(Q36293531)

13 August 2017

1 reference

title

The potential for molecular therapeutic targets in Ewing's sarcoma (English)

1 reference

13 August 2017

Nancy R McAllister

1

1 reference

PubMed ID

16242051

13 August 2017

Stephen L Lessnick

series ordinal

2

1 reference

PubMed ID

16242051

13 August 2017

language of work or name

1 reference

1 November 2005

1 reference

Current Treatment Options in Oncology

13 August 2017

1 reference

13 August 2017

6

1 reference

13 August 2017

6

1 reference

13 August 2017

461-471

1 reference

https://scigraph.springernature.com/pub.10.1007/s11864-005-0025-y

13 August 2017

0 references

cites work

The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1

1 reference

https://api.crossref.org/works/10.1007%2FS11864-005-0025-Y

Identification of target genes for the Ewing's sarcoma EWS/FLI fusion protein by representational difference analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11864-005-0025-Y

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11864-005-0025-Y

Potential use of imatinib in Ewing's Sarcoma: evidence for in vitro and in vivo activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11864-005-0025-Y

Engagement of CD99 induces apoptosis through a calcineurin-independent pathway in Ewing's sarcoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11864-005-0025-Y

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

21 January 2018

1 reference

12 December 2020

Treatment of Ewing sarcoma family of tumors: current status and outlook for the future

1 reference

12 December 2020

Wnt/Frizzled signaling in Ewing sarcoma

1 reference

12 December 2020

Exposure on cell surface and extensive arginine methylation of ewing sarcoma (EWS) protein

1 reference

12 December 2020

Loss of tumorigenicity of Ewing's sarcoma cells expressing antisense RNA to EWS-fusion transcripts

1 reference

12 December 2020

Solution structure of the ets domain of Fli-1 when bound to DNA

1 reference

12 December 2020

Detection and treatment of minimal residual disease in high-risk neuroblastoma.

1 reference

12 December 2020

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

1 reference

12 December 2020

EAT-2 is a novel SH2 domain containing protein that is up regulated by Ewing's sarcoma EWS/FLI1 fusion gene

1 reference

12 December 2020

Interference with the constitutive activation of ERK1 and ERK2 impairs EWS/FLI-1-dependent transformation

1 reference

12 December 2020

The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1.

1 reference

12 December 2020

Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

1 reference

12 December 2020

Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

1 reference

12 December 2020

Vasculogenesis Plays a Role in the Growth of Ewing's Sarcoma in Vivo

1 reference

12 December 2020

Multiple domains mediate transformation by the Ewing's sarcoma EWS/FLI-1 fusion gene

1 reference

12 December 2020

EWS-FLI1, EWS-ERG, and EWS-ETV1 oncoproteins of Ewing tumor family all suppress transcription of transforming growth factor beta type II receptor gene.

1 reference

12 December 2020

Beta-platelet-derived growth factor receptor mediates motility and growth of Ewing's sarcoma cells.

1 reference

12 December 2020

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

1 reference

12 December 2020

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors.

1 reference

12 December 2020

Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol

1 reference

12 December 2020

Identification of Ewing's sarcoma gene product as a glycoprotein using a monoclonal antibody that recognizes an immunodeterminant containing O-linked N-acetylglucosamine moiety

1 reference

12 December 2020

DNA binding domain-independent pathways are involved in EWS/FLI1-mediated oncogenesis.

1 reference

12 December 2020

Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

1 reference

12 December 2020

Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein

1 reference

12 December 2020

Phosphorylation of the EWS IQ domain regulates transcriptional activity of the EWS/ATF1 and EWS/FLI1 fusion proteins

1 reference

12 December 2020

EWS/FLI1 up regulates mE2-C, a cyclin-selective ubiquitin conjugating enzyme involved in cyclin B destruction

1 reference

12 December 2020

Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks

1 reference

12 December 2020

EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

1 reference

12 December 2020

Common musculoskeletal tumors of childhood and adolescence

1 reference

12 December 2020

Dominant negative PDGF-C inhibits growth of Ewing family tumor cell lines

1 reference

12 December 2020

Absence of detectable EWS/FLI1 expression after therapy-induced neural differentiation in Ewing sarcoma.

1 reference

12 December 2020

E1A gene therapy inhibits angiogenesis in a Ewing's sarcoma animal model.

1 reference

12 December 2020

The insulin-like growth factor-I receptor is required for EWS/FLI-1 transformation of fibroblasts

1 reference

12 December 2020

An adenovirus mutant that replicates selectively in p53-deficient human tumor cells

1 reference

12 December 2020

PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors

1 reference

12 December 2020

Cancer-specific viruses and the development of ONYX-015

1 reference

12 December 2020

Induction of cell death by basic fibroblast growth factor in Ewing's sarcoma.

1 reference

12 December 2020

EWS-FLI1 and Ewing's sarcoma: recent molecular data and new insights.

1 reference

12 December 2020

Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

1 reference

12 December 2020

1 reference

12 December 2020

Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with malignant bone tumors

1 reference

12 December 2020

Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

1 reference

12 December 2020

Ewing's sarcoma and peripheral primitive neuroectodermal tumors after their genetic union

1 reference

12 December 2020

Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and may represent an independent predictor of survival in Ewing's sarcoma

1 reference

12 December 2020

Small interfering RNAs expressed from a Pol III promoter suppress the EWS/Fli-1 transcript in an Ewing sarcoma cell line

1 reference

12 December 2020

The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains

1 reference

12 December 2020

Evidence of neural differentiation in a case of post-therapy primitive neuroectodermal tumor/Ewing sarcoma of bone.

1 reference

12 December 2020

c-KIT-expressing Ewing tumour cells are insensitive to imatinib mesylate (STI571).

1 reference

12 December 2020

Experimental evidence for a neural origin of Ewing's sarcoma of bone

1 reference

12 December 2020

The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

1 reference

12 December 2020

An inhibitory carboxyl-terminal domain in Ets-1 and Ets-2 mediates differential binding of ETS family factors to promoter sequences of the mb-1 gene

1 reference

12 December 2020

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

1 reference

12 December 2020

Ewing sarcomas with p53 mutation or p16/p14ARF homozygous deletion: a highly lethal subset associated with poor chemoresponse

1 reference

12 December 2020

Insulin-like growth factor I expression by tumors of neuroectodermal origin with the t(11;22) chromosomal translocation. A potential autocrine growth factor

1 reference

12 December 2020

Quantification of angiogenesis stimulators in children with solid malignancies

1 reference

12 December 2020

10.1007/S11864-005-0025-Y

Identifiers

DOI

1 reference

13 August 2017

1 reference

PubMed ID

16242051