(Q36120766)

12 August 2017

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title

Investigational anti-inflammatory agents for the treatment of ischaemic brain injury (English)

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12 August 2017

Xinkang Wang

1

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12 August 2017

language of work or name

English

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publication date

1 April 2005

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Expert Opinion on Investigational Drugs

12 August 2017

published in

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12 August 2017

volume

14

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12 August 2017

issue

4

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12 August 2017

page(s)

393-409

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An update on thrombolytic therapy for acute stroke

12 August 2017

cites work

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Use of anti-ICAM-1 therapy in ischemic stroke: results of the Enlimomab Acute Stroke Trial

21 January 2018

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An overview of acute stroke therapy: past, present, and future

21 January 2018

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Inflammatory mediators and stroke: new opportunities for novel therapeutics

21 January 2018

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Involvement of inflammatory cytokines in central nervous system injury

21 January 2018

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Therapeutic potential of anti-inflammatory drugs in focal stroke

21 January 2018

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Inflammation in central nervous system injury

21 January 2018

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Neurogenesis and apoptotic cell death.

21 January 2018

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Apoptosis and brain ischaemia

21 January 2018

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Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

21 January 2018

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Inflammation and infections as risk factors for ischemic stroke

21 January 2018

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Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor

21 January 2018

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Monocyte chemoattractant protein-1 deficiency is protective in a murine stroke model.

21 January 2018

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Overexpression of monocyte chemoattractant protein 1 in the brain exacerbates ischemic brain injury and is associated with recruitment of inflammatory cells

21 January 2018

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Chemokine receptor antagonist peptide, viral MIP-II, protects the brain against focal cerebral ischemia in mice.

21 January 2018

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CD18-mediated neutrophil recruitment contributes to the pathogenesis of reperfused but not nonreperfused stroke

21 January 2018

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Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury

21 January 2018

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Intercellular adhesion molecule-1-deficient mice are less susceptible to cerebral ischemia-reperfusion injury.

21 January 2018

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Exacerbation of cerebral injury in mice that express the P-selectin gene: identification of P-selectin blockade as a new target for the treatment of stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

A critical role of neural-specific JNK3 for ischemic apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

CD44 deficiency in mice protects brain from cerebral ischemia injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

21 January 2018

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Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

The transcription factor interferon regulatory factor 1 is expressed after cerebral ischemia and contributes to ischemic brain injury

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ss1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

IL-10 reduces rat brain injury following focal stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Postischemic cerebrovascular E-selectin expression mediates tissue injury in murine stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Anti-CD11b monoclonal antibody reduces ischemic cell damage after transient focal cerebral ischemia in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Monoclonal antibody to the ICAM-1 adhesion site reduces neurological damage in a rabbit cerebral embolism stroke model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Postischemic (6-Hour) treatment with recombinant human tissue plasminogen activator and proteasome inhibitor PS-519 reduces infarction in a rat model of embolic focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Delayed treatment of ischemia/reperfusion brain injury: extended therapeutic window with the proteosome inhibitor MLN519.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Anti-inflammatory, antithrombotic, and neuroprotective effects of activated protein C in a murine model of focal ischemic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Elevation of tumor necrosis factor in head injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Release of proinflammatory and prothrombotic mediators in the brain and peripheral circulation in spontaneously hypertensive and normotensive Wistar-Kyoto rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Closed head injury triggers early production of TNF alpha and IL-6 by brain tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Tumor necrosis factor-alpha expression in ischemic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Matrix metalloproteinases and TIMPs are associated with blood-brain barrier opening after reperfusion in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Functions and mechanisms of interleukin 1 in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Effects of kainic acid on messenger RNA levels of IL-1 beta, IL-6, TNF alpha and LIF in the rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Induction of interleukin-1 beta mRNA in rat brain after transient forebrain ischemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Interleukin 1 in the brain: biology, pathology and therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Interleukin-1 receptor and receptor antagonist gene expression after focal stroke in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Attenuation of stroke size in rats using an adenoviral vector to induce overexpression of interleukin-1 receptor antagonist in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Ischemic preconditioning and brain tolerance: temporal histological and functional outcomes, protein synthesis requirement, and interleukin-1 receptor antagonist and early gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Demonstration of increased endothelial-leukocyte adhesion molecule-1 mRNA expression in rat ischemic cortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Antibodies against adhesion molecules reduce apoptosis after transient middle cerebral artery occlusion in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Reduction of central nervous system ischemic injury by monoclonal antibody to intercellular adhesion molecule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Increased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inflammatory responses to ischemia and reperfusion in the cerebral microcirculation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Monoclonal antibodies preventing leukocyte activation reduce experimental neurologic injury and enhance efficacy of thrombolytic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Experimental antileukocyte interventions in cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Examination of several potential mechanisms for the negative outcome in a clinical stroke trial of enlimomab, a murine anti-human intercellular adhesion molecule-1 antibody: a bedside-to-bench study

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Nitric oxide synthases: properties and catalytic mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Bright and dark sides of nitric oxide in ischemic brain injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Prostaglandin endoperoxide synthase: structure and catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Spreading depression and focal brain ischemia induce cyclooxygenase-2 in cortical neurons through N-methyl-D-aspartic acid-receptors and phospholipase A2

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Interaction between inducible nitric oxide synthase and cyclooxygenase-2 after cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Interactions of nitric oxide with cyclooxygenase: in vitro, ex vivo, and in vivo studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

The Janus face of cyclooxygenase-2 in ischemic stroke: shifting toward downstream targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Organization and regulation of mitogen-activated protein kinase signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Neurotrophic molecules: strategies for designing effective therapeutic molecules in neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Inhibition of MEK/ERK 1/2 pathway reduces pro-inflammatory cytokine interleukin-1 expression in focal cerebral ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Interleukin-1 mediates induction of tolerance to global ischemia in gerbil hippocampal CA1 neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

A Role for Interferon-Gamma in Focal Cerebral Ischemia in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.14.4.393

10.1517/13543784.14.4.393

21 January 2018

Identifiers

DOI

1 reference

12 August 2017

1 reference