(Q36117484)

English

Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Two protein kinase C isoforms, δ and ε, regulate energy homeostasis in mitochondria by transmitting opposing signals to the pyruvate dehydrogenase complex (English)

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

author name string

Jianli Gong

1

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Beatrice Hoyos

2

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Rebeca Acin-Perez

3

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Valerie Vinogradov

4

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Elena Shabrova

5

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Feng Zhao

6

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Michael Leitges

7

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Donald Fischman

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Giovanni Manfredi

9

1 reference

Europe PubMed Central

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12 August 2017

Ulrich Hammerling

10

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Europe PubMed Central

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12 August 2017

language of work or name

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publication date

9 May 2012

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Europe PubMed Central

PMC publication ID

12 August 2017

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

26

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

8

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

3537-3549

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

Hiding in plain sight: uncovering a new function of vitamin A in redox signaling

1 reference

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PKCδ regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans

1 reference

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Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses

1 reference

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Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules

1 reference

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Are zinc-finger domains of protein kinase C dynamic structures that unfold by lipid or redox activation?

1 reference

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Regulation of intermediary metabolism by the PKCδ signalosome in mitochondria

1 reference

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Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

1 reference

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Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.

1 reference

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Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

1 reference

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Control of oxidative phosphorylation by vitamin A illuminates a fundamental role in mitochondrial energy homoeostasis

1 reference

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A ceramide-binding C1 domain mediates kinase suppressor of ras membrane translocation

1 reference

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2 October 2017

Protein kinase C in heart failure: a therapeutic target?

1 reference

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Proteomic and metabolomic analysis of cardioprotection: Interplay between protein kinase C epsilon and delta in regulating glucose metabolism of murine hearts

1 reference

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Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer.

1 reference

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2 October 2017

Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP-1-dependent energy deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Cardioprotective mechanisms of PKC isozyme-selective activators and inhibitors in the treatment of ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Assay of mitochondrial ATP synthesis in animal cells and tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

PKC delta phosphorylates p52ShcA at Ser29 to regulate ERK activation in response to H2O2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Mechanisms of fenretinide-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Regulation of the pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

A versatile tool for conditional gene expression and knockdown

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Protein kinase Cepsilon interacts with cytochrome c oxidase subunit IV and enhances cytochrome c oxidase activity in neonatal cardiac myocyte preconditioning

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

The role of protein kinase C in cerebral ischemic and reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Tyrosine phosphorylation in mitochondria: a new frontier in mitochondrial signaling.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Homocysteine and reactive oxygen species in metabolic syndrome, type 2 diabetes mellitus, and atheroscleropathy: the pleiotropic effects of folate supplementation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Protein kinase C delta (PKC delta): activation mechanisms and functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Regulation of the activity of the pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

PKC epsilon controls the traffic of beta1 integrins in motile cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Exacerbated vein graft arteriosclerosis in protein kinase Cdelta-null mice

1 reference

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2 October 2017

In vivo regulation of oxidative phosphorylation in cells harboring a stop-codon mutation in mitochondrial DNA-encoded cytochrome c oxidase subunit I.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Opposing cardioprotective actions and parallel hypertrophic effects of delta PKC and epsilon PKC.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Regulation of pyruvate dehydrogenase activity through phosphorylation at multiple sites

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Functional proteomic analysis of protein kinase C epsilon signaling complexes in the normal heart and during cardioprotection

1 reference

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Retinoids as ligands and coactivators of protein kinase C alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

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The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors

1 reference

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2 October 2017

Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

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Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Retro-retinoids in regulated cell growth and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy

1 reference

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Anhydroretinol: a naturally occurring inhibitor of lymphocyte physiology

1 reference

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Rottlerin, a novel protein kinase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Diversity of the pyruvate dehydrogenase kinase gene family in humans

1 reference

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2 October 2017

Molecular biology and biochemistry of pyruvate dehydrogenase complexes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Interactions of retinol with binding proteins: studies with rat cellular retinol-binding protein and with rat retinol-binding protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

The elementary reactions of the pig heart pyruvate dehydrogenase complex. A study of the inhibition by phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 October 2017

Protein kinase C-epsilon coimmunoprecipitates with cytochrome oxidase subunit IV and is associated with improved cytochrome-c oxidase activity and cardioprotection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

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Targeting of protein kinase C delta to mitochondria in the oxidative stress response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 July 2018

F-actin as a functional target for retro-retinoids: a potential role in anhydroretinol-triggered cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 July 2018

Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 July 2018

Measurement of subnanomolar retinoic acid binding affinities for cellular retinoic acid binding proteins by fluorometric titration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

2 July 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

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Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Epidermal growth factor receptor phosphorylates protein kinase C {delta} at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Reperfusion-induced translocation of deltaPKC to cardiac mitochondria prevents pyruvate dehydrogenase reactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Regulation of the cardiac mitochondrial membrane potential by retinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Isolation of biogenetically competent mitochondria from mammalian tissues and cultured cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3405274

23 September 2018

Anhydroretinol induces oxidative stress and cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/22573912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22573912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-(4-hydroxyphenyl)retinamide in the chemoprevention of squamous metaplasia and dysplasia of the bronchial epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22573912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thermodynamic parameters of the binding of retinol to binding proteins and to membranes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22573912

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1096/FJ.11-197376

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

12 August 2017

ResearchGate publication ID

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