(Q35936444)

11 August 2017

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title

Stopping clinical trials by design (English)

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11 August 2017

John Whitehead

1

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11 August 2017

1 November 2004

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Nature Reviews Drug Discovery

11 August 2017

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11 August 2017

3

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11 August 2017

11

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11 August 2017

973-977

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https://scigraph.springernature.com/pub.10.1038/nrd1553

11 August 2017

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Are large clinical trials in rapidly lethal diseases usually unethical?

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A randomized trial of letrozole in postmenopausal women after five years of tamoxifen therapy for early-stage breast cancer

21 January 2018

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21 January 2018

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21 January 2018

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Mid-course sample size modification in clinical trials based on the observed treatment effect

21 January 2018

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An adaptive approach to implementing bivariate group sequential clinical trial designs

21 January 2018

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Design and analysis of group sequential clinical trials with multiple primary endpoints

21 January 2018

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Issues in designing flexible trials

21 January 2018

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A method for sequential analysis of survival data with nonproportional hazards

21 January 2018

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Quality of health care delivered to adults in the United States

31 March 2020

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Formal approaches to safety monitoring of clinical trials in life-threatening conditions

31 March 2020

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Stopping clinical trials because of treatment ineffectiveness: a comparison of a futility design with a method of stochastic curtailment

31 March 2020

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A Multiple Testing Procedure for Clinical Trials

31 March 2020

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Exact confidence intervals following a group sequential test

31 March 2020

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Sample size re-estimation without unblinding for normally distributed outcomes with unknown variance

31 March 2020

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Planning and revising the sample size for a trial

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD1553

1 reference

PubMed ID

15520819

Dimensions Publication ID

11 August 2017

0 references

1 reference

PubMed ID

15520819