(Q36080457)

12 August 2017

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title

Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors (English)

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12 August 2017

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Sheila A Doggrell

1

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12 August 2017

Janet C Wanstall

series ordinal

2

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12 August 2017

publication date

1 February 2005

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Canadian Journal of Physiology and Pharmacology

12 August 2017

published in

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12 August 2017

volume

83

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12 August 2017

issue

2

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12 August 2017

page(s)

123-130

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Cause and effect relationship between myocardial mast cell number and matrix metalloproteinase activity

12 August 2017

cites work

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New developments in the genetics and activation of mast cell proteases

21 January 2018

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Cardiac mast cell-mediated activation of gelatinase and alteration of ventricular diastolic function

21 January 2018

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Compartmentalization of angiotensin II generation in the dog heart. Evidence for independent mechanisms in intravascular and interstitial spaces

21 January 2018

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Vascular chymase: pathophysiological role and therapeutic potential of inhibition

21 January 2018

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Transmural changes in mast cell density in rat heart after infarct induction in vivo.

21 January 2018

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Activation of the cardiac renin-angiotensin system and increased myocardial collagen expression in human aortic valve disease.

21 January 2018

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Evidence for a role of mast cells in the evolution to congestive heart failure

21 January 2018

1 reference

Angiotensins and the failing heart. Enhanced positive inotropic response to angiotensin I in cardiomyopathic hamster heart in the presence of captopril

21 January 2018

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Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension

21 January 2018

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Effects of angiotensin II generated by an angiotensin converting enzyme-independent pathway on left ventricular performance in the conscious baboon

21 January 2018

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Possible roles of cardiac chymase after myocardial infarction in hamster hearts

21 January 2018

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Impact of chymase inhibitor on cardiac function and survival after myocardial infarction

21 January 2018

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Tranilast attenuates myocardial fibrosis in association with suppression of monocyte/macrophage infiltration in DOCA/salt hypertensive rats

21 January 2018

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Radioligand binding reveals chymase as the predominant enzyme for mediating tissue conversion of angiotensin I in the normal human heart

21 January 2018

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Human chymase, an enzyme forming novel bioactive 31-amino acid length endothelins

21 January 2018

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Gene expression of cardiac mast cell chymase and tryptase in a murine model of heart failure caused by viral myocarditis

21 January 2018

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Role for chymase in heart failure: angiotensin II-dependent or -independent mechanisms?

21 January 2018

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Time-dependent expression of chymase and angiotensin converting enzyme in the hamster heart under pressure overload

21 January 2018

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Chymase bound to heparin is resistant to its natural inhibitors and capable of proteolyzing high density lipoproteins in aortic intimal fluid

21 January 2018

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Immunological characterization and functional importance of human heart mast cells

21 January 2018

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Structure–Activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors

21 January 2018

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Chymase Inhibition Prevents Cardiac Fibrosis and Improves Diastolic Dysfunction in the Progression of Heart Failure

21 January 2018

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Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted Peptide

21 January 2018

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Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase

21 January 2018

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Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart

21 January 2018

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Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts

21 January 2018

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A role for cardiac mast cells in the pathogenesis of hypertensive heart disease

21 January 2018

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Cardiac mast cell- and chymase-mediated matrix metalloproteinase activity and left ventricular remodeling in mitral regurgitation in the dog.

21 January 2018

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Increased angiotensin-I converting enzyme gene expression in the failing human heart. Quantification by competitive RNA polymerase chain reaction

21 January 2018

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Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities

21 January 2018

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An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster

21 January 2018

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Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart

21 January 2018

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Angiotensin II formation in the intact human heart. Predominance of the angiotensin-converting enzyme pathway

21 January 2018

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Reduction in Left Ventricular Messenger RNA for Transforming Growth Factor β 1 Attenuates Left Ventricular Fibrosis and Improves Survival Without Lowering Blood Pressure in the Hypertensive TGR(mRen2)27 Rat

21 January 2018

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21 January 2018

Identifiers

DOI

10.1139/Y04-136

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release_7uvkfdnkm5bvjeo66jg3ke2cbe

12 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/7uvkfdnkm5bvjeo66jg3ke2cbe

mapped directly with Wikidata item

24 November 2022

based on heuristic

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