(Q36050056)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Divergent roles of CAAX motif-signaled posttranslational modifications in the regulation and subcellular localization of Ral GTPases (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Motohiro Nishida

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

author name string

Leanna R Gentry

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Akiyuki Nishimura

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Adrienne D Cox

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Timothy D Martin

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Timothy C Elston

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Channing J Der

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

language of work or name

English

0 references

publication date

27 July 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

number of pages

11

1 reference

Journal of Biological Chemistry

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

volume

290

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

issue

37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

page(s)

22851-22861

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

20 February 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4566255/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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2 October 2017

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2 October 2017

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Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

2 October 2017

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2 October 2017

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Identification of a novel prenyl and palmitoyl modification at the CaaX motif of Cdc42 that regulates RhoGDI binding

2 October 2017

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RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane

2 October 2017

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Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization

2 October 2017

1 reference

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Targeting protein prenylation for cancer therapy

2 October 2017

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RALA and RALBP1 regulate mitochondrial fission at mitosis

2 October 2017

1 reference

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The RalGEF-Ral Effector Signaling Network: The Road Less Traveled for Anti-Ras Drug Discovery

2 October 2017

1 reference

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RalB and the exocyst mediate the cellular starvation response by direct activation of autophagosome assembly

2 October 2017

1 reference

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Activation and involvement of Ral GTPases in colorectal cancer

2 October 2017

1 reference

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Phosphorylation of RalB Is Important for Bladder Cancer Cell Growth and Metastasis

2 October 2017

1 reference

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Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms

2 October 2017

1 reference

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RalA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling

2 October 2017

1 reference

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Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA

2 October 2017

1 reference

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Tuberous sclerosis tumor suppressor complex-like complexes act as GTPase-activating proteins for Ral GTPases

2 October 2017

1 reference

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Inactivating Icmt ameliorates K-RAS-induced myeloproliferative disease.

2 October 2017

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Ral GTPases and cancer: linchpin support of the tumorigenic platform

2 October 2017

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Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth

2 October 2017

1 reference

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The tumor suppressor PP2A Abeta regulates the RalA GTPase

2 October 2017

1 reference

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R-Ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes.

2 October 2017

1 reference

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Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells.

2 October 2017

1 reference

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Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease

2 October 2017

1 reference

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RalA and RalB: antagonistic relatives in cancer cell migration

2 October 2017

1 reference

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Activation of RalA is critical for Ras-induced tumorigenesis of human cells.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Identification of V23RalA-Ser194 as a critical mediator for Aurora-A-induced cellular motility and transformation by small pool expression screening.

2 October 2017

1 reference

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Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

RalA but not RalB enhances polarized delivery of membrane proteins to the basolateral surface of epithelial cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

A carboxyl-terminal interaction of lamin B1 is dependent on the CAAX endoprotease Rce1 and carboxymethylation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

RAL GTPases are linchpin modulators of human tumour-cell proliferation and survival

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Epigenetic regulation of ARHI in breast and ovarian cancer cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Isoprenylcysteine carboxyl methyltransferase deficiency in mice

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Ras-dependent activation of the small GTPase Ral.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Post-translational processing of RhoA. Carboxyl methylation of the carboxyl-terminal prenylcysteine increases the half-life of Rhoa

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Coding sequences of human ralA and ralB cDNAs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Posttranslational lipid modification of Rho family small GTPases

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

RalA-exocyst-dependent recycling endosome trafficking is required for the completion of cytokinesis

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Rho Family GTPase modification and dependence on CAAX motif-signaled posttranslational modification

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4566255

Post-prenylation-processing enzymes as new targets in oncogenesis

23 September 2018

1 reference

12 December 2020

Functional significance of beta gamma-subunit carboxymethylation for the activation of phospholipase C and phosphoinositide 3-kinase

1 reference

12 December 2020

Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction

1 reference

12 December 2020

The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M115.656710

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

26216878

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26216878%20AND%20SRC:MED&resulttype=core&format=json