(Q36201740)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer (English)

1 reference

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5 February 2020

0 references

8

1 reference

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5 February 2020

Ana Carolina Stumbo

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Yraima Cordeiro

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Jerson Lima

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

Guilherme A P de Oliveira

5 February 2020

0 references

author name string

Ana P D Ano Bom

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Luciana P Rangel

2

1 reference

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5 February 2020

Danielly C F Costa

3

1 reference

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5 February 2020

Guilherme A P de Oliveira

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Daniel Sanches

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Carolina A Braga

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Lisandra M Gava

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Ana O T Cepeda

9

1 reference

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5 February 2020

Claudia V De Moura Gallo

11

1 reference

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5 February 2020

language of work or name

English

0 references

publication date

19 June 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

5 February 2020

published in

1 reference

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5 February 2020

volume

287

1 reference

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5 February 2020

issue

33

1 reference

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5 February 2020

page(s)

28152-28162

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

The two faces of Janus: functional interactions and protein aggregation

5 February 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Potential roles for prions and protein-only inheritance in cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The client protein p53 adopts a molten globule-like state in the presence of Hsp90.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The role of mutant p53 in human cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

TP53 mutations in human cancers: origins, consequences, and clinical use

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The transcellular spread of cytosolic amyloids, prions, and prionoids

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Prion-like mechanisms in neurodegenerative diseases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The p53 core domain is a molten globule at low pH: functional implications of a partially unfolded structure.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Ligand binding and hydration in protein misfolding: insights from studies of prion and p53 tumor suppressor proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Structural evolution of p53, p63, and p73: Implication for heterotetramer formation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The peculiar interaction between mammalian prion protein and RNA

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Structural biology of the tumor suppressor p53.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The (1-63) region of the p53 transactivation domain aggregates in vitro into cytotoxic amyloid assemblies.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

p53 in health and disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Prions and transmissible spongiform encephalopathy (TSE) chemotherapeutics: A common mechanism for anti-TSE compounds?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Protein misfolding, functional amyloid, and human disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Potent antiscrapie activities of degenerate phosphorothioate oligonucleotides

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Unfolding, aggregation, and amyloid formation by the tetramerization domain from mutant p53 associated with lung cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Disruption of an intermonomer salt bridge in the p53 tetramerization domain results in an increased propensity to form amyloid fibrils.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The amino-terminal PrP domain is crucial to modulate prion misfolding and aggregation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Conformation-dependent antibodies target diseases of protein misfolding

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Reversible aggregation plays a crucial role on the folding landscape of p53 core domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Assessing TP53 status in human tumours to evaluate clinical outcome

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Biogenesis of p53 involves cotranslational dimerization of monomers and posttranslational dimerization of dimers. Implications on the dominant negative effect

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Molecular biology. Getting p53 out of the nucleus.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

p53 mutations in human cancers

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Cognate DNA stabilizes the tumor suppressor p53 and prevents misfolding and aggregation.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Physical basis of colors seen in Congo red-stained amyloid in polarized light.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Hydration and packing effects on prion folding and beta-sheet conversion. High pressure spectroscopy and pressure perturbation calorimetry studies.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Fibrillar aggregates of the tumor suppressor p53 core domain

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Structure, function, and aggregation of the zinc-free form of the p53 DNA binding domain

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3431633

Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors

22 September 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.340638

Heparin Binding by Murine Recombinant Prion Protein Leads to Transient Aggregation and Formation of RNA-Resistant Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.340638

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.340638

Amyloid Fibrils of Mammalian Prion Protein Are Highly Toxic to Cultured Cells and Primary Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.340638

p53 protein accumulation detected by five different antibodies: relationship to prognosis and heat shock protein 70 in breast cancer

21 January 2018

1 reference

12 December 2020

Role of p53 alteration in primary peritoneal carcinoma

1 reference

12 December 2020

Tumor pH: implications for treatment and novel drug design

1 reference

12 December 2020

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.340638

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22715097%20AND%20SRC:MED&resulttype=core&format=json