(Q36000046)

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Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines.

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scholarly article

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1 March 2020

Elevated Ca2+ transients and increased myofibrillar power generation cause cardiac hypercontractility in a model of Noonan syndrome with multiple lentigines (English)

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25724491%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

Noonan syndrome

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Timothy L. Domeier

2

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1 March 2020

Kerry S. McDonald

4

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1 March 2020

author name string

Sarah A Clay

1

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1 March 2020

Laurin M Hanft

3

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1 March 2020

Maike Krenz

5

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1 March 2020

publication date

27 February 2015

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1 March 2020

American Journal of Physiology Heart and Circulatory Physiology

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1 March 2020

308

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1 March 2020

9

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1 March 2020

H1086-95

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1 March 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4551123/fullTextXML

based on heuristic

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LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity

1 reference

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2 October 2017

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Length and PKA Dependence of Force Generation and Loaded Shortening in Porcine Cardiac Myocytes

1 reference

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SHP-2 acts via ROCK to regulate the cardiac actin cytoskeleton

1 reference

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Mechanisms of disease: hypertrophic cardiomyopathy

1 reference

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2 October 2017

LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3β/β-catenin signaling

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2 October 2017

Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation.

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2 October 2017

Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum

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Prevalence and clinical significance of cardiovascular abnormalities in patients with the LEOPARD syndrome.

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2 October 2017

Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy

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Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes

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Adenoviral gene transfer of Akt enhances myocardial contractility and intracellular calcium handling.

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Dynamics of Z-band based proteins in developing skeletal muscle cells

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2 October 2017

Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4551123

2 October 2017

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

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2 October 2017

Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4551123

2 October 2017

Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4551123

2 October 2017

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2 October 2017

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation

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Hypertrophic cardiomyopathy. Clinical spectrum and treatment.

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Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults

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LEOPARD Syndrome: Clinical Features and Gene Mutations

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Left ventricular twist mechanics in hypertrophic cardiomyopathy assessed by three-dimensional speckle tracking echocardiography.

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23 September 2018

Novel BRAF mutation in a patient with LEOPARD syndrome and normal intelligence

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A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy

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Genotype–phenotype analysis and natural history of left ventricular hypertrophy in LEOPARD syndrome

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25724491

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25724491

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1 reference

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based on heuristic

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The purification of cardiac myofibrils with Triton X-100

1 reference

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12 December 2020

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The pathogenesis of familial hypertrophic cardiomyopathy: early and evolving effects from an alpha-cardiac myosin heavy chain missense mutation

1 reference

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Cardiac myocyte calcium transport in phospholamban knockout mouse: relaxation and endogenous CaMKII effects

1 reference

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based on heuristic

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Ca2+ dependence of loaded shortening in rat skinned cardiac myocytes and skeletal muscle fibres

1 reference

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Computer programs for calculating total from specified free or free from specified total ionic concentrations in aqueous solutions containing multiple metals and ligands

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Power output is increased after phosphorylation of myofibrillar proteins in rat skinned cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25724491

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inorganic phosphate speeds loaded shortening in rat skinned cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/25724491

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transgenic remodeling of the contractile apparatus in the mammalian heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/25724491

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1152/AJPHEART.00501.2014

1 reference

Europe PubMed Central

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1 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25724491%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25724491%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

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