(Q36050308)

11 August 2017

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title

Cilium-generated signaling and cilia-related disorders (English)

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11 August 2017

Junmin Pan

1

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11 August 2017

Qian Wang

series ordinal

2

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11 August 2017

William J Snell

series ordinal

3

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11 August 2017

language of work or name

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1 April 2005

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11 August 2017

Laboratory Investigation

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11 August 2017

85

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11 August 2017

4

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11 August 2017

452-463

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https://scigraph.springernature.com/pub.10.1038/labinvest.3700253

11 August 2017

0 references

cites work

Primary cilia in normal and pathological tissues

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Expression of primary cilia in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A physiological view of the primary cilium

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport and cilia-dependent diseases.

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport and cilia-dependent renal disease: the ciliary hypothesis of polycystic kidney disease.

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Assembly and motility of eukaryotic cilia and flagella. Lessons from Chlamydomonas reinhardtii

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The centrosome in vertebrates: more than a microtubule-organizing center

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Basal body/centriole assembly and continuity

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Elucidation of basal body and centriole functions in Chlamydomonas reinhardtii

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A Human Syndrome Caused by Immotile Cilia

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https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Situs inversus, bronchiectasis, and sinusitis and its relation to immotile cilia: history of the diseases and their discoverers?Manes Kartagener and Bjorn Afzelius

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cilia-related diseases

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cilia are at the heart of vertebrate left-right asymmetry

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Two populations of node monocilia initiate left-right asymmetry in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Determination of left–right patterning of the mouse embryo by artificial nodal flow

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

To beat or not to beat: roles of cilia in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Immotile cilia syndrome associated with polycystic kidney

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cilia and flagella revealed: from flagellar assembly in Chlamydomonas to human obesity disorders

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A motility in the eukaryotic flagellum unrelated to flagellar beating

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar Transport

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport (IFT) cargo: IFT transports flagellar precursors to the tip and turnover products to the cell body

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport balances continuous turnover of outer doublet microtubules: implications for flagellar length control

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The intraflagellar transport machinery of Chlamydomonas reinhardtii

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Inner dynein arms but not outer dynein arms require the activity of kinesin homologue protein KHP1(FLA10) to reach the distal part of flagella in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

An autosomal recessive polycystic kidney disease gene homolog is involved in intraflagellar transport in C. elegans ciliated sensory neurons

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A novel MAP kinase regulates flagellar length in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Defective flagellar assembly and length regulation in LF3 null mutants in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

An aurora kinase is essential for flagellar disassembly in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Regulation of flagellar assembly by glycogen synthase kinase 3 in Chlamydomonas reinhardtii

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The Microtubule plus end-tracking protein EB1 is localized to the flagellar tip and basal bodies in Chlamydomonas reinhardtii

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

EB1 proteins regulate microtubule dynamics, cell polarity, and chromosome stability

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The LF1 gene of Chlamydomonas reinhardtii encodes a novel protein required for flagellar length control

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Aurora kinases in spindle assembly and chromosome segregation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Drosophila KAP interacts with the kinesin II motor subunit KLP64D to assemble chordotonal sensory cilia, but not sperm tails.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport is required in Drosophila to differentiate sensory cilia but not sperm.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cell Motility: Deaf Drosophila Keep the Beat

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Hypoxia regulates assembly of cilia in suppressors of Tetrahymena lacking an intraflagellar transport subunit gene

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A genetic screen in zebrafish identifies cilia genes as a principal cause of cystic kidney

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Intraflagellar transport genes are essential for differentiation and survival of vertebrate sensory neurons.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Murine models of polycystic kidney disease: molecular and therapeutic insights

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Chlamydomonas kinesin-II-dependent intraflagellar transport (IFT): IFT particles contain proteins required for ciliary assembly in Caenorhabditis elegans sensory neurons

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Kidney-specific inactivation of the KIF3A subunit of kinesin-II inhibits renal ciliogenesis and produces polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Role of polycystins in renal tubulogenesis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Genetics and pathogenesis of polycystic kidney disease.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

PKHD1, the polycystic kidney and hepatic disease 1 gene, encodes a novel large protein containing multiple immunoglobulin-like plexin-transcription-factor domains and parallel beta-helix 1 repeats

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Mutations in INVS encoding inversin cause nephronophthisis type 2, linking renal cystic disease to the function of primary cilia and left-right axis determination

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A gene mutated in nephronophthisis and retinitis pigmentosa encodes a novel protein, nephroretinin, conserved in evolution

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cellular and subcellular localization of the ARPKD protein; fibrocystin is expressed on primary cilia.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

PKHD1 protein encoded by the gene for autosomal recessive polycystic kidney disease associates with basal bodies and primary cilia in renal epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polaris, a protein disrupted in orpk mutant mice, is required for assembly of renal cilium

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Delayed cystogenesis and increased ciliogenesis associated with the re-expression of polaris in Tg737 mutant mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polaris, a protein involved in left-right axis patterning, localizes to basal bodies and cilia

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A polycystin-1 multiprotein complex is disrupted in polycystic kidney disease cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The renal cell primary cilium functions as a flow sensor

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Bending the MDCK cell primary cilium increases intracellular calcium

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Bending the primary cilium opens Ca2+-sensitive intermediate-conductance K+ channels in MDCK cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Removal of the MDCK cell primary cilium abolishes flow sensing

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A perspective on inversin

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The ion channel polycystin-2 is required for left-right axis determination in mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A flagellar polycystin-2 homolog required for male fertility in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

A transcriptional network in polycystic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Cell biology of normal and abnormal ciliogenesis in the ciliated epithelium

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

1 reference

7 January 2021

The polycystin-1 C-terminal fragment triggers branching morphogenesis and migration of tubular kidney epithelial cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The oligogenic properties of Bardet-Biedl syndrome

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Bardet-Biedl syndrome type 4 (BBS4)-null mice implicate Bbs4 in flagella formation but not global cilia assembly

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Establishing a connection between cilia and Bardet-Biedl Syndrome

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Beta1-integrins in the primary cilium of MDCK cells potentiate fibronectin-induced Ca2+ signaling

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Selective targeting of somatostatin receptor 3 to neuronal cilia

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Localization of 5-HT(6) receptors at the plasma membrane of neuronal cilia in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Leptin-target neurones of the rat hypothalamus express somatostatin receptors.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Hedgehog signalling in the mouse requires intraflagellar transport proteins

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Analysis of the morphology and function of primary cilia in connective tissues: a cellular cybernetic probe?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

The vertebrate primary cilium is a sensory organelle

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Evidence for role of flagella as sensory transducers in mating of Chlamydomonas reinhardi

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Kinesin-II is required for flagellar sensory transduction during fertilization in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Protein transport and signal transduction during fertilization in chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Flagellar adhesion between mating type plus and mating type minus gametes activates a flagellar protein-tyrosine kinase during fertilization in Chlamydomonas

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

Ultrastructural, tomographic and confocal imaging of the chondrocyte primary cilium in situ.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.3700253

7 January 2021

10.1038/LABINVEST.3700253

Identifiers

DOI

1 reference

Dimensions Publication ID

11 August 2017

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1 reference