(Q36148448)

12 August 2017

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title

Blocking adhesion molecules as therapy for multiple sclerosis: natalizumab (English)

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12 August 2017

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Lawrence Steinman

1

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12 August 2017

1 June 2005

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Nature Reviews Drug Discovery

12 August 2017

9

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based on heuristic

inferred from page(s)

published in

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12 August 2017

4

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12 August 2017

6

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12 August 2017

510-518

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https://scigraph.springernature.com/pub.10.1038/nrd1752

12 August 2017

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cites work

Current disease-modifying therapies in multiple sclerosis

1 reference

Diverse targets for intervention during inflammatory and neurodegenerative phases of multiple sclerosis

21 January 2018

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Transcriptional analysis of targets in multiple sclerosis

21 January 2018

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Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.

21 January 2018

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Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm

21 January 2018

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Lymphocyte homing and homeostasis

21 January 2018

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T-Cell Function and Migration — Two Sides of the Same Coin

21 January 2018

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In vivo effects of antibodies to immune response gene products: prevention of experimental allergic encephalitis

21 January 2018

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Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody. Decreased accumulation of radiolabelled lymph node cells in the central nervous system.

21 January 2018

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Anti I-A antibody suppresses active encephalomyelitis: treatment model for diseases linked to IR genes

21 January 2018

1 reference

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination.

21 January 2018

1 reference

Lymphocyte homing into lymph nodes: in vitro demonstration of the selective affinity of recirculating lymphocytes for high-endothelial venules

21 January 2018

1 reference

Antibodies to CD44 and integrin alpha4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment

21 January 2018

1 reference

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma

21 January 2018

1 reference

A monoclonal antibody to alpha 4 integrin suppresses and reverses active experimental allergic encephalomyelitis

21 January 2018

1 reference

Inhibition of insulitis and prevention of diabetes in nonobese diabetic mice by blocking L-selectin and very late antigen 4 adhesion receptors

21 January 2018

1 reference

A predominant role of integrin alpha 4 in the spontaneous development of autoimmune diabetes in nonobese diabetic mice

21 January 2018

1 reference

In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection

21 January 2018

1 reference

Discordant effects of anti-VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

The effect of anti-alpha4 integrin antibody on brain lesion activity in MS. The UK Antegren Study Group.

21 January 2018

1 reference

A controlled trial of natalizumab for relapsing multiple sclerosis.

21 January 2018

1 reference

Alpha4beta1 integrin acts as a cell receptor for murine polyomavirus at the postattachment level

21 January 2018

1 reference

Vaccination against autoimmune encephalomyelitis with T-lymphocite line cells reactive against myelin basic protein

21 January 2018

1 reference

Multiple sclerosis: a two-stage disease

21 January 2018

1 reference

Multiple sclerosis: trapped in deadly glue

31 March 2020

1 reference

Evidence for a prolonged role of alpha 4 integrin throughout active experimental allergic encephalomyelitis

31 March 2020

1 reference

A safety and pharmacokinetic study of intravenous natalizumab in patients with MS

31 March 2020

1 reference

Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: critical importance of timing of treatment

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1752

1 reference

12 August 2017

1 reference

PubMed ID

15931259