas

1 reference

12 December 2020

Regression of left ventricular mass with captopril and metoprolol, and the effects on glucose and lipid metabolism

1 reference

12 December 2020

Skeletal muscle blood flow. A possible link between insulin resistance and blood pressure.

1 reference

12 December 2020

PPAR(gamma) and glucose homeostasis

1 reference

12 December 2020

Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

1 reference

12 December 2020

Insulin-sensitizing effects of telmisartan: implications for treating insulin-resistant hypertension and cardiovascular disease

1 reference

12 December 2020

Effects of angiotensin-converting enzyme inhibitors on glucose and lipid metabolism in essential hypertension

1 reference

12 December 2020

Incidence of NIDDM and impaired glucose tolerance in hypertensive subjects. The San Antonio Heart Study

1 reference

12 December 2020

Kinins contribute to the improvement of insulin sensitivity during treatment with angiotensin converting enzyme inhibitor

1 reference

12 December 2020

From the HOPE to the ONTARGET and the TRANSCEND studies: challenges in improving prognosis

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12 December 2020

Controlled study of the effect of angiotensin converting enzyme inhibition versus calcium-entry blockade on insulin sensitivity in overweight hypertensive patients

1 reference

12 December 2020

Genetic variation in the renin-angiotensin system and abdominal adiposity in men: the Olivetti Prospective Heart Study

1 reference

12 December 2020

Improving the action of insulin.

1 reference

12 December 2020

Banting lecture 1988. Role of insulin resistance in human disease

1 reference

12 December 2020

Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation

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12 December 2020

The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure<SUBTITLE>The JNC 7 Report</SUBTITLE>

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12 December 2020

The role of angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists in the management of diabetic complications

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12 December 2020

Do antihypertensive drugs precipitate diabetes?

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12 December 2020

The hemodynamic link between insulin resistance and hypertension

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12 December 2020

Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension

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12 December 2020

Antihypertensive therapy and incidence of type 2 diabetes: a systematic review

1 reference

12 December 2020

Is There a Role for ??-Glucosidase Inhibitors in the Prevention of Type 2 Diabetes Mellitus?

1 reference

12 December 2020

Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration

1 reference

12 December 2020

Clinical review 79: Angiotensin II: an insulin-sensitizing vasoactive hormone?

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12 December 2020

Physiology and pathophysiology of the adipose tissue renin-angiotensin system

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12 December 2020

Angiotensin I converting enzyme gene polymorphism and insulin resistance in patients with angina pectoris

1 reference

12 December 2020

Effects of chronic angiotensin converting enzyme inhibition on glucose tolerance and insulin sensitivity in essential hypertension

1 reference

12 December 2020

Major Factors in the Development of Diabetes Mellitus in 10,000 Men

1 reference

12 December 2020

Effect of an angiotensin II receptor antagonist, candesartan, on insulin resistance and pressor mechanisms in essential hypertension.

1 reference

12 December 2020

Inhibition of angiotensin type 1 receptor prevents decline of glucose transporter (GLUT4) in diabetic rat heart

1 reference

12 December 2020

Randomised trial of old and new antihypertensive drugs in elderly patients: cardiovascular mortality and morbidity the Swedish Trial in Old Patients with Hypertension-2 study

1 reference

12 December 2020

Metabolic effects of doxazosin and enalapril in hypertriglyceridemic, hypertensive men. Relationship to changes in skeletal muscle blood flow

1 reference

12 December 2020

The effects of ramipril on glucose tolerance, insulin secretion, and insulin sensitivity in patients with hypertension

1 reference

12 December 2020

The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group

1 reference

12 December 2020

Captopril does not improve insulin action in essential hypertension: a double-blind placebo-controlled study

1 reference

12 December 2020

10.2165/00003495-200464220-00004

Identifiers

DOI

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Dimensions Publication ID

11 August 2017

1038240510

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