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Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
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scholarly article
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stated in
Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
title
Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
author
Matthias Dobbelstein
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
author name string
Priyanka Saini
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
Yizhu Li
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
language of work or name
English
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publication date
1 May 2015
1 reference
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Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
published in
Oncotarget
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
issue
15
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
page(s)
13072-13087
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
cites work
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Wee1 kinase as a target for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation of Cdc5 regulates its accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Targeting cancer with small molecule kinase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Human CtIP promotes DNA end resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Cdc28-dependent regulation of the Cdc5/Polo kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Characterization of mutations and loss of heterozygosity of p53 and K-ras2 in pancreatic cancer cell lines by immobilized polymerase chain reaction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
p21/CDKN1A mediates negative regulation of transcription by p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25965828
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/ONCOTARGET.3865
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
PMC publication ID
4537000
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
PubMed publication ID
25965828
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
ResearchGate publication ID
276208523
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