(Q36028191)

11 August 2017

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title

Roles of interferon-regulatory factors in T-helper-cell differentiation (English)

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11 August 2017

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Michael Lohoff

1

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PubMed ID

15688040

11 August 2017

Tak W Mak

series ordinal

2

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11 August 2017

1 February 2005

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Nature Reviews Immunology

11 August 2017

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11 August 2017

5

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11 August 2017

125-135

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11 August 2017

2

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Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements

11 August 2017

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21 January 2018

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Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system

21 January 2018

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Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

21 January 2018

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Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes

21 January 2018

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Virus-specific activation of a novel interferon regulatory factor, IRF-5, results in the induction of distinct interferon alpha genes

21 January 2018

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An interferon gamma-regulated protein that binds the interferon-inducible enhancer element of major histocompatibility complex class I genes

21 January 2018

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator

21 January 2018

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cIRF-3, a new member of the interferon regulatory factor (IRF) family that is rapidly and transiently induced by dsRNA.

21 January 2018

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An interferon regulatory factor-related gene (xIRF-6) is expressed in the posterior mesoderm during the early development of Xenopus laevis

21 January 2018

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Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE).

21 January 2018

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A novel interferon regulatory factor (IRF), IRF-10, has a unique role in immune defense and is induced by the v-Rel oncoprotein

21 January 2018

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Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha

21 January 2018

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A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes

21 January 2018

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IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency

21 January 2018

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Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

21 January 2018

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IRF family of transcription factors as regulators of host defense

21 January 2018

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Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

21 January 2018

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IFN-gamma and IL-4 differently regulate inducible NO synthase gene expression through IRF-1 modulation.

21 January 2018

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Selective expression of type I IFN genes in human dendritic cells infected with Mycobacterium tuberculosis

21 January 2018

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A role for casein kinase II phosphorylation in the regulation of IRF-1 transcriptional activity

21 January 2018

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Activation of IFN-beta element by IRF-1 requires a posttranslational event in addition to IRF-1 synthesis

21 January 2018

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Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system

21 January 2018

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Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

21 January 2018

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Interferon regulatory factor-2 is a transcriptional activator in muscle where It regulates expression of vascular cell adhesion molecule-1.

21 January 2018

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Identification of novel co-repressor molecules for Interferon Regulatory Factor-2

21 January 2018

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Interferon regulatory factors: the next generation

21 January 2018

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Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation

21 January 2018

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X-ray crystal structure of IRF-3 and its functional implications

21 January 2018

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts

21 January 2018

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Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

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Interferon regulatory factor-3 is an in vivo target of DNA-PK.

21 January 2018

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Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25

21 January 2018

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Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: modulation of interferon-regulated gene expression by rel/nuclear factor kappaB.

21 January 2018

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Lineage-specific modulation of interleukin 4 signaling by interferon regulatory factor 4

21 January 2018

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Interferon regulatory factor subcellular localization is determined by a bipartite nuclear localization signal in the DNA-binding domain and interaction with cytoplasmic retention factors

21 January 2018

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Global and distinct targets of IRF-5 and IRF-7 during innate response to viral infection

21 January 2018

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Multiple regulatory domains of IRF-5 control activation, cellular localization, and induction of chemokines that mediate recruitment of T lymphocytes

21 January 2018

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Virus-induced heterodimer formation between IRF-5 and IRF-7 modulates assembly of the IFNA enhanceosome in vivo and transcriptional activity of IFNA genes

21 January 2018

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Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes

21 January 2018

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Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

21 January 2018

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Regulation of the promoter activity of interferon regulatory factor-7 gene. Activation by interferon snd silencing by hypermethylation

21 January 2018

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The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets

21 January 2018

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Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells.

21 January 2018

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Multiple regulatory domains control IRF-7 activity in response to virus infection

21 January 2018

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Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

21 January 2018

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Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3

21 January 2018

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Monocyte differentiation to macrophage requires interferon regulatory factor 7.

21 January 2018

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ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages.

21 January 2018

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Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription

21 January 2018

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Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors

21 January 2018

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PU.1, interferon regulatory factor 1, and interferon consensus sequence-binding protein cooperate to increase gp91(phox) expression

21 January 2018

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Differential Regulation of Interleukin (IL)-12 p35 and p40 Gene Expression and Interferon (IFN)-γ–primed IL-12 Production by IFN Regulatory Factor 1

21 January 2018

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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

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Nitric oxide preferentially induces type 1 T cell differentiation by selectively up-regulating IL-12 receptor beta 2 expression via cGMP

21 January 2018

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Natural killer cells participate in the early defense against Leishmania major infection in mice.

21 January 2018

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Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice

21 January 2018

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Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells

21 January 2018

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Defective development of splenic and epidermal CD4+ dendritic cells in mice deficient for IFN regulatory factor-2.

21 January 2018

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Deficiency in the transcription factor interferon regulatory factor (IRF)-2 leads to severely compromised development of natural killer and T helper type 1 cells

21 January 2018

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An IFN-gamma-inducible transcription factor, IFN consensus sequence binding protein (ICSBP), stimulates IL-12 p40 expression in macrophages

21 January 2018

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Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

21 January 2018

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Dysregulated T helper cell differentiation in the absence of interferon regulatory factor 4.

21 January 2018

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Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression

21 January 2018

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Modulation of T cell cytokine production by interferon regulatory factor-4

21 January 2018

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Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells

21 January 2018

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The role of NF-AT transcription factors in T cell activation and differentiation

21 January 2018

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T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6.

21 January 2018

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Regulation of lymphocyte apoptosis by interferon regulatory factor 4 (IRF-4)

21 January 2018

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Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha- dendritic cell development

21 January 2018

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Crucial role of interferon consensus sequence binding protein, but neither of interferon regulatory factor 1 nor of nitric oxide synthesis for protection against murine listeriosis

21 January 2018

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Interferon (IFN) consensus sequence-binding protein, a transcription factor of the IFN regulatory factor family, regulates immune responses in vivo through control of interleukin 12 expression

21 January 2018

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Interferon consensus sequence binding protein confers resistance against Yersinia enterocolitica

21 January 2018

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Interferon consensus sequence binding protein-deficient mice display impaired resistance to intracellular infection due to a primary defect in interleukin 12 p40 induction

21 January 2018

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IRF3 mediates a TLR3/TLR4-specific antiviral gene program

21 January 2018

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LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF

21 January 2018

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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

21 January 2018

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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway

21 January 2018

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Induction of endogenous IFN-alpha and IFN-beta genes by a regulatory transcription factor, IRF-1.

21 January 2018

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Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo

21 January 2018

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Regulation of DNA-raised immune responses by cotransfected interferon regulatory factors

21 January 2018

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Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies

21 January 2018

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Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

21 January 2018

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The immunology of susceptibility and resistance to Leishmania major in mice

21 January 2018

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The lineage decisions of helper T cells

21 January 2018

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

21 January 2018

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Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment.

21 January 2018

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An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.

21 January 2018

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The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines

21 January 2018

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T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells

21 January 2018

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A novel transcription factor, T-bet, directs Th1 lineage commitment

21 January 2018

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

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Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression

21 January 2018

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Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2.

21 January 2018

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Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon

21 January 2018

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CD8alpha+ and CD8alpha- subclasses of dendritic cells direct the development of distinct T helper cells in vivo

21 January 2018

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Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

21 January 2018

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Essential and non-redundant roles of p48 (ISGF3 gamma) and IRF-1 in both type I and type II interferon responses, as revealed by gene targeting studies

21 January 2018

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Cooperation of the tumour suppressors IRF-1 and p53 in response to DNA damage

21 January 2018

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Requirement for IRF-1 in the microenvironment supporting development of natural killer cells

21 January 2018

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IFN-gamma represses IL-4 expression via IRF-1 and IRF-2

21 January 2018

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Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN alpha and IFN gamma, and is likely to autoregulate the p91 gene.

31 March 2020

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Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

31 March 2020

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Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7

31 March 2020

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Cutting edge: IFN consensus sequence binding protein/IFN regulatory factor 8 drives the development of type I IFN-producing plasmacytoid dendritic cells

31 March 2020

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Phosphorylation events modulate the ability of interferon consensus sequence binding protein to interact with interferon regulatory factors and to bind DNA

31 March 2020

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Interferon regulatory factor-1 is required for a T helper 1 immune response in vivo

31 March 2020

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Multistage regulation of Th1-type immune responses by the transcription factor IRF-1

31 March 2020

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Identification of IFN regulatory factor-1 binding site in IL-12 p40 gene promoter

31 March 2020

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CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling

31 March 2020

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Development of Th1 and not Th2 immune responses in mice lacking IFN-regulatory factor-4

31 March 2020

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Growth factor independent-1 induced by IL-4 regulates Th2 cell proliferation

31 March 2020

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Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function

31 March 2020

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Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma

31 March 2020

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Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster

31 March 2020

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

31 March 2020

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Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1552

1 reference

11 August 2017

1 reference

PubMed ID

15688040