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The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.
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scholarly article
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
title
The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity
(English)
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
main subject
Fragile histidine triad diadenosine triphosphatase
1 reference
stated in
GOA release 2020-03-11
identical protein binding
1 reference
stated in
GOA release 2020-03-11
author
Kai Frederik Albring
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
author name string
Jörg Weiske
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
Otmar Huber
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
language of work or name
English
0 references
publication date
10 December 2007
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
published in
Proceedings of the National Academy of Sciences of the United States of America
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
volume
104
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
issue
51
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
page(s)
20344-20349
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
cites work
Fragile histidine triad-mediated tumor suppression of lung cancer by targeting multiple components of the Ras/Rho GTPase molecular switch
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Counting colonies of clonogenic assays by using densitometric software
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
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30 September 2017
FHIT-proteasome degradation caused by mitogenic stimulation of the EGF receptor family in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The histidine triad protein Hint1 triggers apoptosis independent of its enzymatic activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Fhit protein inhibits cell growth by attenuating the signaling mediated by nuclear factor-kappaB in colon cancer cell lines
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Transcription under the control of nuclear Arm/beta-catenin.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The histidine triad protein Hint1 interacts with Pontin and Reptin and inhibits TCF-beta-catenin-mediated transcription
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
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30 September 2017
Differential roles for the coactivators CBP and p300 on TCF/beta-catenin-mediated survivin gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Fhit is a physiological target of the protein kinase Src
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Alteration of the fragile histidine triad gene early in carcinogenesis: an update.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Caught up in a Wnt storm: Wnt signaling in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Cancer and the FRA3B/FHIT fragile locus: it's a HIT
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
FHIT: from gene discovery to cancer treatment and prevention
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Regulation of epithelial cell migration and tumor formation by beta-catenin signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The fate of desmosomal proteins in apoptotic cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Curbing the nuclear activities of beta-catenin. Control over Wnt target gene expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The histidine triad superfamily of nucleotide-binding proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Nuclear endpoint of Wnt signaling: neoplastic transformation induced by transactivating lymphoid-enhancing factor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Replacement of Fhit in cancer cells suppresses tumorigenicity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Structure-based analysis of catalysis and substrate definition in the HIT protein family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Nuclear localization of beta-catenin by interaction with transcription factor LEF-1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
30 September 2017
Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
22 September 2018
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
22 September 2018
Survivin and molecular pathogenesis of colorectal cancer.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
22 September 2018
Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
22 September 2018
FRA3B and other common fragile sites: the weakest links
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2154433
retrieved
22 September 2018
Radiosensitization by 2-benzoyl-3-phenyl-6,7-dichloroquinoxaline 1,4-dioxide under oxia and hypoxia in human colon cancer cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1073%2FPNAS.0703664105
retrieved
21 January 2018
Identifiers
DOI
10.1073/PNAS.0703664105
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
ADS bibcode
2007PNAS..10420344W
0 references
PMCID
2154433
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
PubMed ID
18077326
1 reference
stated in
Europe PubMed Central
PMCID
2154433
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18077326%20AND%20SRC:MED&resulttype=core&format=json
retrieved
29 December 2019
ResearchGate publication ID
5771899
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