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Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE.
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PMCID
2132875
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3 December 2019
title
Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE
(English)
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Europe PubMed Central
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2132875
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3 December 2019
author
Tamara Darsow
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1
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2132875
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9722605%20AND%20SRC:MED&resulttype=core&format=json
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3 December 2019
Christopher G Burd
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2
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2132875
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3 December 2019
author name string
S D Emr
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3
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2132875
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3 December 2019
language of work or name
English
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publication date
1 August 1998
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3 December 2019
number of pages
10
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Journal of Cell Biology
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2132875
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3 December 2019
volume
142
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2132875
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3 December 2019
page(s)
913-922
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PMCID
2132875
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3 December 2019
issue
4
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2132875
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9722605%20AND%20SRC:MED&resulttype=core&format=json
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3 December 2019
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Vam7p, a SNAP-25-like molecule, and Vam3p, a syntaxin homolog, function together in yeast vacuolar protein trafficking
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A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole
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Dileucine-based sorting signals bind to the beta chain of AP-1 at a site distinct and regulated differently from the tyrosine-based motif-binding site
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A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3.
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The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole
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The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole.
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The membrane protein alkaline phosphatase is delivered to the vacuole by a route that is distinct from the VPS-dependent pathway.
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30 September 2017
A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole
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A novel Sec18p/NSF-dependent complex required for Golgi-to-endosome transport in yeast
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Endosomal transport function in yeast requires a novel AAA-type ATPase, Vps4p
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Characterization of the adaptor-related protein complex, AP-3
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30 September 2017
AP-3: an adaptor-like protein complex with ubiquitous expression
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Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast
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In vitro binding of clathrin adaptors to sorting signals correlates with endocytosis and basolateral sorting
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30 September 2017
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A role for acidic residues in di-leucine motif-based targeting to the endocytic pathway
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30 September 2017
Structure-activity relationship of the leucine-based sorting motifs in the cytosolic tail of the major histocompatibility complex-associated invariant chain
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30 September 2017
A new vital stain for visualizing vacuolar membrane dynamics and endocytosis in yeast
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30 September 2017
Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase
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NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor
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30 September 2017
A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains
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30 September 2017
Alternative pathways for the sorting of soluble vacuolar proteins in yeast: a vps35 null mutant missorts and secretes only a subset of vacuolar hydrolases
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Localization of Sed5, a putative vesicle targeting molecule, to the cis-Golgi network involves both its transmembrane and cytoplasmic domains
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30 September 2017
High expression of the yeast syntaxin-related Vam3 protein suppresses the protein transport defects of a pep12 null mutant.
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29 June 2018
Regulation and function of the CD3gamma DxxxLL motif: a binding site for adaptor protein-1 and adaptor protein-2 in vitro.
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29 June 2018
Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast
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29 June 2018
Protein sorting by tyrosine-based signals: adapting to the Ys and wherefores.
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22 September 2018
Mutations in the VPS45 gene, a SEC1 homologue, result in vacuolar protein sorting defects and accumulation of membrane vesicles
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2132875
retrieved
22 September 2018
Identifiers
DOI
10.1083/JCB.142.4.913
1 reference
stated in
Europe PubMed Central
PMCID
2132875
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9722605%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
PMCID
2132875
1 reference
stated in
Europe PubMed Central
PMCID
2132875
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9722605%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
PubMed ID
9722605
1 reference
stated in
Europe PubMed Central
PMCID
2132875
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9722605%20AND%20SRC:MED&resulttype=core&format=json
retrieved
3 December 2019
ResearchGate publication ID
277547517
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