(Q36105649)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

title

LX4211, a dual SGLT1/SGLT2 inhibitor, improved glycemic control in patients with type 2 diabetes in a randomized, placebo-controlled trial (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

0 references

1 reference

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

author name string

B Zambrowicz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

J Freiman

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

P M Brown

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

K S Frazier

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Turnage

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

J Bronner

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

D Ruff

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

M Shadoan

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

P Banks

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

F Mseeh

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

N C Goodwin

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

R Mabon

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

B A Harrison

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Wilson

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

A Sands

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

D R Powell

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

language of work or name

English

0 references

publication date

4 July 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

Clinical Pharmacology & Therapeutics

6 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

volume

92

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

page(s)

158-169

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

Biology of human sodium glucose transporters

6 February 2020

cites work

1 reference

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A novel approach to control hyperglycemia in type 2 diabetes: sodium glucose co-transport (SGLT) inhibitors: systematic review and meta-analysis of randomized trials

2 October 2017

1 reference

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2 October 2017

1 reference

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Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial

2 October 2017

1 reference

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SGLT2 inhibition--a novel strategy for diabetes treatment

2 October 2017

1 reference

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Weight loss, glycemic control, and changes in cardiovascular biomarkers in patients with type 2 diabetes receiving incretin therapies or insulin in a large cohort database

2 October 2017

1 reference

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Projecting the future diabetes population size and related costs for the U.S.

2 October 2017

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Defining and characterizing the progression of type 2 diabetes

2 October 2017

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Statement by an American Association of Clinical Endocrinologists/American College of Endocrinology consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control

2 October 2017

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Evolution of sodium glucose co-transporter 2 inhibitors as anti-diabetic agents

2 October 2017

1 reference

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Efficacy and safety of incretin based therapies: clinical trial data

2 October 2017

1 reference

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A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatment

2 October 2017

1 reference

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Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials

2 October 2017

1 reference

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Endocrine mechanisms mediating remission of diabetes after gastric bypass surgery

2 October 2017

1 reference

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Mechanisms of glucose homeostasis after Roux-en-Y gastric bypass surgery in the obese, insulin-resistant Zucker rat

2 October 2017

1 reference

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Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes

2 October 2017

1 reference

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Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes

2 October 2017

1 reference

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Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

2 October 2017

1 reference

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10-year follow-up of intensive glucose control in type 2 diabetes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats

2 October 2017

1 reference

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Biology of incretins: GLP-1 and GIP

2 October 2017

1 reference

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Primary prevention of cardiovascular diseases in people with diabetes mellitus: a scientific statement from the American Heart Association and the American Diabetes Association

2 October 2017

1 reference

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THE EFFECTS ON RENAL ACTIVITY OF THE ORAL ADMINISTRATION OF PHLORIZIN IN MAN.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Peptide YY(1-36) and peptide YY(3-36): Part I. Distribution, release and actions

2 October 2017

1 reference

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Intensive Diabetes Treatment and Cardiovascular Disease in Patients with Type 1 Diabetes

2 October 2017

1 reference

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2 October 2017

1 reference

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Sensory nerves contribute to insulin secretion by glucagon-like peptide-1 in mice

2 October 2017

1 reference

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Bioavailability of phloretin and phloridzin in rats.

2 October 2017

1 reference

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Phloretin differentially inhibits volume-sensitive and cyclic AMP-activated, but not Ca-activated, Cl(-) channels

2 October 2017

1 reference

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Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095

2 October 2017

1 reference

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

2 October 2017

1 reference

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Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group

2 October 2017

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The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group

2 October 2017

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Homeostasis model assessment: insulin resistance and ?-cell function from fasting plasma glucose and insulin concentrations in man

2 October 2017

1 reference

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Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats

2 October 2017

1 reference

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Prediction of creatinine clearance from serum creatinine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Short-chain fatty acid release of peptide YY in the isolated rabbit distal colon

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Carboxyl group-terminated polyamidoamine dendrimers bearing glucosides inhibit intestinal hexose transporter-mediated D-glucose uptake

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Simple pharmacometric tools for oral anti-diabetic drug development: competitive landscape for oral non-insulin therapies in type 2 diabetes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Novel L-xylose derivatives as selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitus

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Including indigestible carbohydrates in the evening meal of healthy subjects improves glucose tolerance, lowers inflammatory markers, and increases satiety after a subsequent standardized breakfast.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Polymer-phloridzin conjugates as an anti-diabetic drug that inhibits glucose absorption through the Na+/glucose cotransporter (SGLT1) in the small intestine

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Glucagon-like peptide-1 excites pancreas-projecting preganglionic vagal motoneurons.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Coefficient of failure: a methodology for examining longitudinal beta-cell function in Type 2 diabetes

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

I. Glucose galactose malabsorption.

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

The functional involvement of gut-expressed sweet taste receptors in glucose-stimulated secretion of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY)

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3400893

Portal GLP-1 administration in rats augments the insulin response to glucose via neuronal mechanisms

21 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22739142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Phloretin - an uncoupler and an inhibitor of mitochondrial oxidative phosphorylation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22739142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22739142

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CLPT.2012.58

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22739142%20AND%20SRC:MED&resulttype=core&format=json