(Q36205826)

12 August 2017

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title

Leukotriene modifiers as potential therapeutics for cardiovascular disease (English)

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12 August 2017

cardiovascular disease

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Colin D Funk

1

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12 August 2017

1 August 2005

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Nature Reviews Drug Discovery

12 August 2017

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12 August 2017

4

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12 August 2017

8

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12 August 2017

664-672

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https://scigraph.springernature.com/pub.10.1038/nrd1796

12 August 2017

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cites work

Leukotrienes: Mediators of Immediate Hypersensitivity Reactions and Inflammation

1 reference

Prostaglandins and leukotrienes: advances in eicosanoid biology

31 March 2020

1 reference

Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases

31 March 2020

1 reference

The role of leukotrienes in inflammation

31 March 2020

1 reference

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

31 March 2020

1 reference

A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders

31 March 2020

1 reference

Characterization of the human cysteinyl leukotriene CysLT1 receptor

31 March 2020

1 reference

Characterization of the human cysteinyl leukotriene 2 receptor

31 March 2020

1 reference

Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis

31 March 2020

1 reference

Identification and isolation of a membrane protein necessary for leukotriene production

31 March 2020

1 reference

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

31 March 2020

1 reference

Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells

31 March 2020

1 reference

Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues.

31 March 2020

1 reference

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

31 March 2020

1 reference

Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment

31 March 2020

1 reference

Leukotriene C: a slow-reacting substance from murine mastocytoma cells

31 March 2020

1 reference

Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response

31 March 2020

1 reference

Leukotrienes are potent constrictors of human bronchi

31 March 2020

1 reference

The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes

31 March 2020

1 reference

Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow

31 March 2020

1 reference

The release of histamine and formation of a slow-reacting substance (SRS-A) during anaphylactic shock

31 March 2020

1 reference

Effect of a 5-lipoxygenase inhibitor on leukotriene generation and airway responses after allergen challenge in asthmatic patients

31 March 2020

1 reference

Biochemistry and physiology of the leukotrienes

31 March 2020

1 reference

A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model

31 March 2020

1 reference

Antileukotrienes in the treatment of asthma

31 March 2020

1 reference

31 March 2020

Leukotriene modifiers.

1 reference

Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis

31 March 2020

1 reference

Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis

31 March 2020

1 reference

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke

31 March 2020

1 reference

On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors

31 March 2020

1 reference

Reduced Allergen-Induced Nasal Congestion and Leukotriene Synthesis with an Orally Active 5-Lipoxygenase Inhibitor

31 March 2020

1 reference

The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air

31 March 2020

1 reference

The discovery and development of zileuton: An orally active 5-lipoxygenase inhibitor

31 March 2020

1 reference

Pharmacological profile of AA-861, A 5-lipoxygenase inhibitor

31 March 2020

1 reference

Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma

31 March 2020

1 reference

Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors

31 March 2020

1 reference

Role of leukotrienes in antimicrobial host defense of the lung

31 March 2020

1 reference

Leukotrienes: underappreciated mediators of innate immune responses

31 March 2020

1 reference

The effect of MK-0591, a novel 5-lipoxygenase activating protein inhibitor, on leukotriene biosynthesis and allergen-induced airway responses in asthmatic subjects in vivo

31 March 2020

1 reference

Pranlukast: a review of its use in the management of asthma

31 March 2020

1 reference

Pranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma

31 March 2020

1 reference

The emerging role of leukotriene modifiers in allergic rhinitis

31 March 2020

1 reference

FDA approves zafirlukast, first of new type of asthma drug

31 March 2020

1 reference

Montelukast, a leukotriene-receptor antagonist, for the treatment of mild asthma and exercise-induced bronchoconstriction

31 March 2020

1 reference

Immunopathogenetic roles of leukotrienes in human diseases

31 March 2020

1 reference

Leukotriene involvement in pathologic processes

31 March 2020

1 reference

Leukotrienes in ulcerative colitis: results of a multicenter trial of a leukotriene biosynthesis inhibitor, MK-591.

31 March 2020

1 reference

Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro

31 March 2020

1 reference

Leukotriene C4 affects pulmonary and cardiovascular dynamics in monkey

31 March 2020

1 reference

Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction

31 March 2020

1 reference

Leukotrienes and the cardiovascular system

31 March 2020

1 reference

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts

31 March 2020

1 reference

Colocalization of 15-lipoxygenase mRNA and protein with epitopes of oxidized low density lipoprotein in macrophage-rich areas of atherosclerotic lesions

31 March 2020

1 reference

Involvement of 15-lipoxygenase in early stages of atherogenesis

31 March 2020

1 reference

Lipoxygenase contributes to the oxidation of lipids in human atherosclerotic plaques

31 March 2020

1 reference

Disruption of the 12/15-lipoxygenase gene diminishes atherosclerosis in apo E-deficient mice

31 March 2020

1 reference

At last, direct evidence that lipoxygenases play a role in atherogenesis

31 March 2020

1 reference

Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice

31 March 2020

1 reference

12/15-Lipoxygenase gene disruption attenuates atherogenesis in LDL receptor-deficient mice

31 March 2020

1 reference

Selective interleukin-12 synthesis defect in 12/15-lipoxygenase-deficient macrophages associated with reduced atherosclerosis in a mouse model of familial hypercholesterolemia

31 March 2020

1 reference

Critical role of macrophage 12/15-lipoxygenase for atherosclerosis in apolipoprotein E-deficient mice

31 March 2020

1 reference

Characterization of the human 5-lipoxygenase gene

31 March 2020

1 reference

Characterization of the human 5-lipoxygenase gene promoter

31 March 2020

1 reference

Naturally occurring mutations in the human 5-lipoxygenase gene promoter that modify transcription factor binding and reporter gene transcription

31 March 2020

1 reference

Genetic variations in the 5-lipoxygenase core promoter. Description and functional implications

31 March 2020

1 reference

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

31 March 2020

1 reference

Egr-1 and Sp1 interact functionally with the 5-lipoxygenase promoter and its naturally occurring mutants

31 March 2020

1 reference

Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population

31 March 2020

1 reference

ALOX5AP gene and the PDE4D gene in a central European population of stroke patients

31 March 2020

1 reference

Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice

31 March 2020

1 reference

Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice

31 March 2020

1 reference

The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.

31 March 2020

1 reference

Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms

31 March 2020

1 reference

Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia

31 March 2020

1 reference

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model

31 March 2020

1 reference

Amino acid differences in the deduced 5-lipoxygenase sequence of CAST atherosclerosis-resistance mice confer impaired activity when introduced into the human ortholog.

31 March 2020

1 reference

5-Lipoxygenase and atherosclerosis

31 March 2020

1 reference

Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: a randomized trial

31 March 2020

1 reference

Prognostic value of myeloperoxidase in patients with chest pain

31 March 2020

1 reference

Activation of the human neutrophil 5-lipoxygenase by leukotriene B4

31 March 2020

1 reference

Autocrine enhancement of leukotriene synthesis by endogenous leukotriene B4 and platelet-activating factor in human neutrophils

31 March 2020

1 reference

Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime

31 March 2020

1 reference

Atherosclerosis — An Inflammatory Disease

31 March 2020

1 reference

Inflammation in atherosclerosis

31 March 2020

1 reference

Inflammation, atherosclerosis, and coronary artery disease

31 March 2020

1 reference

Association between 5-lipoxygenase expression and plaque instability in humans

31 March 2020

1 reference

Increased urinary leukotriene excretion in patients with cardiac ischemia. In vivo evidence for 5-lipoxygenase activation

31 March 2020

1 reference

Glutathione peroxidase-1 but not -4 is involved in the regulation of cellular 5-lipoxygenase activity in monocytic cells

31 March 2020

1 reference

Glutathione Peroxidase 1 Activity and Cardiovascular Events in Patients with Coronary Artery Disease

31 March 2020

1 reference

Heart disease. Gene suggests asthma drugs may ease cardiovascular inflammation

31 March 2020

1 reference

Aneurysms: leukotrienes weaken aorta from the outside

31 March 2020

1 reference

L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

The potential role of antileukotriene drugs in atherosclerosis

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1796

1 reference

12 August 2017

1 reference

PubMed ID

16041318