(Q36232552)

12 August 2017

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title

NUP98 fusion in human leukemia: dysregulation of the nuclear pore and homeodomain proteins (English)

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12 August 2017

Takuro Nakamura

1

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12 August 2017

publication date

1 July 2005

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International Journal of Hematology

12 August 2017

published in

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12 August 2017

volume

82

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12 August 2017

issue

1

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12 August 2017

page(s)

21-27

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The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA

12 August 2017

cites work

1 reference

Crossref

https://api.crossref.org/works/10.1532%2FIJH97.04160

NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15).

21 January 2018

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12 December 2020

Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopy.

1 reference

12 December 2020

NUP98 is fused to the NSD3 gene in acute myeloid leukemia associated with t(8;11)(p11.2;p15).

1 reference

12 December 2020

Retroviral insertional mutagenesis: tagging cancer pathways

1 reference

12 December 2020

NUP98 is fused to adducin 3 in a patient with T-cell acute lymphoblastic leukemia and myeloid markers, with a new translocation t(10;11)(q25;p15).

1 reference

12 December 2020

Pores for thought: nuclear pore complex proteins

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12 December 2020

Dynein and dynein-related genes

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12 December 2020

NUP98-HOXD13 gene fusion in therapy-related acute myelogenous leukemia.

1 reference

12 December 2020

Lineage-specific regulation of hematopoiesis by HOX-B8 (HOX-2.4): inhibition of granulocytic differentiation and potentiation of monocytic differentiation.

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12 December 2020

Proteomic analysis of the mammalian nuclear pore complex

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12 December 2020

Running on Ran: nuclear transport and the mitotic spindle.

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12 December 2020

Novel NUP98-HOXC11 fusion gene resulted from a chromosomal break within exon 1 of HOXC11 in acute myeloid leukemia with t(11;12)(p15;q13)

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12 December 2020

RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicase

1 reference

12 December 2020

HoxB4 confers definitive lymphoid-myeloid engraftment potential on embryonic stem cell and yolk sac hematopoietic progenitors.

1 reference

12 December 2020

RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains

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12 December 2020

New genes involved in cancer identified by retroviral tagging

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12 December 2020

Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo

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12 December 2020

Homeobox genes in hematopoiesis

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12 December 2020

The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88

1 reference

12 December 2020

The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR.

1 reference

12 December 2020

The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

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12 December 2020

Oncogenic interaction between BCR-ABL and NUP98-HOXA9 demonstrated by the use of an in vitro purging culture system.

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12 December 2020

NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia

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12 December 2020

The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export

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12 December 2020

Early myeloid cell-specific expression of the human cathepsin G gene in transgenic mice

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12 December 2020

Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t(7;11)(p15;p15) in human myeloid leukaemia

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12 December 2020

The role of HOX homeobox genes in normal and leukemic hematopoiesis

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12 December 2020

Complex formation among the RNA export proteins Nup98, Rae1/Gle2, and TAP

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12 December 2020

Oncogenic transcription factors in the human acute leukemias

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12 December 2020

Inhibition of myeloid differentiation by Hoxa9, Hoxb8, and Meis homeobox genes

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12 December 2020

Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis.

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12 December 2020

Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

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12 December 2020

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export

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12 December 2020

Differential and common leukemogenic potentials of multiple NUP98-Hox fusion proteins alone or with Meis1

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12 December 2020

The (4;11)(q21;p15) translocation fuses the NUP98 and RAP1GDS1 genes and is recurrent in T-cell acute lymphocytic leukemia

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12 December 2020

A novel gene, NSD1, is fused to NUP98 in the t(5;11)(q35;p15.5) in de novo childhood acute myeloid leukemia.

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12 December 2020

The yeast nuclear pore complex: composition, architecture, and transport mechanism

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12 December 2020

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

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12 December 2020

The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells

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12 December 2020

The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex

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12 December 2020

A class act: conservation of homeodomain protein functions

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12 December 2020

Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes

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12 December 2020

Transport of proteins and RNAs in and out of the nucleus

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12 December 2020

Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function

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12 December 2020

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

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12 December 2020

The t(11;20)(p15;q11) chromosomal translocation associated with therapy-related myelodysplastic syndrome results in an NUP98-TOP1 fusion

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12 December 2020

Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation

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12 December 2020

The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex

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12 December 2020

Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket

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12 December 2020

Reconstituted nuclei depleted of a vertebrate GLFG nuclear pore protein, p97, import but are defective in nuclear growth and replication

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12 December 2020

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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12 December 2020

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

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12 December 2020

Recurrent coiled-coil motifs in NUP98 fusion partners provide a clue to leukemogenesis

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12 December 2020

CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity

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12 December 2020

A conserved biogenesis pathway for nucleoporins: proteolytic processing of a 186-kilodalton precursor generates Nup98 and the novel nucleoporin, Nup96

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12 December 2020

Nucleoporins nup98 and nup214 participate in nuclear export of human immunodeficiency virus type 1 Rev

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12 December 2020

Leukaemia disease genes: large-scale cloning and pathway predictions

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12 December 2020

Nuclear transport and cancer: from mechanism to intervention

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12 December 2020

A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

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12 December 2020

NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation

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12 December 2020

Nup98 is a mobile nucleoporin with transcription-dependent dynamics

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12 December 2020

Fusion of the NUP98 gene and the homeobox gene HOXC13 in acute myeloid leukemia with t(11;12)(p15;q13).

1 reference

12 December 2020

Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15).

1 reference

12 December 2020

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

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12 December 2020

t(9;11)(p22;p15) in acute myeloid leukemia results in a fusion between NUP98 and the gene encoding transcriptional coactivators p52 and p75-lens epithelium-derived growth factor (LEDGF).

1 reference

12 December 2020

Altered myeloid development and acute leukemia in transgenic mice expressing PML-RAR alpha under control of cathepsin G regulatory sequences

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12 December 2020

Ecotropic murine leukemia virus DNA content of normal and lymphomatous tissues of BXH-2 recombinant inbred mice

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12 December 2020

Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)

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12 December 2020

Nup98 localizes to both nuclear and cytoplasmic sides of the nuclear pore and binds to two distinct nucleoporin subcomplexes

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12 December 2020

NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice

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12 December 2020

The inv(11)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene, DDX10

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12 December 2020

Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation

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12 December 2020

Origins of chromosome translocations in childhood leukaemia

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12 December 2020

The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15).

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12 December 2020

Autoproteolysis in nucleoporin biogenesis

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12 December 2020

Checklist: vertebrate homeobox genes

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12 December 2020

Identifiers

DOI

10.1532/IJH97.04160

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Dimensions Publication ID

12 August 2017

1042982765

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