(Q36215905)

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A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics.

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778266%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

A novel mechanism involving four-and-a-half LIM domain protein-1 and extracellular signal-regulated kinase-2 regulates titin phosphorylation and mechanics (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778266%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

phosphorylation

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2

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7 February 2020

author name string

Anna Raskin

1

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7 February 2020

Katherine Banares

3

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7 February 2020

Robert C Lyon

4

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7 February 2020

Anke Zieseniss

5

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7 February 2020

Leonard K Lee

6

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7 February 2020

Katrina G Yamazaki

7

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7 February 2020

Henk L Granzier

8

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7 February 2020

Carol C Gregorio

9

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7 February 2020

Andrew D McCulloch

10

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7 February 2020

Jeffrey H Omens

11

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7 February 2020

Farah Sheikh

12

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7 February 2020

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publication date

9 July 2012

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7 February 2020

number of pages

12

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Journal of Biological Chemistry

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7 February 2020

287

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7 February 2020

35

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7 February 2020

29273-29284

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7 February 2020

describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3436149/fullTextXML

based on heuristic

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Truncations of titin causing dilated cardiomyopathy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Acceleration of crossbridge kinetics by protein kinase A phosphorylation of cardiac myosin binding protein C modulates cardiac function.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Cardiac titin: structure, functions and role in disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Phosphorylation of titin modulates passive stiffness of cardiac muscle in a titin isoform-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

The LIM domain: from the cytoskeleton to the nucleus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Subcellular targeting of metabolic enzymes to titin in heart muscle may be mediated by DRAL/FHL-2

1 reference

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1 October 2017

Involvement of extracellular signal-regulated kinases 1/2 in cardiac hypertrophy and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Diastolic heart failure: restrictive cardiomyopathy, constrictive pericarditis, and cardiac tamponade: clinical and echocardiographic evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Titin mutations as the molecular basis for dilated cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

LV hypertrophy and diastolic heart failure.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Identification of differentially expressed genes in cardiac hypertrophy by analysis of expressed sequence tags

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

The LIM domain: regulation by association

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Mechanical stretch rapidly activates multiple signal transduction pathways in cardiac myocytes: potential involvement of an autocrine/paracrine mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

The LIM domain is a modular protein-binding interface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Titins: giant proteins in charge of muscle ultrastructure and elasticity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

1 October 2017

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

29 June 2018

Protein kinase-A phosphorylates titin in human heart muscle and reduces myofibrillar passive tension

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

29 June 2018

Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

29 June 2018

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Abnormal cardiac wall motion and early matrix metalloproteinase activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Titin isoforms in heart failure: are there benefits to supersizing?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Myocardial collagen turnover in hypertrophic cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Titin isoform expression in normal and hypertensive myocardium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Titin isoform switch in ischemic human heart disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Protein kinase A phosphorylates titin's cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436149

22 September 2018

Separation of a phosphorylated histidine protein using phosphate affinity polyacrylamide gel electrophoresis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Focus issue: recruiting players for a game of ERK

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential expression of cardiac titin isoforms and modulation of cellular stiffness

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation of phospholamban and troponin I in beta-adrenergic-induced acceleration of cardiac relaxation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanical stretch activates the stress-activated protein kinases in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular aspects of mechanical stress-induced cardiac hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanically driven contour-length adjustment in rat cardiac titin's unique N2B sequence: titin is an adjustable spring.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiomyocyte Stiffness in Diastolic Heart Failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional analysis of titin/connectin N2-B mutations found in cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22778266

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.372839

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778266%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778266%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22778266%20AND%20SRC:MED&resulttype=core&format=json

7 February 2020

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