(Q36137565)

12 August 2017

Complexin arrests a pool of docked vesicles for fast Ca2+-dependent release (English)

1 reference

12 August 2017

Jörg Malsam

1

1 reference

12 August 2017

Daniel Parisotto

2

1 reference

12 August 2017

Tanmay A M Bharat

3

1 reference

12 August 2017

Andrea Scheutzow

4

1 reference

12 August 2017

Jean Michel Krause

5

1 reference

12 August 2017

John A G Briggs

6

1 reference

12 August 2017

Thomas H Söllner

7

1 reference

12 August 2017

language of work or name

English

0 references

publication date

15 June 2012

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12 August 2017

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12 August 2017

31

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12 August 2017

15

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12 August 2017

3270-3281

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describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3411073/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold

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Solution single-vesicle assay reveals PIP2-mediated sequential actions of synaptotagmin-1 on SNAREs

2 October 2017

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Reconstituted synaptotagmin I mediates vesicle docking, priming, and fusion

2 October 2017

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Complexin cross-links prefusion SNAREs into a zigzag array

2 October 2017

1 reference

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Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

2 October 2017

1 reference

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In vitro system capable of differentiating fast Ca2+-triggered content mixing from lipid exchange for mechanistic studies of neurotransmitter release

2 October 2017

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Phosphatidylinositol 4,5-bisphosphate alters synaptotagmin 1 membrane docking and drives opposing bilayers closer together

2 October 2017

1 reference

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Membrane penetration by synaptotagmin is required for coupling calcium binding to vesicle fusion in vivo

2 October 2017

1 reference

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Complexin maintains vesicles in the primed state in C. elegans

2 October 2017

1 reference

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Complexin clamps asynchronous release by blocking a secondary Ca(2+) sensor via its accessory α helix

2 October 2017

1 reference

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Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1

2 October 2017

1 reference

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A fast, single-vesicle fusion assay mimics physiological SNARE requirements

2 October 2017

1 reference

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Tilting the balance between facilitatory and inhibitory functions of mammalian and Drosophila Complexins orchestrates synaptic vesicle exocytosis.

2 October 2017

1 reference

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Helical extension of the neuronal SNARE complex into the membrane

2 October 2017

1 reference

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A role of complexin-lipid interactions in membrane fusion

2 October 2017

1 reference

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The carboxy-terminal domain of complexin I stimulates liposome fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexin controls the force transfer from SNARE complexes to membranes in fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Alternative zippering as an on-off switch for SNARE-mediated fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Direct interaction of SNARE complex binding protein synaphin/complexin with calcium sensor synaptotagmin 1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Membrane fusion: SNAREs and regulation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

2 October 2017

Synaptic vesicle fusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexin and Ca2+ stimulate SNARE-mediated membrane fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexins facilitate neurotransmitter release at excitatory and inhibitory synapses in mammalian central nervous system.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Mechanisms of membrane fusion: disparate players and common principles.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

How does synaptotagmin trigger neurotransmitter release?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin activates membrane fusion through a Ca2+-dependent trans interaction with phospholipids

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

How synaptotagmin promotes membrane fusion.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Molecular anatomy of a trafficking organelle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

SNAREs--engines for membrane fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

A clamping mechanism involved in SNARE-dependent exocytosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Genetic analysis of synaptotagmin 2 in spontaneous and Ca2+-triggered neurotransmitter release

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Presynaptic calcium and control of vesicle fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Structurally and functionally unique complexins at retinal ribbon synapses

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Crystallographic identification of Ca2+ and Sr2+ coordination sites in synaptotagmin I C2B domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

The synaptic vesicle cycle

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Fusion of cells by flipped SNAREs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin I increases the probability of vesicle fusion at low [Ca2+] in pituitary cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Three-dimensional structure of the complexin/SNARE complex

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmins form a hierarchy of exocytotic Ca(2+) sensors with distinct Ca(2+) affinities

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmins: why so many?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Intracellular calcium dependence of large dense-core vesicle exocytosis in the absence of synaptotagmin I

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin I functions as a calcium regulator of release probability

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexins regulate a late step in Ca2+-dependent neurotransmitter release

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R-SNAREs

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 A resolution

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

SNAREpins: minimal machinery for membrane fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

SNAP receptors implicated in vesicle targeting and fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin I: a major Ca2+ sensor for transmitter release at a central synapse

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium dependence of the rate of exocytosis in a synaptic terminal

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Complexins: cytosolic proteins that regulate SNAP receptor function

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Use of resonance energy transfer to monitor membrane fusion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin perturbs the structure of phospholipid bilayers

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Calcium-independent stimulation of membrane fusion and SNAREpin formation by synaptotagmin I.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

A role for synaptotagmin (p65) in regulated exocytosis

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

CHELATOR: an improved method for computing metal ion concentrations in physiological solutions.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

PIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.

2 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

The C2A domain of synaptotagmin alters the kinetics of voltage-gated Ca2+ channels Ca(v)1.2 (Lc-type) and Ca(v)2.3 (R-type).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Reconstitution of depolarization and Ca2+-evoked secretion in Xenopus oocytes monitored by membrane capacitance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

A complexin fusion clamp regulates spontaneous neurotransmitter release and synaptic growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Drosophila synaptotagmin I null mutants show severe alterations in vesicle populations but calcium-binding motif mutants do not.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Distinct domains of complexin I differentially regulate neurotransmitter release

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Mutations in the second C2 domain of synaptotagmin disrupt synaptic transmission at Drosophila neuromuscular junctions

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3411073

Synaptotagmin-1 Docks Secretory Vesicles to Syntaxin-1/SNAP-25 Acceptor Complexes

23 September 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Real-time measurement of transmitter release from single synaptic vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2012.164

Functional analysis of the C2A domain of synaptotagmin 1: implications for calcium-regulated secretion

21 January 2018

1 reference

12 December 2020

N- to C-Terminal SNARE Complex Assembly Promotes Rapid Membrane Fusion

1 reference

12 December 2020

Energetics and dynamics of SNAREpin folding across lipid bilayers

1 reference

12 December 2020

Activity-dependent changes in partial VAMP complexes during neurotransmitter release

1 reference

12 December 2020

Transfection analysis of functional roles of complexin I and II in the exocytosis of two different types of secretory vesicles

1 reference

12 December 2020

Synaptotagmin function in dense core vesicle exocytosis studied in cracked PC12 cells

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2012.164

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22705946

1 reference