(Q36191594)

12 August 2017

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title

Is the GABA B heterodimer a good drug target? (English)

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12 August 2017

Fiona H Marshall

1

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12 August 2017

language of work or name

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1 January 2005

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Journal of Molecular Neuroscience

12 August 2017

published in

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12 August 2017

volume

26

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12 August 2017

issue

2-3

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12 August 2017

page(s)

169-176

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https://scigraph.springernature.com/pub.10.1385/jmn:26:2-3:169

12 August 2017

exact match

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cites work

Gastroesophageal reflux disease and baclofen: is there a light at the end of the tunnel?

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12 December 2020

Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function

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12 December 2020

RAMPs: accessory proteins for seven transmembrane domain receptors

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12 December 2020

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

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12 December 2020

GPCR drug discovery through the exploitation of allosteric drug binding sites

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12 December 2020

Distribution of a GABAB-like receptor protein in the rat central nervous system

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12 December 2020

Allosteric modulators of group I metabotropic glutamate receptors: novel subtype-selective ligands and therapeutic perspectives.

1 reference

12 December 2020

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

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12 December 2020

Opposite effects of GABAB receptor antagonists on absences and convulsive seizures.

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12 December 2020

Multiple GABAB receptors

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12 December 2020

Defective gamma-aminobutyric acid type B receptor-activated inwardly rectifying K+ currents in cerebellar granule cells isolated from weaver and Girk2 null mutant mice

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12 December 2020

GABA(B) receptors as potential therapeutic targets

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12 December 2020

Effects of repeated cocaine on medial prefrontal cortical GABAB receptor modulation of neurotransmission in the mesocorticolimbic dopamine system

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12 December 2020

A trafficking checkpoint controls GABA(B) receptor heterodimerization

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12 December 2020

Molecular determinants involved in the allosteric control of agonist affinity in the GABAB receptor by the GABAB2 subunit.

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12 December 2020

Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking

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12 December 2020

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

1 reference

12 December 2020

The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice

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12 December 2020

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

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12 December 2020

Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice

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12 December 2020

Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors

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12 December 2020

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors

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12 December 2020

The GABA(B) receptor antagonist CGP36742 improves learned helplessness in rats.

1 reference

12 December 2020

CGP 36742: the first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

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12 December 2020

International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function

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12 December 2020

Increased sensitivity to the antinociceptive activity of (+/-)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia

1 reference

12 December 2020

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor

1 reference

12 December 2020

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

1 reference

12 December 2020

The metabotropic glutamate receptors: structure, activation mechanism and pharmacology

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12 December 2020

Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain

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12 December 2020

No ligand binding in the GB2 subunit of the GABA(B) receptor is required for activation and allosteric interaction between the subunits.

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12 December 2020

Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins

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12 December 2020

Antitussive effect of the GABA-agonist baclofen

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12 December 2020

Cloning and functional expression of GABA(B) receptors from Drosophila

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12 December 2020

GABAB receptor antagonists: potential new anti-absence drugs

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12 December 2020

(-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor.

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12 December 2020

GABAB receptors - the first 7TM heterodimers.

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12 December 2020

GABA(B)-receptor isoforms molecular architecture and distribution

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12 December 2020

G16 as a universal G protein adapter: implications for agonist screening strategies.

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12 December 2020

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12 December 2020

Effects of gamma-aminobutyrate B receptor modulation on normal micturition and oxyhemoglobin induced detrusor overactivity in female rats

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12 December 2020

Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors

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12 December 2020

Cocaine alters GABA(B)-mediated G-protein activation in the ventral tegmental area of female rats: modulation by estrogen

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12 December 2020

C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

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12 December 2020

Comparative immunohistochemical localisation of GABA(B1a), GABA(B1b) and GABA(B2) subunits in rat brain, spinal cord and dorsal root ganglion

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12 December 2020

Effects of positive allosteric modulators of the GABAB receptor on cocaine self-administration in rats

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12 December 2020

Association of GABA(B) receptors and members of the 14-3-3 family of signaling proteins

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12 December 2020

Drug-like properties and the causes of poor solubility and poor permeability

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12 December 2020

GABAB-receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization.

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12 December 2020

Identifiers

DOI

10.1385/JMN:26:2-3:169

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Dimensions Publication ID

12 August 2017

1018463503

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