(Q36249887)

13 August 2017

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title

The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents (English)

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13 August 2017

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Paul M O'Neill

1

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13 August 2017

language of work or name

English

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publication date

1 September 2005

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Expert Opinion on Investigational Drugs

13 August 2017

published in

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13 August 2017

volume

14

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13 August 2017

issue

9

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13 August 2017

page(s)

1117-1128

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Qinghaosu (artemisinin): an antimalarial drug from China

13 August 2017

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1 reference

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Artesunate. A review of its pharmacology and therapeutic efficacy in the treatment of malaria

21 January 2018

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Estimating the needs for artesunate-based combination therapy for malaria case-management in Africa

21 January 2018

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Combination therapy for malaria: the way forward?

21 January 2018

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Haemozoin and the mode of action of blood schizontocides: more controversy

21 January 2018

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Artemisinin (qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action

21 January 2018

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A medicinal chemistry perspective on artemisinin and related endoperoxides

21 January 2018

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The interaction of artemisinin with malarial hemozoin

21 January 2018

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Reaction of antimalarial endoperoxides with specific parasite proteins

21 January 2018

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Hemozoin formation in malaria: a two-step process involving histidine-rich proteins and lipids

21 January 2018

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Possible modes of action of the artemisinin-type compounds.

21 January 2018

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Radical mechanism of action of the artemisinin-type compounds

21 January 2018

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How might qinghaosu (artemisinin) and related compounds kill the intraerythrocytic malaria parasite? A chemist's view

21 January 2018

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Characterization of the Alkylation Product of Heme by the Antimalarial Drug Artemisinin We are grateful to the CNRS for financial support, and to the French Ministery of Education for a PhD grant to J.C. Dr. Yannick Coppel (LCC-CNRS) is gratefully a

21 January 2018

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Three-dimensional structure of Plasmodium falciparum Ca2+ -ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6.

21 January 2018

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From mechanistic studies on artemisinin derivatives to new modular antimalarial drugs

21 January 2018

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Artemisinins: mechanisms of action and potential for resistance

21 January 2018

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Efficient preparations of the beta-glucuronides of dihydroartemisinin and structural confirmation of the human glucuronide metabolite

21 January 2018

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Glucuronidation of dihydroartemisinin in vivo and by human liver microsomes and expressed UDP-glucuronosyltransferases

21 January 2018

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Knowledge of the proposed chemical mechanism of action and cytochrome p450 metabolism of antimalarial trioxanes like artemisinin allows rational design of new antimalarial peroxides

21 January 2018

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Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria

21 January 2018

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Artemisinin and derivatives: the future for malaria treatment?

21 January 2018

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Neurotoxicity in animals due to arteether and artemether

21 January 2018

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Orally Active, Hydrolytically Stable, Semisynthetic, Antimalarial Trioxanes in the Artemisinin Family

21 January 2018

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Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers with high stability and efficacy

21 January 2018

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Mechanism-based design of parasite-targeted artemisinin derivatives: synthesis and antimalarial activity of new diamine containing analogues

21 January 2018

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Synthetic peroxides as antimalarials

21 January 2018

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A short synthesis and biological evaluation of potent and nontoxic antimalarial bridged bicyclic beta-sulfonyl-endoperoxides

21 January 2018

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Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.

21 January 2018

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Orally active, water-soluble antimalarial 3-aryltrioxanes: short synthesis and preclinical efficacy testing in rodents

21 January 2018

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Photo-oxygenation of geraniol: synthesis of a novel series of hydroxy-functionalized anti-malarial 1,2,4-trioxanes

21 January 2018

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Identification of an antimalarial synthetic trioxolane drug development candidate

21 January 2018

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Synthesis of tetrasubstituted ozonides by the Griesbaum coozonolysis reaction: diastereoselectivity and functional group transformations by post-ozonolysis reactions

21 January 2018

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Artemether-lumefantrine for the treatment of multidrug-resistant falciparum malaria

21 January 2018

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Antimalarial drug resistance and combination chemotherapy

21 January 2018

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Preventing antimalarial drug resistance through combinations

21 January 2018

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Efficacy and effectiveness of the combination of sulfadoxine/pyrimethamine and a 3-day course of artesunate for the treatment of uncomplicated falciparum malaria in a refugee settlement in Zambia

21 January 2018

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Piperaquine: a resurgent antimalarial drug.

21 January 2018

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Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria

21 January 2018

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Synthesis and antimalarial activity of a new series of trioxaquines

21 January 2018

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Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules

21 January 2018

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Antimalarial chemotherapeutic peroxides: artemisinin, yingzhaosu A and related compounds

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.14.9.1117

Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene.

21 January 2018

1 reference

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Methyl-Substituted Dispiro-1,2,4,5-tetraoxanes: Correlations of Structural Studies with Antimalarial Activity

21 January 2018

1 reference

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10.1517/13543784.14.9.1117

21 January 2018

Identifiers

DOI

1 reference

13 August 2017

1 reference