(Q36267383)

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Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion.

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18 February 2020

Selective astrocytic endothelin-1 overexpression contributes to dementia associated with ischemic stroke by exaggerating astrocyte-derived amyloid secretion (English)

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18 February 2020

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18 February 2020

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18 February 2020

author name string

Victor K L Hung

1

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18 February 2020

Patrick K K Yeung

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18 February 2020

Angela K W Lai

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18 February 2020

Maggie C Y Ho

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18 February 2020

Amy C Y Lo

5

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18 February 2020

Stephen S M Chung

8

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18 February 2020

Chi W Cheung

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18 February 2020

Sookja K Chung

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18 February 2020

publication date

24 June 2015

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18 February 2020

Journal of Cerebral Blood Flow & Metabolism

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18 February 2020

35

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18 February 2020

10

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18 February 2020

1687-1696

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18 February 2020

Amyloid beta-peptide worsens cognitive impairment following cerebral ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

The neurovascular unit - concept review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Transient focal cerebral ischemia/reperfusion induces early and chronic axonal changes in rats: its importance for the risk of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Glial regulation of the cerebral microvasculature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Neurovascular mechanisms of Alzheimer's neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Neurovascular regulation in the normal brain and in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Superoxide free radical and intracellular calcium mediate A beta(1-42) induced endothelial toxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Developments of a water-maze procedure for studying spatial learning in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

30 September 2017

Brain infarction and the clinical expression of Alzheimer disease. The Nun Study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

29 June 2018

A new model of focal brain ischemia based on the intracerebral injection of endothelin-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

29 June 2018

Increased plasma endothelin-1 in acute ischemic stroke

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

29 June 2018

Dementia after stroke: Baseline frequency, risks, and clinical features in a hospitalized cohort

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

29 June 2018

Comorbid rat model of ischemia and β-amyloid toxicity: striatal and cortical degeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

The γ-secretase blocker DAPT reduces the permeability of the blood-brain barrier by decreasing the ubiquitination and degradation of occludin during permanent brain ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Targeted overexpression of endothelin-1 in astrocytes leads to more severe cytotoxic brain edema and higher mortality.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Plasma beta-amyloid 1-40 is associated with the diffuse small vessel disease subtype.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Cerebrovascular endothelin receptor upregulation in cerebral ischemia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Enhanced cell death in hippocampus and emergence of cognitive impairments following a localized mini-stroke in hippocampus if preceded by a previous episode of acute stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Progressive increase in infarct size, neuroinflammation, and cognitive deficits in the presence of high levels of amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Enhanced cell death and learning deficits after a mini-stroke in aged hippocampus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelin-1 overexpression leads to further water accumulation and brain edema after middle cerebral artery occlusion via aquaporin 4 expression in astrocytic end-feet.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Circulating beta amyloid protein is elevated in patients with acute ischemic stroke.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Astroglial expression of the beta-amyloid in ischemia-reperfusion brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Cortical expression of endothelin receptor subtypes A and B following middle cerebral artery occlusion in rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Expression and distribution of beta amyloid precursor protein and beta amyloid peptide in reactive astrocytes after transient middle cerebral artery occlusion.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelin-1 protects astrocytes from hypoxic/ischemic injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Role of endothelin-1 in astrocyte responses after acute brain damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

beta-Amyloid-mediated vasoactivity and vascular endothelial damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Astrocytes in Alzheimer's disease express immunoreactivity to the vaso-constrictor endothelin-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4640314

22 September 2018

Cardiocirculatory arrest with hypothermia. Experimental study.

1 reference

https://api.crossref.org/works/10.1038%2FJCBFM.2015.109

21 January 2018

Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arachidonic acid release and permeability changes induced by endothelins in human cerebromicrovascular endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glial expression of the beta-amyloid precursor protein (APP) in global ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High serum levels of endothelin-1 predict severe cerebral edema in patients with acute ischemic stroke treated with t-PA

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta-amyloid-induced endothelial necrosis and inhibition of nitric oxide production

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of beta-amyloid precursor protein in reactive astrocytes following neuronal damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/26104290

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/JCBFM.2015.109

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26104290%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26104290%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26104290%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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