(Q35955151)

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1 February 2020

2 references

8 February 2021

17 October 2022

Programmed death ligand 2 in cancer-induced immune suppression (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

19 September 2019

programmed cell death 1 ligand 2

1 reference

15 December 2019

1 reference

8 February 2021

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

author name string

Esdy N Rozali

1

1 reference

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1 February 2020

Stanleyson V Hato

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Bruce W Robinson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

Richard A Lake

4

1 reference

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1 February 2020

publication date

29 April 2012

7 references

3 April 2019

25 June 2019

19 September 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

8 February 2021

17 October 2022

Clinical and Developmental Immunology

7 references

3 April 2019

25 June 2019

19 September 2019

15 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

8 February 2021

17 October 2022

2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

page(s)

656340

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 3.0 Unported

1 February 2020

copyright license

6 references

3 April 2019

25 June 2019

19 September 2019

15 December 2019

8 February 2021

on focus list of Wikimedia project

17 October 2022

copyright status

copyrighted

0 references

ScienceSource

0 references

cites work

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2 October 2017

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Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice

2 October 2017

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Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

2 October 2017

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Thymic stromal lymphopoietin fosters human breast tumor growth by promoting type 2 inflammation

2 October 2017

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The role of the PD-1 pathway in autoimmunity and peripheral tolerance

2 October 2017

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2 October 2017

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Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates

2 October 2017

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Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma

2 October 2017

1 reference

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PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

2 October 2017

1 reference

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Distinct signal codes generate dendritic cell functional plasticity

2 October 2017

1 reference

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Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis

2 October 2017

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PD-L1 and PD-L2 modulate airway inflammation and iNKT-cell-dependent airway hyperreactivity in opposing directions

2 October 2017

1 reference

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Blockade of B7-H1 or B7-DC induces an anti-tumor effect in a mouse pancreatic cancer model.

2 October 2017

1 reference

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PD-1 signaling in primary T cells

2 October 2017

1 reference

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Yin-Yang of costimulation: crucial controls of immune tolerance and function

2 October 2017

1 reference

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PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

2 October 2017

1 reference

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PD-1/PD-L blockade prevents anergy induction and enhances the anti-tumor activities of glycolipid-activated invariant NKT cells

2 October 2017

1 reference

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Overexpression of PD-L1 significantly associates with tumor aggressiveness and postoperative recurrence in human hepatocellular carcinoma

2 October 2017

1 reference

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Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2

2 October 2017

1 reference

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Inhibitory B7-family molecules in the tumour microenvironment

2 October 2017

1 reference

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The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors

2 October 2017

1 reference

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PD-1 and its ligands in tolerance and immunity

2 October 2017

1 reference

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Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses

2 October 2017

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PD-1 and PD-1 ligands: from discovery to clinical application

2 October 2017

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Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development

2 October 2017

1 reference

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Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer

2 October 2017

1 reference

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Regulation of T cell activation and tolerance by PDL2

2 October 2017

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T-cell tolerance or function is determined by combinatorial costimulatory signals

2 October 2017

1 reference

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Tissue expression of PD-L1 mediates peripheral T cell tolerance.

2 October 2017

1 reference

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No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation

2 October 2017

1 reference

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Tumor B7-H1 is associated with poor prognosis in renal cell carcinoma patients with long-term follow-up.

2 October 2017

1 reference

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Signaling mechanisms, interaction partners, and target genes of STAT6.

2 October 2017

1 reference

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CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Blocking programmed death-1 ligand-PD-1 interactions by local gene therapy results in enhancement of antitumor effect of secondary lymphoid tissue chemokine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

SHP-1 and SHP-2 associate with immunoreceptor tyrosine-based switch motif of programmed death 1 upon primary human T cell stimulation, but only receptor ligation prevents T cell activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Differential binding properties of B7-H1 and B7-DC to programmed death-1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Expression of programmed death 1 ligands by murine T cells and APC

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

STATing the importance of immune modulation by platinum chemotherapeutics

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Tissue-based class control: the other side of tolerance.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

The common gamma-chain cytokines IL-2, IL-7, IL-15, and IL-21 induce the expression of programmed death-1 and its ligands

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

PD-1 ligand expression by human colonic myofibroblasts/fibroblasts regulates CD4+ T-cell activity

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

PD-L2 expression extends beyond dendritic cells/macrophages to B1 cells enriched for V(H)11/V(H)12 and phosphatidylcholine binding.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Expression of programmed death-1 ligand (PD-L) 1, PD-L2, B7-H3, and inducible costimulator ligand on human respiratory tract epithelial cells and regulation by respiratory syncytial virus and type 1 and 2 cytokines

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Blockade of B7-H1 Suppresses the Development of Chronic Intestinal Inflammation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3350956

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

24 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2012%2F656340

Differential role of programmed death-ligand 1 [corrected] and programmed death-ligand 2 [corrected] in regulating the susceptibility and chronic progression of experimental autoimmune encephalomyelitis

21 January 2018

1 reference

12 December 2020

Alternatively activated macrophages inhibit T-cell proliferation by Stat6-dependent expression of PD-L2

1 reference

12 December 2020

A critical role for NF-kappa B in GATA3 expression and TH2 differentiation in allergic airway inflammation

1 reference

12 December 2020

PD-L2 is expressed on activated human T cells and regulates their function

1 reference

12 December 2020

Deal watch: GlaxoSmithKline and Amplimmune join forces on targeting PD1

1 reference

12 December 2020

IL-4-stimulated NF-kappaB activity is required for Stat6 DNA binding

1 reference

12 December 2020

PD-L2 is predominantly expressed by Th2 cells

1 reference

12 December 2020

A novel role for interleukin-27 (IL-27) as mediator of intestinal epithelial barrier protection mediated via differential signal transducer and activator of transcription (STAT) protein signaling and induction of antibacterial and anti-inflammatory

1 reference

12 December 2020

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

1 reference

12 December 2020

Immunotherapy and chemotherapy--a practical partnership

1 reference

12 December 2020

Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/656340

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

PubMed publication ID

22611421

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611421%20AND%20SRC:MED&resulttype=core&format=json