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The molecular biology of HIV integrase
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
title
The molecular biology of HIV integrase
(English)
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
main subject
HIV
0 references
molecular biology
1 reference
based on heuristic
inferred from title
author name string
Robert Craigie
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
language of work or name
English
1 reference
based on heuristic
inferred from title
publication date
1 July 2012
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
published in
Future Virology
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
volume
7
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
issue
7
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
page(s)
679-686
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
cites work
Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors
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Diketoacid inhibitors of HIV-1 integrase: from L-708,906 to raltegravir and beyond
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30 September 2017
DNA requirements for assembly and stability of HIV-1 intasomes
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30 September 2017
Modeling the HIV-1 Intasome: A Prototype View of the Target of Integrase Inhibitors
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30 September 2017
The HIV-1 integrase monomer induces a specific interaction with LTR DNA for concerted integration.
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30 September 2017
Inhibitors of the interactions between HIV-1 IN and the cofactor LEDGF/p75.
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The mechanism of retroviral integration from X-ray structures of its key intermediates
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Molecular mechanisms of retroviral integrase inhibition and the evolution of viral resistance.
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30 September 2017
Structure-based modeling of the functional HIV-1 intasome and its inhibition
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30 September 2017
High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region
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30 September 2017
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
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30 September 2017
Nucleoprotein intermediates in HIV-1 DNA integration visualized by atomic force microscopy
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Flexible use of nuclear import pathways by HIV-1.
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30 September 2017
Retroviral intasome assembly and inhibition of DNA strand transfer
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30 September 2017
Barrier-to-autointegration factor (BAF) condenses DNA by looping.
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PubMed Central
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30 September 2017
Piecing together the structure of retroviral integrase, an important target in AIDS therapy
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30 September 2017
The challenge of finding a cure for HIV infection
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30 September 2017
Mechanisms governing lentivirus integration site selection
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30 September 2017
Functional and structural characterization of the integrase from the prototype foamy virus
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30 September 2017
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Integrase, LEDGF/p75 and HIV replication
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
The road to chromatin - nuclear entry of retroviruses
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30 September 2017
An essential role for LEDGF/p75 in HIV integration
1 reference
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PubMed Central
reference URL
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30 September 2017
Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.
1 reference
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PubMed Central
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30 September 2017
A tripartite DNA-binding element, comprised of the nuclear localization signal and two AT-hook motifs, mediates the association of LEDGF/p75 with chromatin in vivo
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PubMed Central
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30 September 2017
Retroviral DNA integration: reaction pathway and critical intermediates
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30 September 2017
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
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PubMed Central
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30 September 2017
Intracytoplasmic maturation of the human immunodeficiency virus type 1 reverse transcription complexes determines their capacity to integrate into chromatin
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30 September 2017
Cellular co-factors of HIV-1 integration
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PubMed Central
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30 September 2017
Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.
1 reference
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PubMed Central
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30 September 2017
Genome-wide analysis of retroviral DNA integration
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Human cell proteins and human immunodeficiency virus DNA integration
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Structure and function of HIV-1 integrase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
HIV-1 integration in the human genome favors active genes and local hotspots
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PubMed Central
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30 September 2017
Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy
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PubMed Central
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30 September 2017
Efficient concerted integration by recombinant human immunodeficiency virus type 1 integrase without cellular or viral cofactors
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30 September 2017
HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase
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PubMed Central
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30 September 2017
Barrier-to-autointegration factor (BAF) bridges DNA in a discrete, higher-order nucleoprotein complex
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PubMed Central
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30 September 2017
Three-dimensional structure of the Tn5 synaptic complex transposition intermediate
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30 September 2017
A previously unidentified host protein protects retroviral DNA from autointegration
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PubMed Central
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30 September 2017
Solution structure of the N-terminal zinc binding domain of HIV-1 integrase
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PubMed Central
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30 September 2017
Human immunodeficiency virus type 1 preintegration complexes: studies of organization and composition
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30 September 2017
HIV-1 cDNA integration: requirement of HMG I(Y) protein for function of preintegration complexes in vitro
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30 September 2017
Concerted integration of linear retroviral DNA by the avian sarcoma virus integrase in vitro: dependence on both long terminal repeat termini
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PubMed Central
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30 September 2017
Protection of retroviral DNA from autointegration: involvement of a cellular factor
1 reference
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PubMed Central
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30 September 2017
Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases
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PubMed Central
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30 September 2017
Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection
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PubMed Central
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30 September 2017
Solution structure of the DNA binding domain of HIV-1 integrase
1 reference
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PubMed Central
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30 September 2017
HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase
1 reference
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PubMed Central
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30 September 2017
High-resolution structure of the catalytic domain of avian sarcoma virus integrase
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
The DNA-binding domain of HIV-1 integrase has an SH3-like fold
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Retroviral DNA integration: Structure of an integration intermediate
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PubMed Central
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30 September 2017
Correct integration of retroviral DNA in vitro
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PubMed Central
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30 September 2017
The avian retroviral integration protein cleaves the terminal sequences of linear viral DNA at the in vivo sites of integration
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PubMed Central
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30 September 2017
Retroviral integration: structure of the initial covalent product and its precursor, and a role for the viral IN protein
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PubMed Central
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30 September 2017
Integration of human immunodeficiency virus type 1 DNA in vitro
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PubMed Central
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30 September 2017
Human immunodeficiency virus integration in a cell-free system
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PubMed Central
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30 September 2017
Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex.
1 reference
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30 September 2017
DNA binding properties of the integrase proteins of human immunodeficiency viruses types 1 and 2
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Genetics of retroviral integration
1 reference
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PubMed Central
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30 September 2017
Mutational analysis of the integrase protein of human immunodeficiency virus type 2
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PubMed Central
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30 September 2017
Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Residues critical for retroviral integrative recombination in a region that is highly conserved among retroviral/retrotransposon integrases and bacterial insertion sequence transposases
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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30 September 2017
Recombinant human immunodeficiency virus type 1 integrase exhibits a capacity for full-site integration in vitro that is comparable to that of purified preintegration complexes from virus-infected cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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29 June 2018
Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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29 June 2018
A nucleoprotein complex mediates the integration of retroviral DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
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29 June 2018
The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
retrieved
29 June 2018
The IN protein of Moloney murine leukemia virus processes the viral DNA ends and accomplishes their integration in vitro
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3458710
retrieved
29 June 2018
Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
1 reference
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Crossref
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https://api.crossref.org/works/10.2217%2FFVL.12.56
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21 January 2018
Processing of viral DNA ends channels the HIV-1 integration reaction to concerted integration.
1 reference
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Crossref
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https://api.crossref.org/works/10.2217%2FFVL.12.56
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21 January 2018
Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor
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Crossref
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21 January 2018
Site-directed mutagenesis of HIV-1 integrase demonstrates differential effects on integrase functions in vitro
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PubMed Central
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22 September 2018
The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/23024700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Characterization of HIV replication complexes early after cell-to-cell infection
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23024700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
HIV-1 DNA integration: Mechanism of viral DNA cleavage and DNA strand transfer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/23024700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.2217/FVL.12.56
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
PMCID
3458710
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
PubMed ID
23024700
1 reference
stated in
Europe PubMed Central
PMCID
3458710
retrieved
13 August 2017
ResearchGate publication ID
231614320
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