(Q36287880)

13 August 2017

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title

Regulatory networks in embryo-derived pluripotent stem cells (English)

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13 August 2017

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Michele Boiani

1

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PubMed ID

16227977

13 August 2017

Hans R Schöler

series ordinal

2

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13 August 2017

1 November 2005

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Nature Reviews Molecular Cell Biology

13 August 2017

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13 August 2017

6

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13 August 2017

872-884

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13 August 2017

11

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https://scigraph.springernature.com/pub.10.1038/nrm1744

13 August 2017

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cites work

Stem cells from the Mammalian blastocyst

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Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells

31 March 2020

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Establishment in culture of pluripotential cells from mouse embryos

31 March 2020

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Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

31 March 2020

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Primate embryonic stem cells.

31 March 2020

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Embryonic stem cell lines derived from human blastocysts

31 March 2020

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Pluripotent stem cells--model of embryonic development, tool for gene targeting, and basis of cell therapy

31 March 2020

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Improved generation of germline-competent embryonic stem cell lines from inbred mouse strains

31 March 2020

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Single inner cell masses yield embryonic stem cell lines differing in lifr expression and their developmental potential.

31 March 2020

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Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei

31 March 2020

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Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.

31 March 2020

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RETRACTED: Evidence of a pluripotent human embryonic stem cell line derived from a cloned blastocyst

31 March 2020

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Embryonic stem cell differentiation: the role of extracellular factors

31 March 2020

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Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation

31 March 2020

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Molecular signature of human embryonic stem cells and its comparison with the mouse

31 March 2020

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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

31 March 2020

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Reflections on STAT3, STAT5, and STAT6 as fat STATs

31 March 2020

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Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

31 March 2020

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STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells

31 March 2020

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Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

31 March 2020

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Leukemia inhibitory factor-dependent transcriptional activation in embryonic stem cells

31 March 2020

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SOCS proteins: modulators of neuroimmunoendocrine functions. Impact on corticotroph LIF signaling.

31 March 2020

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Maintenance of pluripotency in human embryonic stem cells is STAT3 independent

31 March 2020

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Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

31 March 2020

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

31 March 2020

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Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse

31 March 2020

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BMPs signal alternately through a SMAD or FRAP-STAT pathway to regulate fate choice in CNS stem cells

31 March 2020

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Wnt signalling inhibits neural differentiation of embryonic stem cells by controlling bone morphogenetic protein expression

31 March 2020

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Wnt signaling: a common theme in animal development

31 March 2020

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Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation

31 March 2020

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The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway

31 March 2020

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Identification of c-MYC as a target of the APC pathway

31 March 2020

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Synthesis of the translational apparatus is regulated at the translational level

31 March 2020

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Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

31 March 2020

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Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation

31 March 2020

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mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells

31 March 2020

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Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development

31 March 2020

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Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E

31 March 2020

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Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production

31 March 2020

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Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis

31 March 2020

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Physiological functions of Pten in mouse tissues

31 March 2020

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PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

31 March 2020

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MicroRNAs: genomics, biogenesis, mechanism, and function

31 March 2020

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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

31 March 2020

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Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

31 March 2020

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"Stemness": transcriptional profiling of embryonic and adult stem cells

31 March 2020

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A stem cell molecular signature

31 March 2020

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A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

31 March 2020

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A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells

31 March 2020

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Turning germ cells into stem cells

31 March 2020

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Generation of pluripotent stem cells from neonatal mouse testis

31 March 2020

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Involvement of Oct3/4 in the enhancement of neuronal differentiation of ES cells in neurogenesis-inducing cultures

31 March 2020

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Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4

31 March 2020

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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells

31 March 2020

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Identification of putative downstream genes of Oct-4 by suppression-subtractive hybridization

31 March 2020

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Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor.

31 March 2020

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Sox genes find their feet

31 March 2020

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Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3

31 March 2020

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Multipotent cell lineages in early mouse development depend on SOX2 function

31 March 2020

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Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo

31 March 2020

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The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression.

31 March 2020

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A novel NK-type homeobox gene, ENK (early embryo specific NK), preferentially expressed in embryonic stem cells.

31 March 2020

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NK-2 homeobox genes and heart development

31 March 2020

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Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells

31 March 2020

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The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells

31 March 2020

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Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human

31 March 2020

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Pluripotential competence of cells associated with Nanog activity

31 March 2020

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Dppa3 is a marker of pluripotency and has a human homologue that is expressed in germ cell tumours.

31 March 2020

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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

31 March 2020

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Genetic control of susceptibility to spontaneous testicular germ cell tumors in mice

31 March 2020

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Regulation of PTEN transcription by p53

31 March 2020

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Forced expression of the homeobox-containing gene Pem blocks differentiation of embryonic stem cells

31 March 2020

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Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site

31 March 2020

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Interaction between a novel F9-specific factor and octamer-binding proteins is required for cell-type-restricted activity of the fibroblast growth factor 4 enhancer

31 March 2020

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The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2.

31 March 2020

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Identification of Sox-2 regulatory region which is under the control of Oct-3/4-Sox-2 complex

31 March 2020

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Mouse germline restriction of Oct4 expression by germ cell nuclear factor

31 March 2020

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Requirement for Wnt3 in vertebrate axis formation

31 March 2020

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Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes

31 March 2020

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Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

31 March 2020

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Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression

31 March 2020

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Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development

31 March 2020

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RETRACTED: Patient-specific embryonic stem cells derived from human SCNT blastocysts.

31 March 2020

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Correction of a genetic defect by nuclear transplantation and combined cell and gene therapy

31 March 2020

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Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice.

31 March 2020

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Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei.

31 March 2020

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Oct4 distribution and level in mouse clones: consequences for pluripotency

31 March 2020

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X-Chromosome inactivation in cloned mouse embryos.

31 March 2020

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Disruption of Imprinted Gene Methylation and Expression in Cloned Preimplantation Stage Mouse Embryos1

31 March 2020

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Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nuclei

31 March 2020

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Reversal of X-inactivation in female mouse somatic cells hybridized with murine teratocarcinoma stem cells in vitro

31 March 2020

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Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.

31 March 2020

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Cell fusion is the principal source of bone-marrow-derived hepatocytes

31 March 2020

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Transplanted bone marrow regenerates liver by cell fusion

31 March 2020

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Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion

31 March 2020

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Changing potency by spontaneous fusion.

31 March 2020

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Hematopoietic stem cells convert into liver cells within days without fusion.

31 March 2020

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Multipotent progenitor cells can be isolated from postnatal murine bone marrow, muscle, and brain.

31 March 2020

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31 March 2020

Altered nuclear transfer

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Altered nuclear transfer in stem-cell research - a flawed proposal.

31 March 2020

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Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation

31 March 2020

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Leukemia inhibitory factor (LIF) concentration modulates embryonic stem cell self-renewal and differentiation independently of proliferation

31 March 2020

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Multivariate proteomic analysis of murine embryonic stem cell self-renewal versus differentiation signaling

31 March 2020

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Mouse Chimaeras obtained by the Injection of Cells into the Blastocyst

31 March 2020

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Induced chimaerism by transplanting embryonic cells into mouse blastocysts

31 March 2020

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The effect of cells transferred into the mouse blastocyst on subsequent development

31 March 2020

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Normal genetically mosaic mice produced from malignant teratocarcinoma cells

31 March 2020

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Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts

31 March 2020

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Fate of teratocarcinoma cells injected into early mouse embryos

31 March 2020

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Chimaerism and erythroid marker expression after microinjection of human acute myeloid leukaemia cells into murine blastocysts

31 March 2020

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Alkaline Phosphatase Activity in Mouse Teratoma

31 March 2020

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METT-1: A karyotypically normal in vitro line of developmentally totipotent mouse teratocarcinoma cells

31 March 2020

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Embryonic stem cell lines derived from blastocysts by a simplified technique

31 March 2020

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Oct-4: gatekeeper in the beginnings of mammalian development.

31 March 2020

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New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2

31 March 2020

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Requirement of FGF-4 for postimplantation mouse development

31 March 2020

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New type of POU domain in germ line-specific protein Oct-4

31 March 2020

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Oct-4: a germline-specific transcription factor mapping to the mouse t-complex

31 March 2020

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Human embryonic stem cells assemble and fulfill their developmental destiny.

31 March 2020

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A germ cell origin of embryonic stem cells?

31 March 2020

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Derivation of oocytes from mouse embryonic stem cells

31 March 2020

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Embryonic stem cells can form germ cells in vitro

31 March 2020

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Derivation of embryonic germ cells and male gametes from embryonic stem cells.

31 March 2020

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Core transcriptional regulatory circuitry in human embryonic stem cells

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1744

1 reference

13 August 2017

1 reference

PubMed ID

16227977