(Q36097224)

12 August 2017

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title

Pharmacokinetic and pharmacodynamic considerations in the development of therapeutic proteins (English)

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12 August 2017

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Iftekhar Mahmood

1

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PubMed ID

15828849

12 August 2017

Martin D Green

series ordinal

2

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12 August 2017

1 January 2005

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Clinical Pharmacokinetics

12 August 2017

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12 August 2017

44

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12 August 2017

4

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12 August 2017

331-347

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https://scigraph.springernature.com/pub.10.2165/00003088-200544040-00001

12 August 2017

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Enhanced lytic efficacy of multiple bolus injections of tissue plasminogen activator in dogs

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12 December 2020

Recombinant proteins for therapy

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12 December 2020

The effect of pulsatile administration, continuous infusion, and diurnal variation on the growth hormone (GH) response to GH-releasing hormone in normal men

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12 December 2020

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

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12 December 2020

Establishment of time-action profiles for regular and NPH insulin using pharmacodynamic modeling

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Incidence and clinical significance of neutralizing antibodies in patients receiving recombinant interferon-alpha 2a.

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12 December 2020

Disposition characteristics of macromolecules in tumor-bearing mice

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Insulin pharmacokinetics following continuous infusion and bolus injection of regular porcine and human insulin in healthy man

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12 December 2020

Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: thigh versus abdomen

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12 December 2020

Pharmacokinetics of recombinant human interferon-gamma in the rhesus monkey after intravenous, intramuscular, and subcutaneous administration

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Simultaneous modeling of pharmacokinetics and pharmacodynamics: application to d-tubocurarine

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12 December 2020

The relevance of pharmacokinetics in the development of biotechnology products

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12 December 2020

Pharmacokinetics and pharmacodynamics of recombinant human erythropoietin after single and multiple subcutaneous doses to healthy subjects.

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12 December 2020

Comparison of four basic models of indirect pharmacodynamic responses

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Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice

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Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator

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Comparative pharmacokinetics of single-dose administration of mammalian and bacterially-derived recombinant human granulocyte-macrophage colony-stimulating factor.

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Protein glycosylation in disease: new insights into the congenital muscular dystrophies

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A soluble, high-affinity, interleukin-4-binding protein is present in the biological fluids of mice

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12 December 2020

Immunogenicity of recombinant DNA human insulin

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12 December 2020

Preclinical studies of recombinant factor IX.

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12 December 2020

Low incidence of serum neutralizing factors in patients receiving recombinant alfa-2b interferon (Intron A)

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12 December 2020

Clinical pharmacology of recombinant human follicle-stimulating hormone. III. Pharmacokinetic-pharmacodynamic modeling after repeated subcutaneous administration

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Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

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12 December 2020

A pharmacodynamic model for pancuronium

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12 December 2020

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12 December 2020

A phase I study of recombinant interleukin 2 plus recombinant beta-interferon

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12 December 2020

Renal handling of low molecular weight proteins

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12 December 2020

Plasma and lymph pharmacokinetics of recombinant human interleukin-2 and polyethylene glycol-modified interleukin-2 in pigs.

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12 December 2020

Use of an indirect pharmacodynamic stimulation model of MX protein induction to compare in vivo activity of interferon alfa-2a and a polyethylene glycol-modified derivative in healthy subjects

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12 December 2020

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12 December 2020

Recombinant human interferon alpha-2a: delivery to lymphoid tissue by selected modes of application

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12 December 2020

Saturable uptake of a recombinant human granulocyte colony-stimulating factor derivative, nartograstim, by the bone marrow and spleen of rats in vivo

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12 December 2020

Pharmacokinetic and pharmacodynamic modeling of recombinant human erythropoietin after intravenous and subcutaneous dose administration in cynomolgus monkeys

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12 December 2020

10.2165/00003088-200544040-00001

Identifiers

DOI

1 reference

PubMed ID

15828849

Dimensions Publication ID

12 August 2017

0 references

1 reference

PubMed ID

15828849