Home
Random
Nearby
Log in
Settings
Donate
About Wikidata
Disclaimers
Search
(Q35955216)
Watch
English
Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
scientific article
In more languages
default for all languages
No label defined
No description defined
edit
Statements
instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
title
Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
author
Matthias Dobbelstein
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
author name string
Priyanka Saini
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
Yizhu Li
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
language of work or name
English
0 references
publication date
1 May 2015
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
retrieved
11 August 2017
published in
Oncotarget
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
volume
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
issue
15
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
page(s)
13072-13087
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
cites work
Combined inhibition of Wee1 and PARP1/2 for radiosensitization in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Wee1 kinase as a target for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Unique functions of CHK1 and WEE1 underlie synergistic anti-tumor activity upon pharmacologic inhibition
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The p38/MK2-driven exchange between tristetraprolin and HuR regulates AU-rich element-dependent translation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The novel ATR inhibitor VE-821 increases sensitivity of pancreatic cancer cells to radiation and chemotherapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Forced mitotic entry of S-phase cells as a therapeutic strategy induced by inhibition of WEE1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation of Cdc5 regulates its accumulation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Chk1 inhibition and Wee1 inhibition combine synergistically to impede cellular proliferation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Thr-1989 phosphorylation is a marker of active ataxia telangiectasia-mutated and Rad3-related (ATR) kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
MK-1775, a potent Wee1 inhibitor, synergizes with gemcitabine to achieve tumor regressions, selectively in p53-deficient pancreatic cancer xenografts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Synthetic lethal RNAi screening identifies sensitizing targets for gemcitabine therapy in pancreatic cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Targeting cancer with small molecule kinase inhibitors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
DNA damage detection and repair pathways--recent advances with inhibitors of checkpoint kinases in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Human CtIP promotes DNA end resection
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Polo-like kinase-1 controls proteasome-dependent degradation of Claspin during checkpoint recovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
SCFbetaTrCP-mediated degradation of Claspin regulates recovery from the DNA replication checkpoint response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Destruction of Claspin by SCFbetaTrCP restrains Chk1 activation and facilitates recovery from genotoxic stress
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Cdc28-dependent regulation of the Cdc5/Polo kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phosphorylation by Cdk1 induces Plk1-mediated vimentin phosphorylation during mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Characterization of mutations and loss of heterozygosity of p53 and K-ras2 in pancreatic cancer cell lines by immobilized polymerase chain reaction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
p21/CDKN1A mediates negative regulation of transcription by p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Activation of mammalian Chk1 during DNA replication arrest: a role for Chk1 in the intra-S phase checkpoint monitoring replication origin firing
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Degradation of the retinoblastoma tumor suppressor by the human papillomavirus type 16 E7 oncoprotein is important for functional inactivation and is separable from proteasomal degradation of E7.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Gemcitabine and cisplatin versus methotrexate, vinblastine, doxorubicin, and cisplatin in advanced or metastatic bladder cancer: results of a large, randomized, multinational, multicenter, phase III study
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Phase III trial of gemcitabine plus cisplatin versus cisplatin alone in patients with locally advanced or metastatic non-small-cell lung cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: a randomized trial
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Chk1 is a wee1 kinase in the G2 DNA damage checkpoint inhibiting cdc2 by Y15 phosphorylation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
2 October 2017
Forced activation of Cdk1 via wee1 inhibition impairs homologous recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Gemcitabine plus Paclitaxel versus Paclitaxel monotherapy in patients with metastatic breast cancer and prior anthracycline treatment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Comparison of gemcitabine versus the matrix metalloproteinase inhibitor BAY 12-9566 in patients with advanced or metastatic adenocarcinoma of the pancreas: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4537000
retrieved
24 September 2018
Specific protein dephosphorylation in apoptosis induced by ionizing radiation and heat shock in human lymphoid tumor lines
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25965828
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.18632/ONCOTARGET.3865
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
PMC publication ID
4537000
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
PubMed publication ID
25965828
1 reference
stated in
Europe PubMed Central
PMC publication ID
4537000
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25965828%20AND%20SRC:MED&resulttype=core&format=json
retrieved
11 June 2020
ResearchGate publication ID
276208523
0 references
Sitelinks
Wikipedia
(0 entries)
edit
Wikibooks
(0 entries)
edit
Wikinews
(0 entries)
edit
Wikiquote
(0 entries)
edit
Wikisource
(0 entries)
edit
Wikiversity
(0 entries)
edit
Wikivoyage
(0 entries)
edit
Wiktionary
(0 entries)
edit
Multilingual sites
(0 entries)
edit
