(Q36179778)

12 August 2017

title

Gene-directed enzyme prodrug therapy: a review of enzyme/prodrug combinations (English)

1 reference

12 August 2017

Niculescu-Duvaz I

1

1 reference

12 August 2017

Springer CJ

series ordinal

2

1 reference

12 August 2017

language of work or name

English

0 references

publication date

1 June 1997

1 reference

Expert Opinion on Investigational Drugs

12 August 2017

published in

1 reference

12 August 2017

volume

6

1 reference

12 August 2017

issue

6

1 reference

12 August 2017

page(s)

685-703

1 reference

Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

12 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Direct cell killing by suicide genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Gene therapy against cancer and HIV infection using the gene encoding herpes simplex virus thymidine kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Targeting enzymes for cancer therapy: old enzymes in new roles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Nonviral gene therapy: the promise of genes as pharmaceutical products

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Gene transfer with synthetic cationic amphiphiles: prospects for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Anabolic pathway of 6-methoxypurine arabinoside in cells infected with varicella-zoster virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Control of eukaryotic messenger RNA synthesis by sequence-specific DNA-binding proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

The chemotherapeutic exploitation of virus-specified enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Transduction of the herpes thymidine kinase gene into premalignant murine mammary epithelial cells renders subsequent breast cancers responsive to ganciclovir therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Targeting of an inducible toxic phenotype in animal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Regression of established macroscopic liver metastases after in situ transduction of a suicide gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

In vivo gene therapy of ovarian cancer by adenovirus-mediated thymidine kinase gene transduction and ganciclovir administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Prostate cancer gene therapy: herpes simplex virus thymidine kinase gene transduction followed by ganciclovir in mouse and human prostate cancer models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Regional delivery of an adenovirus vector containing the Escherichia coli cytosine deaminase gene to provide local activation of 5-fluorocytosine to suppress the growth of colon carcinoma metastatic to liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Adenine as Substrate for Purine Nucleoside Phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Viral vector transduction of the human deoxycytidine kinase cDNA sensitizes glioma cells to the cytotoxic effects of cytosine arabinoside in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: a case for distinct proteolytic mechanisms?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16. Use of a novel triazine dye affinity method

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Tumour-growth inhibitorynitrofphenylaziridines and related compounds structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Phenotypic conversion of TK-deficient cells following electroporation of functional TK enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.6.6.685

21 January 2018

Identifiers

DOI

10.1517/13543784.6.6.685

1 reference

12 August 2017

1 reference