(Q36243062)

13 August 2017

From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules (English)

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13 August 2017

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Tamer S Kaoud

1

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13 August 2017

Chunli Yan

2

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13 August 2017

Shreya Mitra

3

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13 August 2017

Chun-Chia Tseng

4

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13 August 2017

Jiney Jose

5

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13 August 2017

Juliana M Taliaferro

6

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13 August 2017

Maidina Tuohetahuntila

7

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13 August 2017

Ashwini Devkota

8

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13 August 2017

Rachel Sammons

9

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13 August 2017

Jihyun Park

10

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13 August 2017

Heekwang Park

11

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13 August 2017

Yue Shi

12

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13 August 2017

Jiyong Hong

13

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13 August 2017

Pengyu Ren

14

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13 August 2017

Kevin N Dalby

15

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13 August 2017

language of work or name

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1 August 2012

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ACS Medicinal Chemistry Letters

13 August 2017

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13 August 2017

3

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13 August 2017

9

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13 August 2017

721-725

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Computational insights for the discovery of non-ATP competitive inhibitors of MAP kinases

13 August 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Nonvisual arrestins function as simple scaffolds assembling the MKK4-JNK3α2 signaling complex

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Development of JNK2-selective peptide inhibitors that inhibit breast cancer cell migration

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

c-Jun N-terminal kinase 2 (JNK2) enhances cell migration through epidermal growth factor substrate 8 (EPS8).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

The alpha-kinase family: an exceptional branch on the protein kinase tree.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Discovery of 2-(5-nitrothiazol-2-ylthio)benzo[d]thiazoles as novel c-Jun N-terminal kinase inhibitors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Protocol for MM/PBSA molecular dynamics simulations of proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Targeting JNK for therapeutic benefit: from junk to gold?

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs).

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

The JIP group of mitogen-activated protein kinase scaffold proteins

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Synthesis and optimization of thiadiazole derivatives as a novel class of substrate competitive c-Jun N-terminal kinase inhibitors

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Comparison of the NCI open database with seven large chemical structural databases.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Small molecule JNK (c-Jun N-terminal kinase) inhibitors.

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Design, synthesis, and structure-activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Identification of small-molecule inhibitors of the JIP-JNK interaction.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated k

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

Therapeutic promise of JNK ATP-noncompetitive inhibitors.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3445420

22 September 2018

Identifiers

DOI

10.1021/ML300129B

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13 August 2017

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13 August 2017

PubMed publication ID

23002419

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