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Modeling resistance to pathway-targeted therapy in ovarian cancer
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
review article
1 reference
stated in
Europe PubMed Central
title
Modeling resistance to pathway-targeted therapy in ovarian cancer
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
main subject
ovarian cancer
1 reference
based on heuristic
inferred from title
author name string
Deyin Xing
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
Sandra Orsulic
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
publication date
25 August 2005
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
published in
Cell Cycle
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
volume
4
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
issue
8
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
page(s)
1004-1006
1 reference
stated in
Europe PubMed Central
PMCID
2268865
retrieved
12 August 2017
cites work
A genetically defined mouse ovarian carcinoma model for the molecular characterization of pathway-targeted therapy and tumor resistance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Combination of the mTOR inhibitor rapamycin and CC-5013 has synergistic activity in multiple myeloma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
In vivo antitumor effects of the mTOR inhibitor CCI-779 against human multiple myeloma cells in a xenograft model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
p21Waf1/Cip1 as a therapeutic target in breast and other cancers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Targeting mTOR signaling for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Targeting RAS signalling pathways in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
An RCAS-TVA-based approach to designer mouse models
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Inhibitors of mTOR reverse doxorubicin resistance conferred by PTEN status in prostate cancer cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Induction of ovarian cancer by defined multiple genetic changes in a mouse model system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-Pro motif and is activated by antibodies to a region near its COOH terminus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
High-intensity Raf signal causes cell cycle arrest mediated by p21Cip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
1 October 2017
AKT and mTOR phosphorylation is frequently detected in ovarian cancer and can be targeted to disrupt ovarian tumor cell growth
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
2 July 2018
Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
2 July 2018
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
The zinc finger protein GLI induces cellular sensitivity to the mTOR inhibitor rapamycin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Cooperating oncogenes converge to regulate cyclin/cdk complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2268865
retrieved
23 September 2018
Identifiers
DOI
10.4161/CC.4.8.1869
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rfqq6hxz25fkdjagqtsj4jumfa
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
Fatcat ID
release_rfqq6hxz25fkdjagqtsj4jumfa
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rfqq6hxz25fkdjagqtsj4jumfa
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
PMCID
2268865
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rfqq6hxz25fkdjagqtsj4jumfa
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
PubMed ID
15970711
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/rfqq6hxz25fkdjagqtsj4jumfa
retrieved
30 July 2022
based on heuristic
mapped directly with Wikidata item
ResearchGate publication ID
7772209
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