(Q36110556)

English

Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Connectivity map analysis of nonsense-mediated decay-positive BMPR2-related hereditary pulmonary arterial hypertension provides insights into disease penetrance (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

arterial hypertension

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Charles Robert Flynn

1

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22 January 2020

James David West

10

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22 January 2020

author name string

Siyuan Zheng

2

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22 January 2020

Ling Yan

3

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22 January 2020

Lora Hedges

4

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22 January 2020

Bethany Womack

5

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22 January 2020

Josh Fessel

6

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22 January 2020

Joy Cogan

7

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22 January 2020

Eric Austin

8

1 reference

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22 January 2020

James Loyd

9

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22 January 2020

Zhongming Zhao

11

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22 January 2020

Rizwan Hamid

12

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22 January 2020

publication date

3 February 2012

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22 January 2020

American Journal of Respiratory Cell and Molecular Biology

1 reference

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22 January 2020

47

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22 January 2020

1

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22 January 2020

20-27

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Idiopathic and heritable PAH perturb common molecular pathways, correlated with increased MSX1 expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Oxidative injury is a common consequence of BMPR2 mutations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Microarray studies in pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Mitochondrial metabolic adaptation in right ventricular hypertrophy and failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Discovering disease-specific biomarker genes for cancer diagnosis and prognosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

A proposed mitochondrial-metabolic mechanism for initiation and maintenance of pulmonary arterial hypertension in fawn-hooded rats: the Warburg model of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Penetrance of pulmonary arterial hypertension is modulated by the expression of normal BMPR2 allele

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Gene expression in BMPR2 mutation carriers with and without evidence of pulmonary arterial hypertension suggests pathways relevant to disease penetrance

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Molecular pathogenesis of pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Narrative review: the enigma of pulmonary arterial hypertension: new insights from genetic studies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Proteomics of transformed lymphocytes from a family with familial pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

The Connectivity Map: a new tool for biomedical research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Functional interaction between BMPR-II and Tctex-1, a light chain of Dynein, is isoform-specific and disrupted by mutations underlying primary pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

An efficient method for the rapid establishment of Epstein-Barr virus immortalization of human B lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Nonsense-mediated mRNA decay in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Gene expression patterns in the lungs of patients with primary pulmonary hypertension: a gene microarray analysis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Excitation-contraction coupling in pulmonary vascular smooth muscle involves tyrosine kinase and Rho kinase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 October 2017

The cancer paradigm of severe pulmonary arterial hypertension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 July 2018

Rho/Rho kinase signaling mediates increased basal pulmonary vascular tone in chronically hypoxic rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 July 2018

Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein–Barr virus-induced B-cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3402799

2 July 2018

Survival in primary pulmonary hypertension: the impact of epoprostenol therapy.

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

High frequency of BMPR2 exonic deletions/duplications in familial pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

Somatic mutations in pulmonary arterial hypertension: primary or secondary events?

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

Role of PKC, tyrosine kinases, and Rho kinase in alpha-adrenoreceptor-mediated PASM contraction

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

Bone morphogenetic protein receptor type II C-terminus interacts with c-Src: implication for a role in pulmonary arterial hypertension

1 reference

https://api.crossref.org/works/10.1165%2FRCMB.2011-0251OC

21 January 2018

The connectivity map

1 reference

https://pubmed.ncbi.nlm.nih.gov/22312021

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gross BMPR2 gene rearrangements constitute a new cause for primary pulmonary hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22312021

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synergistic heterozygosity for TGFbeta1 SNPs and BMPR2 mutations modulates the age at diagnosis and penetrance of familial pulmonary arterial hypertension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22312021

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1165/RCMB.2011-0251OC

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22312021%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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