(Q36217394)

12 August 2017

Methionine oxidation perturbs the structural core of the prion protein and suggests a generic misfolding pathway (English)

1 reference

12 August 2017

0 references

Nadine D Younan

1

1 reference

12 August 2017

Rebecca C Nadal

2

1 reference

12 August 2017

Paul Davies

3

1 reference

12 August 2017

David R Brown

4

1 reference

12 August 2017

John H Viles

5

1 reference

12 August 2017

language of work or name

English

0 references

publication date

31 May 2012

1 reference

Journal of Biological Chemistry

12 August 2017

1 reference

12 August 2017

287

1 reference

12 August 2017

34

1 reference

12 August 2017

28263-28275

1 reference

Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper redox cycling in the prion protein depends critically on binding mode

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Oxidation of Helix-3 methionines precedes the formation of PK resistant PrP.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Methionine sulfoxides on prion protein Helix-3 switch on the alpha-fold destabilization required for conversion.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper and the structural biology of the prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Prion protein amyloid formation under native-like conditions involves refolding of the C-terminal alpha-helical domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Genes contributing to prion pathogenesis

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Extrinsic fluorescent dyes as tools for protein characterization

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Methionine sulfoxide reductases: relevance to aging and protection against oxidative stress.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Neurodegeneration and oxidative stress: prion disease results from loss of antioxidant defence

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Reactive oxygen species-mediated beta-cleavage of the prion protein in the cellular response to oxidative stress

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Increased susceptibility to oxidative stress in scrapie-infected neuroblastoma cells is associated with intracellular iron status

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Methionine oxidation and aging

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper binding in the prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Cooperative interactions and a non-native buried Trp in the unfolded state of an SH3 domain

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Oxidative stress and neurodegeneration in prion diseases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Three-dimensional structures of prion proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper-catalyzed oxidation of the recombinant SHa(29-231) prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Prion infection impairs the cellular response to oxidative stress

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Prion disease: A loss of antioxidant function?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Evidence of presynaptic location and function of the prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper binding to the prion protein: structural implications of four identical cooperative binding sites

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Prion protein NMR structure and familial human spongiform encephalopathies

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

A scrapie-like unfolding intermediate of the prion protein domain PrP(121-231) induced by acidic pH.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

The cellular prion protein binds copper in vivo

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Structure of the recombinant full-length hamster prion protein PrP(29-231): the N terminus is highly flexible

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Methionine residues as endogenous antioxidants in proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

NMR structure of the mouse prion protein domain PrP(121-231)

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Oxygen toxicity, oxygen radicals, transition metals and disease

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Evidence for release of copper in the brain: depolarization-induced release of newly taken-up 67copper

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Nerve endings from rat brain tissue release copper upon depolarization. A possible role in regulating neuronal excitability

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Copper(II)-induced secondary structure changes and reduced folding stability of the prion protein

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Fragment length influences affinity for Cu2+ and Ni2+ binding to His96 or His111 of the prion protein and spectroscopic evidence for a multiple histidine binding only at low pH.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Fragmentation and dimerization of copper-loaded prion protein by copper-catalysed oxidation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Aggregation and fibrillization of the recombinant human prion protein huPrP90-231.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Coenzyme Q and protein/lipid oxidation in a BSE-infected transgenic mouse model.

29 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Oxidative stress in the brain at early preclinical stages of mouse scrapie.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Increased oxidation, glycoxidation, and lipoxidation of brain proteins in prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Oxidation, glycoxidation, lipoxidation, nitration, and responses to oxidative stress in the cerebral cortex in Creutzfeldt-Jakob disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Alteration of free radical metabolism in the brain of mice infected with scrapie agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Methionine sulfoxides on PrPSc: a prion-specific covalent signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Structural characterization of beta-sheeted oligomers formed on the pathway of oxidative prion protein aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Methionine oxidation interferes with conversion of the prion protein into the fibrillar proteinase K-resistant conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Substoichiometric levels of Cu2+ ions accelerate the kinetics of fiber formation and promote cell toxicity of amyloid-{beta} from Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Oxidation of methionine residues in the prion protein by hydrogen peroxide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Copper chelation delays the onset of prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Amyloid beta-Cu2+ complexes in both monomeric and fibrillar forms do not generate H2O2 catalytically but quench hydroxyl radicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Hydrogen peroxide cleavage of the prion protein generates a fragment able to initiate polymerisation of full length prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Local structural plasticity of the prion protein. Analysis of NMR relaxation dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Dynamics of a truncated prion protein, PrP(113-231), from (15)N NMR relaxation: order parameters calculated and slow conformational fluctuations localized to a distinct region

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Deconvoluting the Cu2+ binding modes of full-length prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Evaluation of copper2+ affinities for the prion protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Probing copper2+ binding to the prion protein using diamagnetic nickel2+ and 1H NMR: the unstructured N terminus facilitates the coordination of six copper2+ ions at physiological concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Folding of prion protein to its native alpha-helical conformation is under kinetic control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

On the mechanism of alpha-helix to beta-sheet transition in the recombinant prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Detailed biophysical characterization of the acid-induced PrP(c) to PrP(β) conversion process.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

NMR characterization of the pH 4 beta-intermediate of the prion protein: the N-terminal half of the protein remains unstructured and retains a high degree of flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Conformational pH dependence of intermediate states during oligomerization of the human prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Identification by NMR of the binding surface for the histidine-containing phosphocarrier protein HPr on the N-terminal domain of enzyme I of the Escherichia coli phosphotransferase system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Folding intermediates of the prion protein stabilized by hydrostatic pressure and low temperature

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Imbalance of antioxidant defense in mice lacking cellular prion protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Methionine-oxidized amyloid fibrils are poor substrates for human methionine sulfoxide reductases A and B2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Certain Metals Trigger Fibrillation of Methionine-oxidized α-Synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

A manganese-superoxide dismutase/catalase mimetic extends survival in a mouse model of human prion disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M112.354779

The cellular prion protein binds copper in vivo

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3436581

Oxidative stress and the prion protein in transmissible spongiform encephalopathies

22 September 2018

1 reference

12 December 2020

pH-dependent stability and conformation of the recombinant human prion protein PrP(90-231)

1 reference

12 December 2020

Extremely rapid folding of the C-terminal domain of the prion protein without kinetic intermediates

1 reference

12 December 2020

Selective oxidation of methionine residues in prion proteins

1 reference

12 December 2020

Protein oxidation and aging

1 reference

12 December 2020

Prion protein does not redox-silence Cu2+, but is a sacrificial quencher of hydroxyl radicals

1 reference

12 December 2020

Oligomerization of the human prion protein proceeds via a molten globule intermediate

1 reference

12 December 2020

Empirical rules for rationalising visible circular dichroism of Cu2+ and Ni2+ histidine complexes: applications to the prion protein

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M112.354779

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

22654104

1 reference