(Q35952687)

11 August 2017

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title

Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation (English)

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11 August 2017

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Dorne JL

1

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11 August 2017

publication date

1 December 2004

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Fundamental and Clinical Pharmacology

11 August 2017

published in

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11 August 2017

volume

18

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11 August 2017

issue

6

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11 August 2017

page(s)

609-620

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The concept of the acceptable daily intake: an historical review

11 August 2017

cites work

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https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Safety factors and establishment of acceptable daily intakes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Data-derived safety factors for the evaluation of food additives and environmental contaminants

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Evolution of science-based uncertainty factors in noncancer risk assessment

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Species-specific uncertainty factors for compounds eliminated principally by renal excretion in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Identification and functional characterization of eight CYP3A4 protein variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

The influence of posture on the pharmacokinetics of orally administered nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

The CYP2C19 enzyme polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Factors affecting the absolute bioavailability of nifedipine

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Developmental expression of human hepatic CYP2C9 and CYP2C19.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1472-8206.2004.00292.X

10.1111/J.1472-8206.2004.00292.X

21 January 2018

Identifiers

DOI

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11 August 2017

1 reference